| agost del 202517 d’ag. | Ligue 1 | Stade Brestois 29 3–3 LilleRegular Season - 1 | E |
| 24 d’ag. | Ligue 1 | Lille 1–0 MonacoRegular Season - 2 | V |
| 30 d’ag. | Ligue 1 | Lorient 1–7 LilleRegular Season - 3 | V |
| setembre del 202514 de set. | Ligue 1 | Lille 2–1 ToulouseRegular Season - 4 | V |
| 20 de set. | Ligue 1 | Lens 3–0 LilleRegular Season - 5 | D |
| 25 de set. | Europa League | Lille 2–1 BrannLeague Stage - 1 | V |
| 28 de set. | Ligue 1 | Lille 0–1 LyonRegular Season - 6 | D |
| octubre del 202502 d’oct. | Europa League | AS Roma 0–1 LilleLeague Stage - 2 | V |
| 05 d’oct. | Ligue 1 | Lille 1–1 Paris Saint GermainRegular Season - 7 | E |
| 19 d’oct. | Ligue 1 | Nantes 0–2 LilleRegular Season - 8 | V |
| 23 d’oct. | Europa League | Lille 3–4 PAOKLeague Stage - 3 | D |
| 26 d’oct. | Ligue 1 | Lille 6–1 MetzRegular Season - 9 | V |
| 29 d’oct. | Ligue 1 | Nice 2–0 LilleRegular Season - 10 | D |
| novembre del 202502 de nov. | Ligue 1 | Lille 1–0 AngersRegular Season - 11 | V |
| 06 de nov. | Europa League | FK Crvena Zvezda 1–0 LilleLeague Stage - 4 | D |
| 09 de nov. | Ligue 1 | Strasbourg 2–0 LilleRegular Season - 12 | D |
| 23 de nov. | Ligue 1 | Lille 4–2 Paris FCRegular Season - 13 | V |
| 27 de nov. | Europa League | Lille 4–0 Dinamo ZagrebLeague Stage - 5 | V |
| 30 de nov. | Ligue 1 | Le Havre 0–1 LilleRegular Season - 14 | V |
| desembre del 202505 de des. | Ligue 1 | Lille 1–0 MarseilleRegular Season - 15 | V |
| 11 de des. | Europa League | BSC Young Boys 1–0 LilleLeague Stage - 6 | D |
| 14 de des. | Ligue 1 | Auxerre 3–4 LilleRegular Season - 16 | V |
| gener del 202603 de gen. | Ligue 1 | Lille 0–2 RennesRegular Season - 17 | D |
| 16 de gen. | Ligue 1 | Paris Saint Germain 3–0 LilleRegular Season - 18 | D |
| 22 de gen. | Europa League | Celta Vigo 2–1 LilleLeague Stage - 7 | D |
| 25 de gen. | Ligue 1 | Lille 1–4 StrasbourgRegular Season - 19 | D |
| 29 de gen. | Europa League | Lille 1–0 SC FreiburgLeague Stage - 8 | V |
| febrer del 202601 de febr. | Ligue 1 | Lyon 1–0 LilleRegular Season - 20 | D |
| 06 de febr. | Ligue 1 | Metz 0–0 LilleRegular Season - 21 | E |
| 14 de febr. | Ligue 1 | Lille 1–1 Stade Brestois 29Regular Season - 22 | E |
| 19 de febr. | Europa League | Lille 0–1 FK Crvena ZvezdaRound of 32 | D |
| 22 de febr. | Ligue 1 | Angers 0–1 LilleRegular Season - 23 | V |
| 26 de febr. | Europa League | FK Crvena Zvezda 0–1 LilleRound of 32 | V |
| març del 202601 de març | Ligue 1 | Lille 1–0 NantesRegular Season - 24 | V |
| 08 de març | Ligue 1 | Lille 1–1 LorientRegular Season - 25 | E |
| 12 de març | Europa League | Lille 0–1 Aston VillaRound of 16 | D |
| 15 de març | Ligue 1 | Rennes 1–2 LilleRegular Season - 26 | V |
| 19 de març | Europa League | Aston Villa 2–0 LilleRound of 16 | D |
| 22 de març | Ligue 1 | Marseille 1–2 LilleRegular Season - 27 | V |
| abril del 202604 d’abr. | Ligue 1 | Lille 3–0 LensRegular Season - 28 | V |
| 12 d’abr. | Ligue 1 | Toulouse 0–4 LilleRegular Season - 29 | V |
| 18 d’abr. | Ligue 1 | Lille 0–0 NiceRegular Season - 30 | E |
| 26 d’abr. | Ligue 1 | Paris FC 0–1 LilleRegular Season - 31 | V |
| maig del 202603 de maig | Ligue 1 | Lille 1–1 Le HavreRegular Season - 32 | E |
| 10 de maig | Ligue 1 | Monaco 0–1 LilleRegular Season - 33 | V |
| 17 de maig | Ligue 1 | Lille 0–2 AuxerreRegular Season - 34 | D |