| August 2025Aug 24 |  Serie A | Como 2–0 LazioRegular Season - 1 | W |
| Aug 30 | Serie A | Bologna 1–0ComoRegular Season - 2 | L |
| September 2025Sep 15 | Serie A | Como1–1 GenoaRegular Season - 3 | D |
| Sep 21 | Serie A | Fiorentina 1–2ComoRegular Season - 4 | W |
| Sep 27 | Serie A | Como1–1 CremoneseRegular Season - 5 | D |
| October 2025Oct 04 | Serie A | Atalanta 1–1ComoRegular Season - 6 | D |
| Oct 19 | Serie A | Como2–0 JuventusRegular Season - 7 | W |
| Oct 25 | Serie A | Parma 0–0ComoRegular Season - 8 | D |
| Oct 29 | Serie A | Como3–1 Hellas VeronaRegular Season - 9 | W |
| November 2025Nov 01 | Serie A | Napoli 0–0ComoRegular Season - 10 | D |
| Nov 08 | Serie A | Como0–0 CagliariRegular Season - 11 | D |
| Nov 24 | Serie A | Torino 1–5ComoRegular Season - 12 | W |
| Nov 28 | Serie A | Como2–0 SassuoloRegular Season - 13 | W |
| December 2025Dec 06 | Serie A | Inter 4–0ComoRegular Season - 14 | L |
| Dec 15 | Serie A | AS Roma 1–0ComoRegular Season - 15 | L |
| Dec 27 | Serie A | Lecce 0–3ComoRegular Season - 17 | W |
| January 2026Jan 03 | Serie A | Como1–0 UdineseRegular Season - 18 | W |
| Jan 06 | Serie A | Pisa 0–3ComoRegular Season - 19 | W |
| Jan 10 | Serie A | Como1–1BolognaRegular Season - 20 | D |
| Jan 15 | Serie A | Como1–3 AC MilanRegular Season - 16 | L |
| Jan 19 | Serie A | Lazio0–3ComoRegular Season - 21 | W |
| Jan 24 | Serie A | Como6–0TorinoRegular Season - 22 | W |
| February 2026Feb 01 | Serie A | Como0–0AtalantaRegular Season - 23 | D |
| Feb 14 | Serie A | Como1–2FiorentinaRegular Season - 25 | L |
| Feb 18 | Serie A | AC Milan1–1ComoRegular Season - 24 | D |
| Feb 21 | Serie A | Juventus0–2ComoRegular Season - 26 | W |
| Feb 28 | Serie A | Como3–1LecceRegular Season - 27 | W |
| March 2026Mar 07 | Serie A | Cagliari1–2ComoRegular Season - 28 | W |
| Mar 15 | Serie A | Como2–1AS RomaRegular Season - 29 | W |
| Mar 22 | Serie A | Como5–0PisaRegular Season - 30 | W |
| April 2026Apr 06 | Serie A | Udinese0–0ComoRegular Season - 31 | D |
| Apr 12 | Serie A | Como3–4InterRegular Season - 32 | L |
| Apr 17 | Serie A | Sassuolo2–1ComoRegular Season - 33 | L |
| Apr 26 | Serie A | Genoa0–2ComoRegular Season - 34 | W |
| May 2026May 02 | Serie A | Como0–0NapoliRegular Season - 35 | D |
| May 10 | Serie A | Hellas Verona0–1ComoRegular Season - 36 | W |
| May 17 | Serie A | Como1–0ParmaRegular Season - 37 | W |
| May 24 | Serie A | Cremonese1–4ComoRegular Season - 38 | W |
