| August 2025Aug 17 |  Ligue 1 | Stade Brestois 29 3–3 LilleRegular Season - 1 | D |
| Aug 24 | Ligue 1 | Lille1–0 MonacoRegular Season - 2 | W |
| Aug 30 | Ligue 1 | Lorient 1–7LilleRegular Season - 3 | W |
| September 2025Sep 14 | Ligue 1 | Lille2–1 ToulouseRegular Season - 4 | W |
| Sep 20 | Ligue 1 | Lens 3–0LilleRegular Season - 5 | L |
| Sep 25 |  Europa League | Lille2–1 BrannLeague Stage - 1 | W |
| Sep 28 | Ligue 1 | Lille0–1 LyonRegular Season - 6 | L |
| October 2025Oct 02 | Europa League | AS Roma 0–1LilleLeague Stage - 2 | W |
| Oct 05 | Ligue 1 | Lille1–1 Paris Saint GermainRegular Season - 7 | D |
| Oct 19 | Ligue 1 | Nantes 0–2LilleRegular Season - 8 | W |
| Oct 23 | Europa League | Lille3–4 PAOKLeague Stage - 3 | L |
| Oct 26 | Ligue 1 | Lille6–1 MetzRegular Season - 9 | W |
| Oct 29 | Ligue 1 | Nice 2–0LilleRegular Season - 10 | L |
| November 2025Nov 02 | Ligue 1 | Lille1–0 AngersRegular Season - 11 | W |
| Nov 06 | Europa League | FK Crvena Zvezda 1–0LilleLeague Stage - 4 | L |
| Nov 09 | Ligue 1 | Strasbourg 2–0LilleRegular Season - 12 | L |
| Nov 23 | Ligue 1 | Lille4–2 Paris FCRegular Season - 13 | W |
| Nov 27 | Europa League | Lille4–0 Dinamo ZagrebLeague Stage - 5 | W |
| Nov 30 | Ligue 1 | Le Havre 0–1LilleRegular Season - 14 | W |
| December 2025Dec 05 | Ligue 1 | Lille1–0 MarseilleRegular Season - 15 | W |
| Dec 11 | Europa League | BSC Young Boys 1–0LilleLeague Stage - 6 | L |
| Dec 14 | Ligue 1 | Auxerre 3–4LilleRegular Season - 16 | W |
| January 2026Jan 03 | Ligue 1 | Lille0–2 RennesRegular Season - 17 | L |
| Jan 16 | Ligue 1 | Paris Saint Germain3–0LilleRegular Season - 18 | L |
| Jan 22 | Europa League | Celta Vigo 2–1LilleLeague Stage - 7 | L |
| Jan 25 | Ligue 1 | Lille1–4StrasbourgRegular Season - 19 | L |
| Jan 29 | Europa League | Lille1–0 SC FreiburgLeague Stage - 8 | W |
| February 2026Feb 01 | Ligue 1 | Lyon1–0LilleRegular Season - 20 | L |
| Feb 06 | Ligue 1 | Metz0–0LilleRegular Season - 21 | D |
| Feb 14 | Ligue 1 | Lille1–1Stade Brestois 29Regular Season - 22 | D |
| Feb 19 | Europa League | Lille0–1FK Crvena ZvezdaRound of 32 | L |
| Feb 22 | Ligue 1 | Angers0–1LilleRegular Season - 23 | W |
| Feb 26 | Europa League | FK Crvena Zvezda0–1LilleRound of 32 | W |
| March 2026Mar 01 | Ligue 1 | Lille1–0NantesRegular Season - 24 | W |
| Mar 08 | Ligue 1 | Lille1–1LorientRegular Season - 25 | D |
| Mar 12 | Europa League | Lille0–1 Aston VillaRound of 16 | L |
| Mar 15 | Ligue 1 | Rennes1–2LilleRegular Season - 26 | W |
| Mar 19 | Europa League | Aston Villa2–0LilleRound of 16 | L |
| Mar 22 | Ligue 1 | Marseille1–2LilleRegular Season - 27 | W |
| April 2026Apr 04 | Ligue 1 | Lille3–0LensRegular Season - 28 | W |
| Apr 12 | Ligue 1 | Toulouse0–4LilleRegular Season - 29 | W |
| Apr 18 | Ligue 1 | Lille0–0NiceRegular Season - 30 | D |
| Apr 26 | Ligue 1 | Paris FC0–1LilleRegular Season - 31 | W |
| May 2026May 03 | Ligue 1 | Lille1–1Le HavreRegular Season - 32 | D |
| May 10 | Ligue 1 | Monaco0–1LilleRegular Season - 33 | W |
| May 17 | Ligue 1 | Lille0–2AuxerreRegular Season - 34 | L |
