| August 2025Aug 23 |  Serie A | Sassuolo 0–2 NapoliRegular Season - 1 | W |
| Aug 30 | Serie A | Napoli1–0 CagliariRegular Season - 2 | W |
| September 2025Sep 13 | Serie A | Fiorentina 1–3NapoliRegular Season - 3 | W |
| Sep 18 |  Champions League | Manchester City 2–0NapoliLeague Stage - 1 | L |
| Sep 22 | Serie A | Napoli3–2 PisaRegular Season - 4 | W |
| Sep 28 | Serie A | AC Milan 2–1NapoliRegular Season - 5 | L |
| October 2025Oct 01 | Champions League | Napoli2–1 Sporting CPLeague Stage - 2 | W |
| Oct 05 | Serie A | Napoli2–1 GenoaRegular Season - 6 | W |
| Oct 18 | Serie A | Torino 1–0NapoliRegular Season - 7 | L |
| Oct 21 | Champions League | PSV Eindhoven 6–2NapoliLeague Stage - 3 | L |
| Oct 25 | Serie A | Napoli3–1 InterRegular Season - 8 | W |
| Oct 28 | Serie A | Lecce 0–1NapoliRegular Season - 9 | W |
| November 2025Nov 01 | Serie A | Napoli0–0 ComoRegular Season - 10 | D |
| Nov 04 | Champions League | Napoli0–0 Eintracht FrankfurtLeague Stage - 4 | D |
| Nov 09 | Serie A | Bologna 2–0NapoliRegular Season - 11 | L |
| Nov 22 | Serie A | Napoli3–1 AtalantaRegular Season - 12 | W |
| Nov 25 | Champions League | Napoli2–0 QarabagLeague Stage - 5 | W |
| Nov 30 | Serie A | AS Roma 0–1NapoliRegular Season - 13 | W |
| December 2025Dec 07 | Serie A | Napoli2–1 JuventusRegular Season - 14 | W |
| Dec 10 | Champions League | Benfica 2–0NapoliLeague Stage - 6 | L |
| Dec 14 | Serie A | Udinese 1–0NapoliRegular Season - 15 | L |
| Dec 28 | Serie A | Cremonese 0–2NapoliRegular Season - 17 | W |
| January 2026Jan 04 | Serie A | Lazio 0–2NapoliRegular Season - 18 | W |
| Jan 07 | Serie A | Napoli2–2 Hellas VeronaRegular Season - 19 | D |
| Jan 11 | Serie A | Inter2–2NapoliRegular Season - 20 | D |
| Jan 14 | Serie A | Napoli0–0 ParmaRegular Season - 16 | D |
| Jan 17 | Serie A | Napoli1–0SassuoloRegular Season - 21 | W |
| Jan 20 | Champions League | FC Copenhagen 1–1NapoliLeague Stage - 7 | D |
| Jan 25 | Serie A | Juventus3–0NapoliRegular Season - 22 | L |
| Jan 28 | Champions League | Napoli2–3 ChelseaLeague Stage - 8 | L |
| Jan 31 | Serie A | Napoli2–1FiorentinaRegular Season - 23 | W |
| February 2026Feb 07 | Serie A | Genoa2–3NapoliRegular Season - 24 | W |
| Feb 15 | Serie A | Napoli2–2AS RomaRegular Season - 25 | D |
| Feb 22 | Serie A | Atalanta2–1NapoliRegular Season - 26 | L |
| Feb 28 | Serie A | Hellas Verona1–2NapoliRegular Season - 27 | W |
| March 2026Mar 06 | Serie A | Napoli2–1TorinoRegular Season - 28 | W |
| Mar 14 | Serie A | Napoli2–1LecceRegular Season - 29 | W |
| Mar 20 | Serie A | Cagliari0–1NapoliRegular Season - 30 | W |
| April 2026Apr 06 | Serie A | Napoli1–0AC MilanRegular Season - 31 | W |
| Apr 12 | Serie A | Parma1–1NapoliRegular Season - 32 | D |
| Apr 18 | Serie A | Napoli0–2LazioRegular Season - 33 | L |
| Apr 24 | Serie A | Napoli4–0CremoneseRegular Season - 34 | W |
| May 2026May 02 | Serie A | Como0–0NapoliRegular Season - 35 | D |
| May 11 | Serie A | Napoli2–3BolognaRegular Season - 36 | L |
| May 17 | Serie A | Pisa0–3NapoliRegular Season - 37 | W |
| May 24 | Serie A | Napoli1–0UdineseRegular Season - 38 | W |
