| August 2025Aug 23 |  Serie A | Sassuolo 0–2 NapoliRegular Season - 1 | L |
| Aug 29 | Serie A | Cremonese 3–2SassuoloRegular Season - 2 | L |
| September 2025Sep 14 | Serie A | Sassuolo1–0 LazioRegular Season - 3 | W |
| Sep 21 | Serie A | Inter 2–1SassuoloRegular Season - 4 | L |
| Sep 28 | Serie A | Sassuolo3–1 UdineseRegular Season - 5 | W |
| October 2025Oct 03 | Serie A | Hellas Verona 0–1SassuoloRegular Season - 6 | W |
| Oct 18 | Serie A | Lecce 0–0SassuoloRegular Season - 7 | D |
| Oct 26 | Serie A | Sassuolo0–1 AS RomaRegular Season - 8 | L |
| Oct 30 | Serie A | Cagliari 1–2SassuoloRegular Season - 9 | W |
| November 2025Nov 03 | Serie A | Sassuolo1–2 GenoaRegular Season - 10 | L |
| Nov 09 | Serie A | Atalanta 0–3SassuoloRegular Season - 11 | W |
| Nov 24 | Serie A | Sassuolo2–2 PisaRegular Season - 12 | D |
| Nov 28 | Serie A | Como 2–0SassuoloRegular Season - 13 | L |
| December 2025Dec 06 | Serie A | Sassuolo3–1 FiorentinaRegular Season - 14 | W |
| Dec 14 | Serie A | AC Milan 2–2SassuoloRegular Season - 15 | D |
| Dec 21 | Serie A | Sassuolo0–1 TorinoRegular Season - 16 | L |
| Dec 28 | Serie A | Bologna 1–1SassuoloRegular Season - 17 | D |
| January 2026Jan 03 | Serie A | Sassuolo1–1 ParmaRegular Season - 18 | D |
| Jan 06 | Serie A | Sassuolo0–3 JuventusRegular Season - 19 | L |
| Jan 10 | Serie A | AS Roma2–0SassuoloRegular Season - 20 | L |
| Jan 17 | Serie A | Napoli1–0SassuoloRegular Season - 21 | L |
| Jan 25 | Serie A | Sassuolo1–0CremoneseRegular Season - 22 | W |
| Jan 31 | Serie A | Pisa1–3SassuoloRegular Season - 23 | W |
| February 2026Feb 08 | Serie A | Sassuolo0–5InterRegular Season - 24 | L |
| Feb 15 | Serie A | Udinese1–2SassuoloRegular Season - 25 | W |
| Feb 20 | Serie A | Sassuolo3–0Hellas VeronaRegular Season - 26 | W |
| March 2026Mar 01 | Serie A | Sassuolo2–1AtalantaRegular Season - 27 | W |
| Mar 09 | Serie A | Lazio2–1SassuoloRegular Season - 28 | L |
| Mar 15 | Serie A | Sassuolo0–1BolognaRegular Season - 29 | L |
| Mar 21 | Serie A | Juventus1–1SassuoloRegular Season - 30 | D |
| April 2026Apr 04 | Serie A | Sassuolo2–1CagliariRegular Season - 31 | W |
| Apr 12 | Serie A | Genoa2–1SassuoloRegular Season - 32 | L |
| Apr 17 | Serie A | Sassuolo2–1ComoRegular Season - 33 | W |
| Apr 26 | Serie A | Fiorentina0–0SassuoloRegular Season - 34 | D |
| May 2026May 03 | Serie A | Sassuolo2–0AC MilanRegular Season - 35 | W |
| May 08 | Serie A | Torino2–1SassuoloRegular Season - 36 | L |
| May 17 | Serie A | Sassuolo2–3LecceRegular Season - 37 | L |
| May 24 | Serie A | Parma1–0SassuoloRegular Season - 38 | L |
