| agost del 202524 d’ag. |  Bundesliga | FSV Mainz 05 0–1 1. FC KölnRegular Season - 1 | V |
| 31 d’ag. | Bundesliga | 1. FC Köln4–1 SC FreiburgRegular Season - 2 | V |
| setembre del 202513 de set. | Bundesliga | VfL Wolfsburg 3–31. FC KölnRegular Season - 3 | E |
| 20 de set. | Bundesliga | RB Leipzig 3–11. FC KölnRegular Season - 4 | D |
| 28 de set. | Bundesliga | 1. FC Köln1–2 VfB StuttgartRegular Season - 5 | D |
| octubre del 202503 d’oct. | Bundesliga | 1899 Hoffenheim 0–11. FC KölnRegular Season - 6 | V |
| 18 d’oct. | Bundesliga | 1. FC Köln1–1 FC AugsburgRegular Season - 7 | E |
| 25 d’oct. | Bundesliga | Borussia Dortmund 1–01. FC KölnRegular Season - 8 | D |
| novembre del 202502 de nov. | Bundesliga | 1. FC Köln4–1 Hamburger SVRegular Season - 9 | V |
| 08 de nov. | Bundesliga | Borussia Mönchengladbach 3–11. FC KölnRegular Season - 10 | D |
| 22 de nov. | Bundesliga | 1. FC Köln3–4 Eintracht FrankfurtRegular Season - 11 | D |
| 29 de nov. | Bundesliga | Werder Bremen 1–11. FC KölnRegular Season - 12 | E |
| desembre del 202506 de des. | Bundesliga | 1. FC Köln1–1 FC St. PauliRegular Season - 13 | E |
| 13 de des. | Bundesliga | Bayer Leverkusen 2–01. FC KölnRegular Season - 14 | D |
| 20 de des. | Bundesliga | 1. FC Köln0–1 Union BerlinRegular Season - 15 | D |
| gener del 202610 de gen. | Bundesliga | 1. FC Heidenheim 2–21. FC KölnRegular Season - 16 | E |
| 14 de gen. | Bundesliga | 1. FC Köln1–3 Bayern MünchenRegular Season - 17 | D |
| 17 de gen. | Bundesliga | 1. FC Köln2–1FSV Mainz 05Regular Season - 18 | V |
| 25 de gen. | Bundesliga | SC Freiburg2–11. FC KölnRegular Season - 19 | D |
| 30 de gen. | Bundesliga | 1. FC Köln1–0VfL WolfsburgRegular Season - 20 | V |
| febrer del 202608 de febr. | Bundesliga | 1. FC Köln1–2RB LeipzigRegular Season - 21 | D |
| 14 de febr. | Bundesliga | VfB Stuttgart3–11. FC KölnRegular Season - 22 | D |
| 21 de febr. | Bundesliga | 1. FC Köln2–21899 HoffenheimRegular Season - 23 | E |
| 27 de febr. | Bundesliga | FC Augsburg2–01. FC KölnRegular Season - 24 | D |
| març del 202607 de març | Bundesliga | 1. FC Köln1–2Borussia DortmundRegular Season - 25 | D |
| 14 de març | Bundesliga | Hamburger SV1–11. FC KölnRegular Season - 26 | E |
| 21 de març | Bundesliga | 1. FC Köln3–3Borussia MönchengladbachRegular Season - 27 | E |
| abril del 202605 d’abr. | Bundesliga | Eintracht Frankfurt2–21. FC KölnRegular Season - 28 | E |
| 12 d’abr. | Bundesliga | 1. FC Köln3–1Werder BremenRegular Season - 29 | V |
| 17 d’abr. | Bundesliga | FC St. Pauli1–11. FC KölnRegular Season - 30 | E |
| 25 d’abr. | Bundesliga | 1. FC Köln1–2Bayer LeverkusenRegular Season - 31 | D |
| maig del 202602 de maig | Bundesliga | Union Berlin2–21. FC KölnRegular Season - 32 | E |
| 10 de maig | Bundesliga | 1. FC Köln1–31. FC HeidenheimRegular Season - 33 | D |
| 16 de maig | Bundesliga | Bayern München5–11. FC KölnRegular Season - 34 | D |
