| agost del 202424 d’ag. |  Bundesliga | 1899 Hoffenheim 3–2 Holstein KielRegular Season - 1 | V |
| 31 d’ag. | Bundesliga | Eintracht Frankfurt 3–11899 HoffenheimRegular Season - 2 | D |
| setembre del 202414 de set. | Bundesliga | 1899 Hoffenheim1–4 Bayer LeverkusenRegular Season - 3 | D |
| 21 de set. | Bundesliga | Union Berlin 2–11899 HoffenheimRegular Season - 4 | D |
| 25 de set. |  Europa League | FC Midtjylland 1–11899 HoffenheimLeague Stage - 1 | E |
| 29 de set. | Bundesliga | 1899 Hoffenheim3–4 Werder BremenRegular Season - 5 | D |
| octubre del 202403 d’oct. | Europa League | 1899 Hoffenheim2–0 Dynamo KyivLeague Stage - 2 | V |
| 06 d’oct. | Bundesliga | VfB Stuttgart 1–11899 HoffenheimRegular Season - 6 | E |
| 19 d’oct. | Bundesliga | 1899 Hoffenheim3–1 VfL BochumRegular Season - 7 | V |
| 24 d’oct. | Europa League | FC Porto 2–01899 HoffenheimLeague Stage - 3 | D |
| 27 d’oct. | Bundesliga | 1. FC Heidenheim 0–01899 HoffenheimRegular Season - 8 | E |
| novembre del 202402 de nov. | Bundesliga | 1899 Hoffenheim0–2 FC St. PauliRegular Season - 9 | D |
| 07 de nov. | Europa League | 1899 Hoffenheim2–2 LyonLeague Stage - 4 | E |
| 10 de nov. | Bundesliga | FC Augsburg 0–01899 HoffenheimRegular Season - 10 | E |
| 23 de nov. | Bundesliga | 1899 Hoffenheim4–3 RB LeipzigRegular Season - 11 | V |
| 28 de nov. | Europa League | SC Braga 3–01899 HoffenheimLeague Stage - 5 | D |
| desembre del 202401 de des. | Bundesliga | FSV Mainz 05 2–01899 HoffenheimRegular Season - 12 | D |
| 08 de des. | Bundesliga | 1899 Hoffenheim1–1 SC FreiburgRegular Season - 13 | E |
| 12 de des. | Europa League | 1899 Hoffenheim0–0 FCSBLeague Stage - 6 | E |
| 15 de des. | Bundesliga | Borussia Dortmund 1–11899 HoffenheimRegular Season - 14 | E |
| 21 de des. | Bundesliga | 1899 Hoffenheim1–2 Borussia MönchengladbachRegular Season - 15 | D |
| gener del 202511 de gen. | Bundesliga | 1899 Hoffenheim0–1 VfL WolfsburgRegular Season - 16 | D |
| 15 de gen. | Bundesliga | Bayern München 5–01899 HoffenheimRegular Season - 17 | D |
| 18 de gen. | Bundesliga | Holstein Kiel1–31899 HoffenheimRegular Season - 18 | V |
| 23 de gen. | Europa League | 1899 Hoffenheim2–3 TottenhamLeague Stage - 7 | D |
| 26 de gen. | Bundesliga | 1899 Hoffenheim2–2Eintracht FrankfurtRegular Season - 19 | E |
| 30 de gen. | Europa League | Anderlecht 3–41899 HoffenheimLeague Stage - 8 | V |
| febrer del 202502 de febr. | Bundesliga | Bayer Leverkusen3–11899 HoffenheimRegular Season - 20 | D |
| 08 de febr. | Bundesliga | 1899 Hoffenheim0–4Union BerlinRegular Season - 21 | D |
| 16 de febr. | Bundesliga | Werder Bremen1–31899 HoffenheimRegular Season - 22 | V |
| 23 de febr. | Bundesliga | 1899 Hoffenheim1–1VfB StuttgartRegular Season - 23 | E |
| març del 202501 de març | Bundesliga | VfL Bochum0–11899 HoffenheimRegular Season - 24 | V |
| 09 de març | Bundesliga | 1899 Hoffenheim1–11. FC HeidenheimRegular Season - 25 | E |
| 14 de març | Bundesliga | FC St. Pauli1–01899 HoffenheimRegular Season - 26 | D |
| 29 de març | Bundesliga | 1899 Hoffenheim1–1FC AugsburgRegular Season - 27 | E |
| abril del 202505 d’abr. | Bundesliga | RB Leipzig3–11899 HoffenheimRegular Season - 28 | D |
| 12 d’abr. | Bundesliga | 1899 Hoffenheim2–0FSV Mainz 05Regular Season - 29 | V |
| 19 d’abr. | Bundesliga | SC Freiburg3–21899 HoffenheimRegular Season - 30 | D |
| 26 d’abr. | Bundesliga | 1899 Hoffenheim2–3Borussia DortmundRegular Season - 31 | D |
| maig del 202503 de maig | Bundesliga | Borussia Mönchengladbach4–41899 HoffenheimRegular Season - 32 | E |
| 09 de maig | Bundesliga | VfL Wolfsburg2–21899 HoffenheimRegular Season - 33 | E |
| 17 de maig | Bundesliga | 1899 Hoffenheim0–4Bayern MünchenRegular Season - 34 | D |
