| juliol del 202526 de jul. |  Jupiler Pro League | Zulte Waregem 1–1 KV MechelenRegular Season - 1 | E |
| agost del 202501 d’ag. | Jupiler Pro League | KV Mechelen2–1 Club Brugge KVRegular Season - 2 | V |
| 09 d’ag. | Jupiler Pro League | KVC Westerlo 0–1KV MechelenRegular Season - 3 | V |
| 16 d’ag. | Jupiler Pro League | KV Mechelen1–1 GentRegular Season - 4 | E |
| 24 d’ag. | Jupiler Pro League | Antwerp 2–1KV MechelenRegular Season - 5 | D |
| 30 d’ag. | Jupiler Pro League | KV Mechelen3–2 RAAL La LouvièreRegular Season - 6 | V |
| setembre del 202512 de set. | Jupiler Pro League | Standard Liege 1–1KV MechelenRegular Season - 7 | E |
| 21 de set. | Jupiler Pro League | KV Mechelen0–0 Cercle BruggeRegular Season - 8 | E |
| 28 de set. | Jupiler Pro League | Charleroi 0–2KV MechelenRegular Season - 9 | V |
| octubre del 202504 d’oct. | Jupiler Pro League | KV Mechelen1–3 St. TruidenRegular Season - 10 | D |
| 19 d’oct. | Jupiler Pro League | Dender 1–3KV MechelenRegular Season - 11 | V |
| 25 d’oct. | Jupiler Pro League | KV Mechelen1–1 OH LeuvenRegular Season - 12 | E |
| novembre del 202501 de nov. | Jupiler Pro League | Anderlecht 3–1KV MechelenRegular Season - 13 | D |
| 09 de nov. | Jupiler Pro League | KV Mechelen1–1 Union St. GilloiseRegular Season - 14 | E |
| 23 de nov. | Jupiler Pro League | Genk 0–1KV MechelenRegular Season - 15 | V |
| 28 de nov. | Jupiler Pro League | KV Mechelen0–1Standard LiegeRegular Season - 16 | D |
| desembre del 202507 de des. | Jupiler Pro League | KV Mechelen1–0CharleroiRegular Season - 17 | V |
| 13 de des. | Jupiler Pro League | Cercle Brugge2–3KV MechelenRegular Season - 18 | V |
| 21 de des. | Jupiler Pro League | St. Truiden1–0KV MechelenRegular Season - 19 | D |
| 27 de des. | Jupiler Pro League | KV Mechelen1–1DenderRegular Season - 20 | E |
| gener del 202617 de gen. | Jupiler Pro League | Union St. Gilloise1–0KV MechelenRegular Season - 21 | D |
| 25 de gen. | Jupiler Pro League | KV Mechelen1–1KVC WesterloRegular Season - 22 | E |
| febrer del 202601 de febr. | Jupiler Pro League | OH Leuven2–2KV MechelenRegular Season - 23 | E |
| 08 de febr. | Jupiler Pro League | KV Mechelen2–0AntwerpRegular Season - 24 | V |
| 13 de febr. | Jupiler Pro League | KV Mechelen2–3GenkRegular Season - 25 | D |
| 22 de febr. | Jupiler Pro League | RAAL La Louvière0–2KV MechelenRegular Season - 26 | V |
| 28 de febr. | Jupiler Pro League | KV Mechelen2–1Zulte WaregemRegular Season - 27 | V |
| març del 202608 de març | Jupiler Pro League | Gent3–1KV MechelenRegular Season - 28 | D |
| 15 de març | Jupiler Pro League | KV Mechelen1–0AnderlechtRegular Season - 29 | V |
| 22 de març | Jupiler Pro League | Club Brugge KV4–1KV MechelenRegular Season - 30 | D |
| abril del 202606 d’abr. | Jupiler Pro League | Gent1–1KV MechelenChampionship Group - 31 | E |
| 12 d’abr. | Jupiler Pro League | KV Mechelen0–1Union St. GilloiseChampionship Group - 32 | D |
| 18 d’abr. | Jupiler Pro League | KV Mechelen1–2AnderlechtChampionship Group - 33 | D |
| 22 d’abr. | Jupiler Pro League | Club Brugge KV6–1KV MechelenChampionship Group - 34 | D |
| 26 d’abr. | Jupiler Pro League | KV Mechelen1–4St. TruidenChampionship Group - 35 | D |
| maig del 202603 de maig | Jupiler Pro League | KV Mechelen1–0GentChampionship Group - 36 | V |
| 10 de maig | Jupiler Pro League | Union St. Gilloise3–0KV MechelenChampionship Group - 37 | D |
| 17 de maig | Jupiler Pro League | Anderlecht2–2KV MechelenChampionship Group - 38 | E |
| 21 de maig | Jupiler Pro League | KV Mechelen2–2Club Brugge KVChampionship Group - 39 | E |
| 24 de maig | Jupiler Pro League | St. Truiden3–0KV MechelenChampionship Group - 40 | D |
