| agost del 202516 d’ag. |  Ligue 1 | Lens 0–1 LyonRegular Season - 1 | V |
| 23 d’ag. | Ligue 1 | Lyon3–0 MetzRegular Season - 2 | V |
| 31 d’ag. | Ligue 1 | Lyon1–0 MarseilleRegular Season - 3 | V |
| setembre del 202514 de set. | Ligue 1 | Rennes 3–1LyonRegular Season - 4 | D |
| 19 de set. | Ligue 1 | Lyon1–0 AngersRegular Season - 5 | V |
| 25 de set. |  Europa League | Utrecht 0–1LyonLeague Stage - 1 | V |
| 28 de set. | Ligue 1 | Lille 0–1LyonRegular Season - 6 | V |
| octubre del 202502 d’oct. | Europa League | Lyon2–0 Red Bull SalzburgLeague Stage - 2 | V |
| 05 d’oct. | Ligue 1 | Lyon1–2 ToulouseRegular Season - 7 | D |
| 18 d’oct. | Ligue 1 | Nice 3–2LyonRegular Season - 8 | D |
| 23 d’oct. | Europa League | Lyon2–0 FC Basel 1893League Stage - 3 | V |
| 26 d’oct. | Ligue 1 | Lyon2–1 StrasbourgRegular Season - 9 | V |
| 29 d’oct. | Ligue 1 | Paris FC 3–3LyonRegular Season - 10 | E |
| novembre del 202502 de nov. | Ligue 1 | Stade Brestois 29 0–0LyonRegular Season - 11 | E |
| 06 de nov. | Europa League | Real Betis 2–0LyonLeague Stage - 4 | D |
| 09 de nov. | Ligue 1 | Lyon2–3 Paris Saint GermainRegular Season - 12 | D |
| 23 de nov. | Ligue 1 | Auxerre 0–0LyonRegular Season - 13 | E |
| 27 de nov. | Europa League | Maccabi Tel Aviv 0–6LyonLeague Stage - 5 | V |
| 30 de nov. | Ligue 1 | Lyon3–0 NantesRegular Season - 14 | V |
| desembre del 202507 de des. | Ligue 1 | Lorient 1–0LyonRegular Season - 15 | D |
| 11 de des. | Europa League | Lyon2–1 GO Ahead EaglesLeague Stage - 6 | V |
| 14 de des. | Ligue 1 | Lyon1–0 Le HavreRegular Season - 16 | V |
| gener del 202603 de gen. | Ligue 1 | Monaco 1–3LyonRegular Season - 17 | V |
| 18 de gen. | Ligue 1 | Lyon2–1Stade Brestois 29Regular Season - 18 | V |
| 22 de gen. | Europa League | BSC Young Boys 0–1LyonLeague Stage - 7 | V |
| 25 de gen. | Ligue 1 | Metz2–5LyonRegular Season - 19 | V |
| 29 de gen. | Europa League | Lyon4–2 PAOKLeague Stage - 8 | V |
| febrer del 202601 de febr. | Ligue 1 | Lyon1–0LilleRegular Season - 20 | V |
| 07 de febr. | Ligue 1 | Nantes0–1LyonRegular Season - 21 | V |
| 15 de febr. | Ligue 1 | Lyon2–0NiceRegular Season - 22 | V |
| 22 de febr. | Ligue 1 | Strasbourg3–1LyonRegular Season - 23 | D |
| març del 202601 de març | Ligue 1 | Marseille3–2LyonRegular Season - 24 | D |
| 08 de març | Ligue 1 | Lyon1–1Paris FCRegular Season - 25 | E |
| 12 de març | Europa League | Celta Vigo 1–1LyonRound of 16 | E |
| 15 de març | Ligue 1 | Le Havre0–0LyonRegular Season - 26 | E |
| 19 de març | Europa League | Lyon0–2Celta VigoRound of 16 | D |
| 22 de març | Ligue 1 | Lyon1–2MonacoRegular Season - 27 | D |
| abril del 202605 d’abr. | Ligue 1 | Angers0–0LyonRegular Season - 28 | E |
| 12 d’abr. | Ligue 1 | Lyon2–0LorientRegular Season - 29 | V |
| 19 d’abr. | Ligue 1 | Paris Saint Germain1–2LyonRegular Season - 30 | V |
| 25 d’abr. | Ligue 1 | Lyon3–2AuxerreRegular Season - 31 | V |
| maig del 202603 de maig | Ligue 1 | Lyon4–2RennesRegular Season - 32 | V |
| 10 de maig | Ligue 1 | Toulouse2–1LyonRegular Season - 33 | D |
| 17 de maig | Ligue 1 | Lyon0–4LensRegular Season - 34 | D |
