| agost del 202622 d’ag. |  Premier League | Hull City 11:30 Manchester UnitedRegular Season - 1 | — |
| 30 d’ag. | Premier League | Manchester United15:30 IpswichRegular Season - 2 | — |
| setembre del 202606 de set. | Premier League | Everton 13:00Manchester UnitedRegular Season - 3 | — |
| 13 de set. | Premier League | Manchester United15:30 Manchester CityRegular Season - 4 | — |
| 20 de set. | Premier League | Fulham 15:30Manchester UnitedRegular Season - 5 | — |
| octubre del 202610 d’oct. | Premier League | Manchester United14:00 TottenhamRegular Season - 6 | — |
| 17 d’oct. | Premier League | Leeds 14:00Manchester UnitedRegular Season - 7 | — |
| 24 d’oct. | Premier League | Manchester United14:00 BournemouthRegular Season - 8 | — |
| 31 d’oct. | Premier League | Chelsea 15:00Manchester UnitedRegular Season - 9 | — |
| novembre del 202607 de nov. | Premier League | Manchester United15:00 Aston VillaRegular Season - 10 | — |
| 21 de nov. | Premier League | Liverpool 15:00Manchester UnitedRegular Season - 11 | — |
| 28 de nov. | Premier League | Manchester United15:00 BrentfordRegular Season - 12 | — |
| desembre del 202602 de des. | Premier League | Newcastle 20:00Manchester UnitedRegular Season - 13 | — |
| 05 de des. | Premier League | Manchester United15:00 CoventryRegular Season - 14 | — |
| 12 de des. | Premier League | Crystal Palace 15:00Manchester UnitedRegular Season - 15 | — |
| 19 de des. | Premier League | Arsenal 15:00Manchester UnitedRegular Season - 16 | — |
| 26 de des. | Premier League | Manchester United15:00 Nottingham ForestRegular Season - 17 | — |
| 30 de des. | Premier League | Manchester United20:00 SunderlandRegular Season - 18 | — |
| gener del 202702 de gen. | Premier League | Brighton 15:00Manchester UnitedRegular Season - 19 | — |
| 06 de gen. | Premier League | Manchester United20:00NewcastleRegular Season - 20 | — |
| 16 de gen. | Premier League | Aston Villa15:00Manchester UnitedRegular Season - 21 | — |
| 23 de gen. | Premier League | Manchester United15:00LiverpoolRegular Season - 22 | — |
| 30 de gen. | Premier League | Brentford15:00Manchester UnitedRegular Season - 23 | — |
| febrer del 202706 de febr. | Premier League | Manchester United15:00ChelseaRegular Season - 24 | — |
| 10 de febr. | Premier League | Manchester United20:00BrightonRegular Season - 25 | — |
| 20 de febr. | Premier League | Nottingham Forest15:00Manchester UnitedRegular Season - 26 | — |
| 27 de febr. | Premier League | Manchester United15:00ArsenalRegular Season - 27 | — |
| març del 202703 de març | Premier League | Sunderland20:00Manchester UnitedRegular Season - 28 | — |
| 13 de març | Premier League | Manchester United15:00EvertonRegular Season - 29 | — |
| 20 de març | Premier League | Manchester City15:00Manchester UnitedRegular Season - 30 | — |
| abril del 202710 d’abr. | Premier League | Manchester United14:00Hull CityRegular Season - 31 | — |
| 17 d’abr. | Premier League | Ipswich14:00Manchester UnitedRegular Season - 32 | — |
| 24 d’abr. | Premier League | Manchester United14:00Crystal PalaceRegular Season - 33 | — |
| maig del 202701 de maig | Premier League | Coventry14:00Manchester UnitedRegular Season - 34 | — |
| 08 de maig | Premier League | Bournemouth14:00Manchester UnitedRegular Season - 35 | — |
| 15 de maig | Premier League | Manchester United14:00LeedsRegular Season - 36 | — |
| 23 de maig | Premier League | Tottenham14:00Manchester UnitedRegular Season - 37 | — |
| 30 de maig | Premier League | Manchester United15:00FulhamRegular Season - 38 | — |
