| agost del 202516 d’ag. |  Premier League | Aston Villa 0–0 NewcastleRegular Season - 1 | E |
| 25 d’ag. | Premier League | Newcastle2–3 LiverpoolRegular Season - 2 | D |
| 30 d’ag. | Premier League | Leeds 0–0NewcastleRegular Season - 3 | E |
| setembre del 202513 de set. | Premier League | Newcastle1–0 WolvesRegular Season - 4 | V |
| 18 de set. |  Champions League | Newcastle1–2 BarcelonaLeague Stage - 1 | D |
| 21 de set. | Premier League | Bournemouth 0–0NewcastleRegular Season - 5 | E |
| 28 de set. | Premier League | Newcastle1–2 ArsenalRegular Season - 6 | D |
| octubre del 202501 d’oct. | Champions League | Union St. Gilloise 0–4NewcastleLeague Stage - 2 | V |
| 05 d’oct. | Premier League | Newcastle2–0 Nottingham ForestRegular Season - 7 | V |
| 18 d’oct. | Premier League | Brighton 2–1NewcastleRegular Season - 8 | D |
| 21 d’oct. | Champions League | Newcastle3–0 BenficaLeague Stage - 3 | V |
| 25 d’oct. | Premier League | Newcastle2–1 FulhamRegular Season - 9 | V |
| novembre del 202502 de nov. | Premier League | West Ham 3–1NewcastleRegular Season - 10 | D |
| 05 de nov. | Champions League | Newcastle2–0 Athletic ClubLeague Stage - 4 | V |
| 09 de nov. | Premier League | Brentford 3–1NewcastleRegular Season - 11 | D |
| 22 de nov. | Premier League | Newcastle2–1 Manchester CityRegular Season - 12 | V |
| 25 de nov. | Champions League | Marseille 2–1NewcastleLeague Stage - 5 | D |
| 29 de nov. | Premier League | Everton 1–4NewcastleRegular Season - 13 | V |
| desembre del 202502 de des. | Premier League | Newcastle2–2 TottenhamRegular Season - 14 | E |
| 06 de des. | Premier League | Newcastle2–1 BurnleyRegular Season - 15 | V |
| 10 de des. | Champions League | Bayer Leverkusen 2–2NewcastleLeague Stage - 6 | E |
| 14 de des. | Premier League | Sunderland 1–0NewcastleRegular Season - 16 | D |
| 20 de des. | Premier League | Newcastle2–2 ChelseaRegular Season - 17 | E |
| 26 de des. | Premier League | Manchester United 1–0NewcastleRegular Season - 18 | D |
| 30 de des. | Premier League | Burnley1–3NewcastleRegular Season - 19 | V |
| gener del 202604 de gen. | Premier League | Newcastle2–0 Crystal PalaceRegular Season - 20 | V |
| 07 de gen. | Premier League | Newcastle4–3LeedsRegular Season - 21 | V |
| 18 de gen. | Premier League | Wolves0–0NewcastleRegular Season - 22 | E |
| 21 de gen. | Champions League | Newcastle3–0 PSV EindhovenLeague Stage - 7 | V |
| 25 de gen. | Premier League | Newcastle0–2Aston VillaRegular Season - 23 | D |
| 28 de gen. | Champions League | Paris Saint Germain 1–1NewcastleLeague Stage - 8 | E |
| 31 de gen. | Premier League | Liverpool4–1NewcastleRegular Season - 24 | D |
| febrer del 202607 de febr. | Premier League | Newcastle2–3BrentfordRegular Season - 25 | D |
| 10 de febr. | Premier League | Tottenham1–2NewcastleRegular Season - 26 | V |
| 18 de febr. | Champions League | Qarabag 1–6NewcastleRound of 32 | V |
| 21 de febr. | Premier League | Manchester City2–1NewcastleRegular Season - 27 | D |
| 24 de febr. | Champions League | Newcastle3–2QarabagRound of 32 | V |
| 28 de febr. | Premier League | Newcastle2–3EvertonRegular Season - 28 | D |
| març del 202604 de març | Premier League | Newcastle2–1Manchester UnitedRegular Season - 29 | V |
| 10 de març | Champions League | Newcastle1–1BarcelonaRound of 16 | E |
| 14 de març | Premier League | Chelsea0–1NewcastleRegular Season - 30 | V |
| 18 de març | Champions League | Barcelona7–2NewcastleRound of 16 | D |
| 22 de març | Premier League | Newcastle1–2SunderlandRegular Season - 31 | D |
| abril del 202612 d’abr. | Premier League | Crystal Palace2–1NewcastleRegular Season - 32 | D |
| 18 d’abr. | Premier League | Newcastle1–2BournemouthRegular Season - 33 | D |
| 25 d’abr. | Premier League | Arsenal1–0NewcastleRegular Season - 34 | D |
| maig del 202602 de maig | Premier League | Newcastle3–1BrightonRegular Season - 35 | V |
| 10 de maig | Premier League | Nottingham Forest1–1NewcastleRegular Season - 36 | E |
| 17 de maig | Premier League | Newcastle3–1West HamRegular Season - 37 | V |
| 24 de maig | Premier League | Fulham2–0NewcastleRegular Season - 38 | D |
