| agost del 202417 d’ag. |  Premier League | Newcastle 1–0 SouthamptonRegular Season - 1 | D |
| 24 d’ag. | Premier League | Southampton0–1 Nottingham ForestRegular Season - 2 | D |
| 31 d’ag. | Premier League | Brentford 3–1SouthamptonRegular Season - 3 | D |
| setembre del 202414 de set. | Premier League | Southampton0–3 Manchester UnitedRegular Season - 4 | D |
| 21 de set. | Premier League | Southampton1–1 IpswichRegular Season - 5 | E |
| 30 de set. | Premier League | Bournemouth 3–1SouthamptonRegular Season - 6 | D |
| octubre del 202405 d’oct. | Premier League | Arsenal 3–1SouthamptonRegular Season - 7 | D |
| 19 d’oct. | Premier League | Southampton2–3 LeicesterRegular Season - 8 | D |
| 26 d’oct. | Premier League | Manchester City 1–0SouthamptonRegular Season - 9 | D |
| novembre del 202402 de nov. | Premier League | Southampton1–0 EvertonRegular Season - 10 | V |
| 09 de nov. | Premier League | Wolves 2–0SouthamptonRegular Season - 11 | D |
| 24 de nov. | Premier League | Southampton2–3 LiverpoolRegular Season - 12 | D |
| 29 de nov. | Premier League | Brighton 1–1SouthamptonRegular Season - 13 | E |
| desembre del 202404 de des. | Premier League | Southampton1–5 ChelseaRegular Season - 14 | D |
| 07 de des. | Premier League | Aston Villa 1–0SouthamptonRegular Season - 15 | D |
| 15 de des. | Premier League | Southampton0–5 TottenhamRegular Season - 16 | D |
| 22 de des. | Premier League | Fulham 0–0SouthamptonRegular Season - 17 | E |
| 26 de des. | Premier League | Southampton0–1 West HamRegular Season - 18 | D |
| 29 de des. | Premier League | Crystal Palace 2–1SouthamptonRegular Season - 19 | D |
| gener del 202504 de gen. | Premier League | Southampton0–5BrentfordRegular Season - 20 | D |
| 16 de gen. | Premier League | Manchester United3–1SouthamptonRegular Season - 21 | D |
| 19 de gen. | Premier League | Nottingham Forest3–2SouthamptonRegular Season - 22 | D |
| 25 de gen. | Premier League | Southampton1–3NewcastleRegular Season - 23 | D |
| febrer del 202501 de febr. | Premier League | Ipswich1–2SouthamptonRegular Season - 24 | V |
| 15 de febr. | Premier League | Southampton1–3BournemouthRegular Season - 25 | D |
| 22 de febr. | Premier League | Southampton0–4BrightonRegular Season - 26 | D |
| 25 de febr. | Premier League | Chelsea4–0SouthamptonRegular Season - 27 | D |
| març del 202508 de març | Premier League | Liverpool3–1SouthamptonRegular Season - 28 | D |
| 15 de març | Premier League | Southampton1–2WolvesRegular Season - 29 | D |
| abril del 202502 d’abr. | Premier League | Southampton1–1Crystal PalaceRegular Season - 30 | E |
| 06 d’abr. | Premier League | Tottenham3–1SouthamptonRegular Season - 31 | D |
| 12 d’abr. | Premier League | Southampton0–3Aston VillaRegular Season - 32 | D |
| 19 d’abr. | Premier League | West Ham1–1SouthamptonRegular Season - 33 | E |
| 26 d’abr. | Premier League | Southampton1–2FulhamRegular Season - 34 | D |
| maig del 202503 de maig | Premier League | Leicester2–0SouthamptonRegular Season - 35 | D |
| 10 de maig | Premier League | Southampton0–0Manchester CityRegular Season - 36 | E |
| 18 de maig | Premier League | Everton2–0SouthamptonRegular Season - 37 | D |
| 25 de maig | Premier League | Southampton1–2ArsenalRegular Season - 38 | D |
