| agosto de 202523 ago |  Serie A | Genoa 0–0 LecceRegular Season - 1 | E |
| 31 ago | Serie A | Genoa0–1 JuventusRegular Season - 2 | D |
| septiembre de 202515 sept | Serie A | Como 1–1GenoaRegular Season - 3 | E |
| 20 sept | Serie A | Bologna 2–1GenoaRegular Season - 4 | D |
| 29 sept | Serie A | Genoa0–3 LazioRegular Season - 5 | D |
| octubre de 202505 oct | Serie A | Napoli 2–1GenoaRegular Season - 6 | D |
| 19 oct | Serie A | Genoa0–0 ParmaRegular Season - 7 | E |
| 26 oct | Serie A | Torino 2–1GenoaRegular Season - 8 | D |
| 29 oct | Serie A | Genoa0–2 CremoneseRegular Season - 9 | D |
| noviembre de 202503 nov | Serie A | Sassuolo 1–2GenoaRegular Season - 10 | V |
| 09 nov | Serie A | Genoa2–2 FiorentinaRegular Season - 11 | E |
| 22 nov | Serie A | Cagliari 3–3GenoaRegular Season - 12 | E |
| 29 nov | Serie A | Genoa2–1 Hellas VeronaRegular Season - 13 | V |
| diciembre de 202508 dic | Serie A | Udinese 1–2GenoaRegular Season - 14 | V |
| 14 dic | Serie A | Genoa1–2 InterRegular Season - 15 | D |
| 21 dic | Serie A | Genoa0–1 AtalantaRegular Season - 16 | D |
| 29 dic | Serie A | AS Roma 3–1GenoaRegular Season - 17 | D |
| enero de 202603 ene | Serie A | Genoa1–1 PisaRegular Season - 18 | E |
| 08 ene | Serie A | AC Milan 1–1GenoaRegular Season - 19 | E |
| 12 ene | Serie A | Genoa3–0CagliariRegular Season - 20 | V |
| 18 ene | Serie A | Parma0–0GenoaRegular Season - 21 | E |
| 25 ene | Serie A | Genoa3–2BolognaRegular Season - 22 | V |
| 30 ene | Serie A | Lazio3–2GenoaRegular Season - 23 | D |
| febrero de 202607 feb | Serie A | Genoa2–3NapoliRegular Season - 24 | D |
| 15 feb | Serie A | Cremonese0–0GenoaRegular Season - 25 | E |
| 22 feb | Serie A | Genoa3–0TorinoRegular Season - 26 | V |
| 28 feb | Serie A | Inter2–0GenoaRegular Season - 27 | D |
| marzo de 202608 mar | Serie A | Genoa2–1AS RomaRegular Season - 28 | V |
| 15 mar | Serie A | Hellas Verona0–2GenoaRegular Season - 29 | V |
| 20 mar | Serie A | Genoa0–2UdineseRegular Season - 30 | D |
| abril de 202606 abr | Serie A | Juventus2–0GenoaRegular Season - 31 | D |
| 12 abr | Serie A | Genoa2–1SassuoloRegular Season - 32 | V |
| 19 abr | Serie A | Pisa1–2GenoaRegular Season - 33 | V |
| 26 abr | Serie A | Genoa0–2ComoRegular Season - 34 | D |
| mayo de 202602 may | Serie A | Atalanta0–0GenoaRegular Season - 35 | E |
| 10 may | Serie A | Fiorentina0–0GenoaRegular Season - 36 | E |
| 17 may | Serie A | Genoa1–2AC MilanRegular Season - 37 | D |
| 24 may | Serie A | Lecce1–0GenoaRegular Season - 38 | D |
