| agosto de 202516 ago |  Coppa Italia | Cremonese 0–0 Palermo1st Round | E |
| 23 ago |  Serie B | Palermo2–1 ReggianaRegular Season - 1 | V |
| 30 ago | Serie B | Palermo0–0 FrosinoneRegular Season - 2 | E |
| septiembre de 202514 sept | Serie B | Sudtirol 0–2PalermoRegular Season - 3 | V |
| 19 sept | Serie B | Palermo2–0 BariRegular Season - 4 | V |
| 23 sept | Coppa Italia | Udinese 2–1Palermo2nd Round | D |
| 27 sept | Serie B | Cesena 1–1PalermoRegular Season - 5 | E |
| 30 sept | Serie B | Palermo0–0 VeneziaRegular Season - 6 | E |
| octubre de 202504 oct | Serie B | Spezia 1–2PalermoRegular Season - 7 | V |
| 19 oct | Serie B | Palermo1–1 ModenaRegular Season - 8 | E |
| 25 oct | Serie B | Catanzaro 1–0PalermoRegular Season - 9 | D |
| 28 oct | Serie B | Palermo0–3 MonzaRegular Season - 10 | D |
| noviembre de 202501 nov | Serie B | Palermo5–0 PescaraRegular Season - 11 | V |
| 08 nov | Serie B | Juve Stabia 1–0PalermoRegular Season - 12 | D |
| 22 nov | Serie B | Virtus Entella 1–1PalermoRegular Season - 13 | E |
| 29 nov | Serie B | Palermo5–0 CarrareseRegular Season - 14 | V |
| diciembre de 202507 dic | Serie B | Empoli 1–3PalermoRegular Season - 15 | V |
| 12 dic | Serie B | Palermo1–0 SampdoriaRegular Season - 16 | V |
| 20 dic | Serie B | Avellino 2–2PalermoRegular Season - 17 | E |
| 27 dic | Serie B | Palermo1–0 PadovaRegular Season - 18 | V |
| enero de 202611 ene | Serie B | Mantova 1–1PalermoRegular Season - 19 | E |
| 18 ene | Serie B | Palermo1–0SpeziaRegular Season - 20 | V |
| 24 ene | Serie B | Modena0–0PalermoRegular Season - 21 | E |
| 30 ene | Serie B | Bari0–3PalermoRegular Season - 22 | V |
| febrero de 202607 feb | Serie B | Palermo3–2EmpoliRegular Season - 23 | V |
| 10 feb | Serie B | Sampdoria3–3PalermoRegular Season - 24 | E |
| 14 feb | Serie B | Palermo3–0Virtus EntellaRegular Season - 25 | V |
| 21 feb | Serie B | Palermo3–0SudtirolRegular Season - 26 | V |
| marzo de 202601 mar | Serie B | Pescara2–1PalermoRegular Season - 27 | D |
| 04 mar | Serie B | Palermo2–1MantovaRegular Season - 28 | V |
| 08 mar | Serie B | Carrarese0–1PalermoRegular Season - 29 | V |
| 14 mar | Serie B | Monza3–0PalermoRegular Season - 30 | D |
| 17 mar | Serie B | Palermo2–2Juve StabiaRegular Season - 31 | E |
| 21 mar | Serie B | Padova0–1PalermoRegular Season - 32 | V |
| abril de 202605 abr | Serie B | Palermo2–0AvellinoRegular Season - 33 | V |
| 10 abr | Serie B | Frosinone1–1PalermoRegular Season - 34 | E |
| 18 abr | Serie B | Palermo2–0CesenaRegular Season - 35 | V |
| 25 abr | Serie B | Reggiana1–1PalermoRegular Season - 36 | E |
| mayo de 202601 may | Serie B | Palermo3–2CatanzaroRegular Season - 37 | V |
| 08 may | Serie B | Venezia2–0PalermoRegular Season - 38 | D |
| 17 may | Serie B | Catanzaro3–0PalermoSemi-finals | D |
| 20 may | Serie B | Palermo2–0CatanzaroSemi-finals | V |
