| August 2021Aug 16 |  LaLiga | Elche 0–0 Athletic ClubRegular Season - 1 | D |
| Aug 22 | LaLiga | Atletico Madrid 1–0ElcheRegular Season - 2 | L |
| Aug 28 | LaLiga | Elche1–1 SevillaRegular Season - 3 | D |
| September 2021Sep 13 | LaLiga | Getafe 0–1ElcheRegular Season - 4 | W |
| Sep 18 | LaLiga | Elche1–1 LevanteRegular Season - 5 | D |
| Sep 22 | LaLiga | Villarreal 4–1ElcheRegular Season - 6 | L |
| Sep 26 | LaLiga | Real Sociedad 1–0ElcheRegular Season - 7 | L |
| October 2021Oct 03 | LaLiga | Elche1–0 Celta VigoRegular Season - 8 | W |
| Oct 17 | LaLiga | Rayo Vallecano 2–1ElcheRegular Season - 9 | L |
| Oct 23 | LaLiga | Elche2–2 EspanyolRegular Season - 10 | D |
| Oct 26 | LaLiga | Alaves 1–0ElcheRegular Season - 11 | L |
| Oct 30 | LaLiga | Elche1–2 Real MadridRegular Season - 12 | L |
| November 2021Nov 07 | LaLiga | Mallorca 2–2ElcheRegular Season - 13 | D |
| Nov 21 | LaLiga | Elche0–3 Real BetisRegular Season - 14 | L |
| Nov 29 | LaLiga | Osasuna 1–1ElcheRegular Season - 15 | D |
| December 2021Dec 02 |  Copa del Rey | Leioa 0–2Elche1st Round | W |
| Dec 05 | LaLiga | Elche3–1 CadizRegular Season - 16 | W |
| Dec 11 | LaLiga | Valencia 2–1ElcheRegular Season - 17 | L |
| Dec 15 | Copa del Rey | Unionistas de Salamanca 0–1Elche2nd Round | W |
| Dec 18 | LaLiga | Barcelona 3–2ElcheRegular Season - 18 | L |
| January 2022Jan 02 | LaLiga | Elche0–0 Granada CFRegular Season - 19 | D |
| Jan 06 | Copa del Rey | Almeria 1–2ElcheRound of 32 | W |
| Jan 10 | LaLiga | Espanyol1–2ElcheRegular Season - 20 | W |
| Jan 16 | LaLiga | Elche1–0VillarrealRegular Season - 21 | W |
| Jan 20 | Copa del Rey | Elche1–2Real MadridRound of 16 | L |
| Jan 23 | LaLiga | Real Madrid2–2ElcheRegular Season - 22 | D |
| February 2022Feb 05 | LaLiga | Elche3–1AlavesRegular Season - 23 | W |
| Feb 11 | LaLiga | Sevilla2–0ElcheRegular Season - 24 | L |
| Feb 18 | LaLiga | Elche2–1Rayo VallecanoRegular Season - 25 | W |
| Feb 25 | LaLiga | Levante3–0ElcheRegular Season - 26 | L |
| March 2022Mar 06 | LaLiga | Elche1–2BarcelonaRegular Season - 27 | L |
| Mar 12 | LaLiga | Granada CF0–1ElcheRegular Season - 28 | W |
| Mar 19 | LaLiga | Elche0–1ValenciaRegular Season - 29 | L |
| April 2022Apr 03 | LaLiga | Athletic Club2–1ElcheRegular Season - 30 | L |
| Apr 10 | LaLiga | Elche1–2Real SociedadRegular Season - 31 | L |
| Apr 16 | LaLiga | Elche3–0MallorcaRegular Season - 32 | W |
| Apr 19 | LaLiga | Real Betis0–1ElcheRegular Season - 33 | W |
| May 2022May 01 | LaLiga | Elche1–1OsasunaRegular Season - 34 | D |
| May 07 | LaLiga | Cadiz3–0ElcheRegular Season - 35 | L |
| May 11 | LaLiga | Elche0–2Atletico MadridRegular Season - 36 | L |
| May 15 | LaLiga | Celta Vigo1–0ElcheRegular Season - 37 | L |
| May 22 | LaLiga | Elche3–1GetafeRegular Season - 38 | W |
