| August 2025Aug 23 |  Serie A | Genoa 0–0 LecceRegular Season - 1 | D |
| Aug 31 | Serie A | Genoa0–1 JuventusRegular Season - 2 | L |
| September 2025Sep 15 | Serie A | Como 1–1GenoaRegular Season - 3 | D |
| Sep 20 | Serie A | Bologna 2–1GenoaRegular Season - 4 | L |
| Sep 29 | Serie A | Genoa0–3 LazioRegular Season - 5 | L |
| October 2025Oct 05 | Serie A | Napoli 2–1GenoaRegular Season - 6 | L |
| Oct 19 | Serie A | Genoa0–0 ParmaRegular Season - 7 | D |
| Oct 26 | Serie A | Torino 2–1GenoaRegular Season - 8 | L |
| Oct 29 | Serie A | Genoa0–2 CremoneseRegular Season - 9 | L |
| November 2025Nov 03 | Serie A | Sassuolo 1–2GenoaRegular Season - 10 | W |
| Nov 09 | Serie A | Genoa2–2 FiorentinaRegular Season - 11 | D |
| Nov 22 | Serie A | Cagliari 3–3GenoaRegular Season - 12 | D |
| Nov 29 | Serie A | Genoa2–1 Hellas VeronaRegular Season - 13 | W |
| December 2025Dec 08 | Serie A | Udinese 1–2GenoaRegular Season - 14 | W |
| Dec 14 | Serie A | Genoa1–2 InterRegular Season - 15 | L |
| Dec 21 | Serie A | Genoa0–1 AtalantaRegular Season - 16 | L |
| Dec 29 | Serie A | AS Roma 3–1GenoaRegular Season - 17 | L |
| January 2026Jan 03 | Serie A | Genoa1–1 PisaRegular Season - 18 | D |
| Jan 08 | Serie A | AC Milan 1–1GenoaRegular Season - 19 | D |
| Jan 12 | Serie A | Genoa3–0CagliariRegular Season - 20 | W |
| Jan 18 | Serie A | Parma0–0GenoaRegular Season - 21 | D |
| Jan 25 | Serie A | Genoa3–2BolognaRegular Season - 22 | W |
| Jan 30 | Serie A | Lazio3–2GenoaRegular Season - 23 | L |
| February 2026Feb 07 | Serie A | Genoa2–3NapoliRegular Season - 24 | L |
| Feb 15 | Serie A | Cremonese0–0GenoaRegular Season - 25 | D |
| Feb 22 | Serie A | Genoa3–0TorinoRegular Season - 26 | W |
| Feb 28 | Serie A | Inter2–0GenoaRegular Season - 27 | L |
| March 2026Mar 08 | Serie A | Genoa2–1AS RomaRegular Season - 28 | W |
| Mar 15 | Serie A | Hellas Verona0–2GenoaRegular Season - 29 | W |
| Mar 20 | Serie A | Genoa0–2UdineseRegular Season - 30 | L |
| April 2026Apr 06 | Serie A | Juventus2–0GenoaRegular Season - 31 | L |
| Apr 12 | Serie A | Genoa2–1SassuoloRegular Season - 32 | W |
| Apr 19 | Serie A | Pisa1–2GenoaRegular Season - 33 | W |
| Apr 26 | Serie A | Genoa0–2ComoRegular Season - 34 | L |
| May 2026May 02 | Serie A | Atalanta0–0GenoaRegular Season - 35 | D |
| May 10 | Serie A | Fiorentina0–0GenoaRegular Season - 36 | D |
| May 17 | Serie A | Genoa1–2AC MilanRegular Season - 37 | L |
| May 24 | Serie A | Lecce1–0GenoaRegular Season - 38 | L |
