| August 2021Aug 13 |  LaLiga | Valencia 1–0 GetafeRegular Season - 1 | L |
| Aug 23 | LaLiga | Getafe0–1 SevillaRegular Season - 2 | L |
| Aug 29 | LaLiga | Barcelona 2–1GetafeRegular Season - 3 | L |
| September 2021Sep 13 | LaLiga | Getafe0–1 ElcheRegular Season - 4 | L |
| Sep 18 | LaLiga | Rayo Vallecano 3–0GetafeRegular Season - 5 | L |
| Sep 21 | LaLiga | Getafe1–2 Atletico MadridRegular Season - 6 | L |
| Sep 26 | LaLiga | Real Betis 2–0GetafeRegular Season - 7 | L |
| October 2021Oct 03 | LaLiga | Getafe1–1 Real SociedadRegular Season - 8 | D |
| Oct 16 | LaLiga | Levante 0–0GetafeRegular Season - 9 | D |
| Oct 25 | LaLiga | Getafe0–3 Celta VigoRegular Season - 10 | L |
| Oct 28 | LaLiga | Granada CF 1–1GetafeRegular Season - 11 | D |
| Oct 31 | LaLiga | Getafe2–1 EspanyolRegular Season - 12 | W |
| November 2021Nov 07 | LaLiga | Villarreal 1–0GetafeRegular Season - 13 | L |
| Nov 21 | LaLiga | Getafe4–0 CadizRegular Season - 14 | W |
| Nov 27 | LaLiga | Mallorca 0–0GetafeRegular Season - 15 | D |
| Nov 30 |  Copa del Rey | Mollerussa 1–5Getafe1st Round | W |
| December 2021Dec 06 | LaLiga | Getafe0–0 Athletic ClubRegular Season - 16 | D |
| Dec 11 | LaLiga | Alaves 1–1GetafeRegular Season - 17 | D |
| Dec 16 | Copa del Rey | Atlético Baleares 5–0Getafe2nd Round | L |
| Dec 19 | LaLiga | Getafe1–0 OsasunaRegular Season - 18 | W |
| January 2022Jan 02 | LaLiga | Getafe1–0 Real MadridRegular Season - 19 | W |
| Jan 09 | LaLiga | Sevilla1–0GetafeRegular Season - 20 | L |
| Jan 20 | LaLiga | Getafe4–2Granada CFRegular Season - 21 | W |
| Jan 23 | LaLiga | Real Sociedad0–0GetafeRegular Season - 22 | D |
| February 2022Feb 04 | LaLiga | Getafe3–0LevanteRegular Season - 23 | W |
| Feb 12 | LaLiga | Atletico Madrid4–3GetafeRegular Season - 24 | L |
| Feb 19 | LaLiga | Cadiz1–1GetafeRegular Season - 25 | D |
| Feb 26 | LaLiga | Getafe2–2AlavesRegular Season - 26 | D |
| March 2022Mar 05 | LaLiga | Espanyol2–0GetafeRegular Season - 27 | L |
| Mar 12 | LaLiga | Getafe0–0ValenciaRegular Season - 28 | D |
| Mar 18 | LaLiga | Athletic Club1–1GetafeRegular Season - 29 | D |
| April 2022Apr 02 | LaLiga | Getafe1–0MallorcaRegular Season - 30 | W |
| Apr 09 | LaLiga | Real Madrid2–0GetafeRegular Season - 31 | L |
| Apr 16 | LaLiga | Getafe1–2VillarrealRegular Season - 32 | L |
| Apr 20 | LaLiga | Celta Vigo0–2GetafeRegular Season - 33 | W |
| May 2022May 02 | LaLiga | Getafe0–0Real BetisRegular Season - 34 | D |
| May 08 | LaLiga | Getafe0–0Rayo VallecanoRegular Season - 35 | D |
| May 11 | LaLiga | Osasuna1–1GetafeRegular Season - 36 | D |
| May 15 | LaLiga | Getafe0–0BarcelonaRegular Season - 37 | D |
| May 22 | LaLiga | Elche3–1GetafeRegular Season - 38 | L |
