| July 2022Jul 30 |  Ligue 2 | Guingamp 4–0 PAURegular Season - 1 | W |
| August 2022Aug 06 | Ligue 2 | Laval 1–2GuingampRegular Season - 2 | W |
| Aug 13 | Ligue 2 | Guingamp0–0 Paris FCRegular Season - 3 | D |
| Aug 20 | Ligue 2 | Caen 4–1GuingampRegular Season - 4 | L |
| Aug 27 | Ligue 2 | Bordeaux 0–1GuingampRegular Season - 5 | W |
| Aug 30 | Ligue 2 | Guingamp1–2 SochauxRegular Season - 6 | L |
| September 2022Sep 12 | Ligue 2 | Metz 3–6GuingampRegular Season - 8 | W |
| Sep 17 | Ligue 2 | Guingamp2–1 Saint EtienneRegular Season - 9 | W |
| October 2022Oct 01 | Ligue 2 | Niort 0–0GuingampRegular Season - 10 | D |
| Oct 04 | Ligue 2 | Guingamp0–0 RodezRegular Season - 7 | D |
| Oct 08 | Ligue 2 | Guingamp0–4 AnnecyRegular Season - 11 | L |
| Oct 15 | Ligue 2 | Valenciennes 1–0GuingampRegular Season - 12 | L |
| Oct 22 | Ligue 2 | Guingamp1–1 BastiaRegular Season - 13 | D |
| Oct 30 |  Coupe de France | Auray 0–2Guingamp7th Round | W |
| November 2022Nov 05 | Ligue 2 | Dijon 1–1GuingampRegular Season - 14 | D |
| Nov 12 | Ligue 2 | Guingamp0–1 Le HavreRegular Season - 15 | L |
| Nov 19 | Coupe de France | Les Herbiers 2–2Guingamp8th Round | D |
| December 2022Dec 26 | Ligue 2 | Nimes 1–2GuingampRegular Season - 16 | W |
| Dec 30 | Ligue 2 | Guingamp0–2 QuevillyRegular Season - 17 | L |
| January 2023Jan 10 | Ligue 2 | Amiens 1–1GuingampRegular Season - 18 | D |
| Jan 13 | Ligue 2 | Guingamp2–4 GrenobleRegular Season - 19 | L |
| Jan 28 | Ligue 2 | Rodez0–1GuingampRegular Season - 20 | W |
| Jan 31 | Ligue 2 | Guingamp1–2NimesRegular Season - 21 | L |
| February 2023Feb 03 | Ligue 2 | Quevilly2–0GuingampRegular Season - 22 | L |
| Feb 11 | Ligue 2 | Guingamp3–1ValenciennesRegular Season - 23 | W |
| Feb 18 | Ligue 2 | Bastia1–1GuingampRegular Season - 24 | D |
| Feb 25 | Ligue 2 | Guingamp1–2CaenRegular Season - 25 | L |
| March 2023Mar 04 | Ligue 2 | Paris FC1–2GuingampRegular Season - 26 | W |
| Mar 11 | Ligue 2 | Guingamp2–0DijonRegular Season - 27 | W |
| Mar 18 | Ligue 2 | Annecy1–1GuingampRegular Season - 28 | D |
| April 2023Apr 03 | Ligue 2 | Guingamp0–1BordeauxRegular Season - 29 | L |
| Apr 08 | Ligue 2 | Le Havre0–0GuingampRegular Season - 30 | D |
| Apr 15 | Ligue 2 | Guingamp3–1AmiensRegular Season - 31 | W |
| Apr 22 | Ligue 2 | PAU2–1GuingampRegular Season - 32 | L |
| Apr 29 | Ligue 2 | Guingamp3–1LavalRegular Season - 33 | W |
| May 2023May 06 | Ligue 2 | Saint Etienne3–2GuingampRegular Season - 34 | L |
| May 13 | Ligue 2 | Sochaux0–1GuingampRegular Season - 35 | W |
| May 20 | Ligue 2 | Guingamp1–1MetzRegular Season - 36 | D |
| May 26 | Ligue 2 | Guingamp2–0NiortRegular Season - 37 | W |
| June 2023Jun 02 | Ligue 2 | Grenoble0–2GuingampRegular Season - 38 | W |
