| February 2022Feb 12 |  Liga Profesional Argentina | Huracan 1–0 Lanus1st Phase - 1 | L |
| Feb 16 | Liga Profesional Argentina | Lanus2–0 Barracas Central1st Phase - 2 | W |
| Feb 19 | Liga Profesional Argentina | Estudiantes L.P. 2–1Lanus1st Phase - 3 | L |
| Feb 23 |  Copa Argentina | Lanus5–0 Defensores de Cambaceres1st Round | W |
| March 2022Mar 01 | Liga Profesional Argentina | Lanus0–0 Tigre1st Phase - 4 | D |
| Mar 07 | Liga Profesional Argentina | Arsenal Sarandi 2–2Lanus1st Phase - 5 | D |
| Mar 13 | Liga Profesional Argentina | Lanus1–1 Colon Santa Fe1st Phase - 6 | D |
| Mar 19 | Liga Profesional Argentina | Lanus0–1 Banfield1st Phase - 7 | L |
| April 2022Apr 02 | Liga Profesional Argentina | Velez Sarsfield 3–1Lanus1st Phase - 8 | L |
| Apr 08 |  Copa Sudamericana | Metropolitanos FC 0–0LanusGroup Stage - 1 | D |
| Apr 12 | Liga Profesional Argentina | Lanus1–2 Aldosivi1st Phase - 9 | L |
| Apr 15 | Copa Sudamericana | Lanus3–1 Barcelona SCGroup Stage - 2 | W |
| Apr 18 | Liga Profesional Argentina | Boca Juniors 1–1Lanus1st Phase - 10 | D |
| Apr 21 | Liga Profesional Argentina | Lanus3–1 Rosario Central1st Phase - 11 | W |
| Apr 25 | Liga Profesional Argentina | Godoy Cruz 1–1Lanus1st Phase - 12 | D |
| Apr 29 | Copa Sudamericana | Wanderers 0–1LanusGroup Stage - 3 | W |
| May 2022May 01 | Liga Profesional Argentina | Lanus1–0 Independiente1st Phase - 13 | W |
| May 05 | Copa Sudamericana | Barcelona SC1–1LanusGroup Stage - 4 | D |
| May 10 | Liga Profesional Argentina | Central Cordoba de Santiago 3–3Lanus1st Phase - 14 | D |
| May 20 | Copa Sudamericana | Lanus1–2WanderersGroup Stage - 5 | L |
| May 26 | Copa Sudamericana | Lanus1–0Metropolitanos FCGroup Stage - 6 | W |
| June 2022Jun 07 | Liga Profesional Argentina | Rosario Central0–0Lanus2nd Phase - 1 | D |
| Jun 11 | Liga Profesional Argentina | Lanus1–1 Defensa Y Justicia2nd Phase - 2 | D |
| Jun 15 | Liga Profesional Argentina | Atletico Tucuman 2–1Lanus2nd Phase - 3 | L |
| Jun 19 | Liga Profesional Argentina | Lanus1–0Colon Santa Fe2nd Phase - 4 | W |
| Jun 26 | Liga Profesional Argentina | River Plate 2–1Lanus2nd Phase - 5 | L |
| July 2022Jul 01 | Copa Sudamericana | Independiente del Valle 2–1LanusRound of 16 | L |
| Jul 03 | Liga Profesional Argentina | Union Santa Fe 3–0Lanus2nd Phase - 6 | L |
| Jul 08 | Copa Sudamericana | Lanus0–0Independiente del ValleRound of 16 | D |
| Jul 10 | Liga Profesional Argentina | Lanus2–3Huracan2nd Phase - 7 | L |
| Jul 13 | Copa Argentina | Lanus1–3Godoy CruzRound of 32 | L |
| Jul 17 | Liga Profesional Argentina | Godoy Cruz2–1Lanus2nd Phase - 8 | L |
| Jul 21 | Liga Profesional Argentina | Lanus2–2Velez Sarsfield2nd Phase - 9 | D |
| Jul 24 | Liga Profesional Argentina | Gimnasia L.P. 1–0Lanus2nd Phase - 10 | L |
| Jul 31 | Liga Profesional Argentina | Lanus0–1Aldosivi2nd Phase - 11 | L |
| August 2022Aug 06 | Liga Profesional Argentina | Sarmiento Junin 2–1Lanus2nd Phase - 12 | L |
| Aug 13 | Liga Profesional Argentina | Lanus1–1Independiente2nd Phase - 13 | D |
| Aug 17 | Liga Profesional Argentina | Newells Old Boys 2–0Lanus2nd Phase - 14 | L |
| Aug 21 | Liga Profesional Argentina | Lanus1–0Arsenal Sarandi2nd Phase - 15 | W |
| Aug 26 | Liga Profesional Argentina | Central Cordoba de Santiago2–2Lanus2nd Phase - 16 | D |
| September 2022Sep 03 | Liga Profesional Argentina | Lanus1–2Tigre2nd Phase - 17 | L |
| Sep 09 | Liga Profesional Argentina | Barracas Central2–0Lanus2nd Phase - 18 | L |
| Sep 15 | Liga Profesional Argentina | Lanus0–1Boca Juniors2nd Phase - 19 | L |
| Sep 18 | Liga Profesional Argentina | Banfield1–2Lanus2nd Phase - 20 | W |
| Sep 24 | Liga Profesional Argentina | Lanus2–0 San Lorenzo2nd Phase - 21 | W |
| October 2022Oct 02 | Liga Profesional Argentina | Talleres Cordoba 0–1Lanus2nd Phase - 22 | W |
| Oct 07 | Liga Profesional Argentina | Lanus0–4 Argentinos JRS2nd Phase - 23 | L |
| Oct 11 | Liga Profesional Argentina | Estudiantes L.P.3–1Lanus2nd Phase - 24 | L |
| Oct 14 | Liga Profesional Argentina | Lanus0–1 Patronato2nd Phase - 25 | L |
| Oct 19 | Liga Profesional Argentina | Lanus0–1 Racing Club2nd Phase - 26 | L |
| Oct 26 | Liga Profesional Argentina | Platense 1–1Lanus2nd Phase - 27 | D |
