| August 2022Aug 07 |  Ligue 1 | Rennes 0–1 LorientRegular Season - 1 | W |
| Aug 21 | Ligue 1 | Toulouse 2–2LorientRegular Season - 3 | D |
| Aug 28 | Ligue 1 | Lorient2–1 Clermont FootRegular Season - 4 | W |
| Aug 31 | Ligue 1 | Lens 5–2LorientRegular Season - 5 | L |
| September 2022Sep 04 | Ligue 1 | Ajaccio 0–1LorientRegular Season - 6 | W |
| Sep 07 | Ligue 1 | Lorient3–1 LyonRegular Season - 2 | W |
| Sep 11 | Ligue 1 | Lorient3–2 NantesRegular Season - 7 | W |
| Sep 16 | Ligue 1 | Auxerre 1–3LorientRegular Season - 8 | W |
| October 2022Oct 02 | Ligue 1 | Lorient2–1 LilleRegular Season - 9 | W |
| Oct 09 | Ligue 1 | Stade Brestois 29 1–2LorientRegular Season - 10 | W |
| Oct 15 | Ligue 1 | Lorient0–0 ReimsRegular Season - 11 | D |
| Oct 23 | Ligue 1 | Estac Troyes 2–2LorientRegular Season - 12 | D |
| Oct 30 | Ligue 1 | Lorient1–2 NiceRegular Season - 13 | L |
| November 2022Nov 06 | Ligue 1 | Lorient1–2 Paris Saint GermainRegular Season - 14 | L |
| Nov 13 | Ligue 1 | Strasbourg 1–1LorientRegular Season - 15 | D |
| December 2022Dec 29 | Ligue 1 | Lorient0–2 MontpellierRegular Season - 16 | L |
| January 2023Jan 01 | Ligue 1 | Angers 1–2LorientRegular Season - 17 | W |
| Jan 11 | Ligue 1 | Lorient2–2 MonacoRegular Season - 18 | D |
| Jan 14 | Ligue 1 | Marseille 3–1LorientRegular Season - 19 | L |
| Jan 27 | Ligue 1 | Lorient2–1RennesRegular Season - 20 | W |
| February 2023Feb 01 | Ligue 1 | Reims4–2LorientRegular Season - 21 | L |
| Feb 05 | Ligue 1 | Lorient0–0AngersRegular Season - 22 | D |
| Feb 12 | Ligue 1 | Nantes1–0LorientRegular Season - 23 | L |
| Feb 19 | Ligue 1 | Lorient3–0AjaccioRegular Season - 24 | W |
| Feb 26 | Ligue 1 | Lorient0–1AuxerreRegular Season - 25 | L |
| March 2023Mar 05 | Ligue 1 | Lyon0–0LorientRegular Season - 26 | D |
| Mar 12 | Ligue 1 | Lorient2–0Estac TroyesRegular Season - 27 | W |
| Mar 19 | Ligue 1 | Nice1–1LorientRegular Season - 28 | D |
| April 2023Apr 02 | Ligue 1 | Lille3–1LorientRegular Season - 29 | L |
| Apr 09 | Ligue 1 | Lorient0–0MarseilleRegular Season - 30 | D |
| Apr 16 | Ligue 1 | Monaco3–1LorientRegular Season - 31 | L |
| Apr 23 | Ligue 1 | Lorient0–1ToulouseRegular Season - 32 | L |
| Apr 30 | Ligue 1 | Paris Saint Germain1–3LorientRegular Season - 33 | W |
| May 2023May 07 | Ligue 1 | Lorient2–1Stade Brestois 29Regular Season - 34 | W |
| May 14 | Ligue 1 | Montpellier1–1LorientRegular Season - 35 | D |
| May 21 | Ligue 1 | Lorient1–3LensRegular Season - 36 | L |
| May 27 | Ligue 1 | Clermont Foot2–0LorientRegular Season - 37 | L |
| June 2023Jun 03 | Ligue 1 | Lorient2–1StrasbourgRegular Season - 38 | W |
