| August 2024Aug 11 |  Coppa Italia | Parma 0–1 Palermo1st Round | W |
| Aug 16 |  Serie B | Brescia 1–0PalermoRegular Season - 1 | L |
| Aug 24 | Serie B | Pisa 2–0PalermoRegular Season - 2 | L |
| Aug 27 | Serie B | Cremonese 0–1PalermoRegular Season - 3 | W |
| September 2024Sep 01 | Serie B | Palermo1–1 CosenzaRegular Season - 4 | D |
| Sep 14 | Serie B | Juve Stabia 1–3PalermoRegular Season - 5 | W |
| Sep 21 | Serie B | Palermo0–0 CesenaRegular Season - 6 | D |
| Sep 26 | Coppa Italia | Napoli 5–0Palermo2nd Round | L |
| Sep 30 | Serie B | Sudtirol 1–3PalermoRegular Season - 7 | W |
| October 2024Oct 06 | Serie B | Palermo0–1 SalernitanaRegular Season - 8 | L |
| Oct 19 | Serie B | Modena 2–2PalermoRegular Season - 9 | D |
| Oct 26 | Serie B | Palermo2–0 ReggianaRegular Season - 10 | W |
| Oct 30 | Serie B | Mantova 0–0PalermoRegular Season - 11 | D |
| November 2024Nov 03 | Serie B | Palermo0–1 CittadellaRegular Season - 12 | L |
| Nov 08 | Serie B | Frosinone 1–1PalermoRegular Season - 13 | D |
| Nov 24 | Serie B | Palermo1–1 SampdoriaRegular Season - 14 | D |
| December 2024Dec 01 | Serie B | Palermo2–0 SpeziaRegular Season - 15 | W |
| Dec 07 | Serie B | Carrarese 1–0PalermoRegular Season - 16 | L |
| Dec 15 | Serie B | Palermo1–2 CatanzaroRegular Season - 17 | L |
| Dec 21 | Serie B | Sassuolo 2–1PalermoRegular Season - 18 | L |
| Dec 26 | Serie B | Palermo1–0 BariRegular Season - 19 | W |
| Dec 29 | Serie B | Cittadella2–1PalermoRegular Season - 20 | L |
| January 2025Jan 12 | Serie B | Palermo2–0ModenaRegular Season - 21 | W |
| Jan 19 | Serie B | Palermo1–0Juve StabiaRegular Season - 22 | W |
| Jan 26 | Serie B | Reggiana2–1PalermoRegular Season - 23 | L |
| Jan 31 | Serie B | Palermo1–2PisaRegular Season - 24 | L |
| February 2025Feb 09 | Serie B | Spezia2–2PalermoRegular Season - 25 | D |
| Feb 16 | Serie B | Palermo2–2MantovaRegular Season - 26 | D |
| Feb 23 | Serie B | Cosenza0–3PalermoRegular Season - 27 | W |
| March 2025Mar 02 | Serie B | Palermo1–0BresciaRegular Season - 28 | W |
| Mar 08 | Serie B | Sampdoria1–1PalermoRegular Season - 29 | D |
| Mar 14 | Serie B | Palermo2–3CremoneseRegular Season - 30 | L |
| Mar 30 | Serie B | Salernitana1–2PalermoRegular Season - 31 | W |
| April 2025Apr 06 | Serie B | Palermo5–3SassuoloRegular Season - 32 | W |
| Apr 11 | Serie B | Bari2–1PalermoRegular Season - 33 | L |
| Apr 27 | Serie B | Catanzaro1–3PalermoRegular Season - 35 | W |
| May 2025May 01 | Serie B | Palermo1–2SudtirolRegular Season - 36 | L |
| May 04 | Serie B | Cesena2–1PalermoRegular Season - 37 | L |
| May 09 | Serie B | Palermo2–0FrosinoneRegular Season - 38 | W |
| May 13 | Serie B | Palermo1–1CarrareseRegular Season - 34 | D |
| May 17 | Serie B | Juve Stabia1–0PalermoPromotion Play-offs - Qualifying Round | L |
