| August 2022Aug 05 |  Coppa Italia | Cagliari 3–2 Perugia1st Round | L |
| Aug 13 |  Serie B | Palermo 2–0PerugiaRegular Season - 1 | L |
| Aug 20 | Serie B | Perugia0–0 ParmaRegular Season - 2 | D |
| Aug 28 | Serie B | Perugia1–3 BariRegular Season - 3 | L |
| September 2022Sep 03 | Serie B | Brescia 2–1PerugiaRegular Season - 4 | L |
| Sep 10 | Serie B | Perugia1–0 AscoliRegular Season - 5 | W |
| Sep 18 | Serie B | Ternana 1–0PerugiaRegular Season - 6 | L |
| October 2022Oct 01 | Serie B | Perugia1–3 PisaRegular Season - 7 | L |
| Oct 09 | Serie B | Como 1–0PerugiaRegular Season - 8 | L |
| Oct 16 | Serie B | Perugia1–2 SudtirolRegular Season - 9 | L |
| Oct 22 | Serie B | Reggina 2–3PerugiaRegular Season - 10 | W |
| Oct 30 | Serie B | Perugia0–2 CittadellaRegular Season - 11 | L |
| November 2022Nov 05 | Serie B | Frosinone 1–0PerugiaRegular Season - 12 | L |
| Nov 12 | Serie B | Modena 1–1PerugiaRegular Season - 13 | D |
| Nov 27 | Serie B | Perugia1–0 GenoaRegular Season - 14 | W |
| December 2022Dec 04 | Serie B | Cosenza 0–0PerugiaRegular Season - 15 | D |
| Dec 08 | Serie B | Perugia0–0 SpalRegular Season - 16 | D |
| Dec 11 | Serie B | Cagliari3–2PerugiaRegular Season - 17 | L |
| Dec 19 | Serie B | Perugia2–1 VeneziaRegular Season - 18 | W |
| Dec 26 | Serie B | Benevento 0–2PerugiaRegular Season - 19 | W |
| January 2023Jan 14 | Serie B | Perugia3–3PalermoRegular Season - 20 | D |
| Jan 21 | Serie B | Parma2–0PerugiaRegular Season - 21 | L |
| Jan 28 | Serie B | Bari0–2PerugiaRegular Season - 22 | W |
| February 2023Feb 04 | Serie B | Perugia4–0BresciaRegular Season - 23 | W |
| Feb 11 | Serie B | Ascoli1–0PerugiaRegular Season - 24 | L |
| Feb 18 | Serie B | Perugia3–0TernanaRegular Season - 25 | W |
| Feb 24 | Serie B | Pisa2–1PerugiaRegular Season - 26 | L |
| March 2023Mar 01 | Serie B | Perugia0–0ComoRegular Season - 27 | D |
| Mar 05 | Serie B | Sudtirol2–1PerugiaRegular Season - 28 | L |
| Mar 18 | Serie B | Cittadella0–2PerugiaRegular Season - 30 | W |
| April 2023Apr 01 | Serie B | Perugia1–1FrosinoneRegular Season - 31 | D |
| Apr 05 | Serie B | Perugia1–3RegginaRegular Season - 29 | L |
| Apr 10 | Serie B | Perugia0–1ModenaRegular Season - 32 | L |
| Apr 15 | Serie B | Genoa2–0PerugiaRegular Season - 33 | L |
| Apr 22 | Serie B | Perugia0–0CosenzaRegular Season - 34 | D |
| Apr 30 | Serie B | Spal1–1PerugiaRegular Season - 35 | D |
| May 2023May 05 | Serie B | Perugia0–5CagliariRegular Season - 36 | L |
| May 13 | Serie B | Venezia3–2PerugiaRegular Season - 37 | L |
| May 19 | Serie B | Perugia3–2BeneventoRegular Season - 38 | W |
