| August 2025Aug 09 |  Championship | QPR 1–1 PrestonRegular Season - 1 | D |
| Aug 12 |  EFL Cup | Barrow 0–1Preston1st Round | W |
| Aug 16 | Championship | Preston2–1 LeicesterRegular Season - 2 | W |
| Aug 23 | Championship | Preston1–0 IpswichRegular Season - 3 | W |
| Aug 26 | EFL Cup | Preston2–3 Wrexham2nd Round | L |
| Aug 30 | Championship | Portsmouth 1–0PrestonRegular Season - 4 | L |
| September 2025Sep 13 | Championship | Preston2–2 MiddlesbroughRegular Season - 5 | D |
| Sep 20 | Championship | Derby 0–1PrestonRegular Season - 6 | W |
| Sep 27 | Championship | Preston0–0 Bristol CityRegular Season - 7 | D |
| Sep 30 | Championship | Hull City 2–2PrestonRegular Season - 8 | D |
| October 2025Oct 04 | Championship | Preston2–0 CharltonRegular Season - 9 | W |
| Oct 18 | Championship | West Brom 2–1PrestonRegular Season - 10 | L |
| Oct 21 | Championship | Preston0–1 BirminghamRegular Season - 11 | L |
| Oct 24 | Championship | Preston3–2 Sheffield UtdRegular Season - 12 | W |
| November 2025Nov 01 | Championship | Southampton 0–2PrestonRegular Season - 13 | W |
| Nov 05 | Championship | Preston2–1 SwanseaRegular Season - 14 | W |
| Nov 08 | Championship | Millwall 1–1PrestonRegular Season - 15 | D |
| Nov 21 | Championship | Preston1–2 BlackburnRegular Season - 16 | L |
| Nov 25 | Championship | Watford 1–1PrestonRegular Season - 17 | D |
| Nov 29 | Championship | Sheffield Wednesday 2–3PrestonRegular Season - 18 | W |
| December 2025Dec 06 | Championship | Preston1–1WrexhamRegular Season - 19 | D |
| Dec 09 | Championship | Preston1–1 CoventryRegular Season - 20 | D |
| Dec 13 | Championship | Oxford United 1–2PrestonRegular Season - 21 | W |
| Dec 20 | Championship | Preston1–1 NorwichRegular Season - 22 | D |
| Dec 26 | Championship | Stoke City 0–0PrestonRegular Season - 23 | D |
| Dec 29 | Championship | Wrexham2–1PrestonRegular Season - 24 | L |
| January 2026Jan 01 | Championship | Preston3–0Sheffield WednesdayRegular Season - 25 | W |
| Jan 04 | Championship | Bristol City0–2PrestonRegular Season - 26 | W |
| Jan 09 |  FA Cup | Preston0–1 WiganRound of 64 | L |
| Jan 17 | Championship | Preston0–1DerbyRegular Season - 27 | L |
| Jan 20 | Championship | Preston0–3Hull CityRegular Season - 28 | L |
| Jan 24 | Championship | Middlesbrough4–0PrestonRegular Season - 29 | L |
| Jan 31 | Championship | Ipswich1–1PrestonRegular Season - 30 | D |
| February 2026Feb 07 | Championship | Preston1–0PortsmouthRegular Season - 31 | W |
| Feb 14 | Championship | Preston2–2WatfordRegular Season - 32 | D |
| Feb 20 | Championship | Blackburn1–0PrestonRegular Season - 33 | L |
| Feb 24 | Championship | Swansea1–1PrestonRegular Season - 34 | D |
| Feb 28 | Championship | Preston0–2MillwallRegular Season - 35 | L |
| March 2026Mar 06 | Championship | Preston1–3Oxford UnitedRegular Season - 36 | L |
| Mar 11 | Championship | Coventry3–0PrestonRegular Season - 37 | L |
| Mar 14 | Championship | Norwich2–0PrestonRegular Season - 38 | L |
| Mar 20 | Championship | Preston3–1Stoke CityRegular Season - 39 | W |
| April 2026Apr 03 | Championship | Leicester2–2PrestonRegular Season - 40 | D |
| Apr 06 | Championship | Preston1–1QPRRegular Season - 41 | D |
| Apr 11 | Championship | Charlton1–2PrestonRegular Season - 42 | W |
| Apr 18 | Championship | Preston0–2West BromRegular Season - 43 | L |
| Apr 22 | Championship | Birmingham2–1PrestonRegular Season - 44 | L |
| Apr 25 | Championship | Sheffield Utd2–3PrestonRegular Season - 45 | W |
| May 2026May 02 | Championship | Preston1–3SouthamptonRegular Season - 46 | L |
