| agost del 202629 d’ag. |  Bundesliga | 1. FC Köln 15:30 1899 HoffenheimRegular Season - 1 | — |
| setembre del 202605 de set. | Bundesliga | 1899 Hoffenheim15:30 Borussia DortmundRegular Season - 2 | — |
| 12 de set. | Bundesliga | 1899 Hoffenheim15:30 VfB StuttgartRegular Season - 3 | — |
| 20 de set. | Bundesliga | SC Paderborn 07 19:301899 HoffenheimRegular Season - 4 | — |
| octubre del 202610 d’oct. | Bundesliga | 1899 Hoffenheim15:30 Hamburger SVRegular Season - 5 | — |
| 17 d’oct. | Bundesliga | Borussia Mönchengladbach 15:301899 HoffenheimRegular Season - 6 | — |
| 24 d’oct. | Bundesliga | 1899 Hoffenheim15:30 Bayer LeverkusenRegular Season - 7 | — |
| 31 d’oct. | Bundesliga | Werder Bremen 15:301899 HoffenheimRegular Season - 8 | — |
| novembre del 202607 de nov. | Bundesliga | 1899 Hoffenheim15:30 FC Schalke 04Regular Season - 9 | — |
| 21 de nov. | Bundesliga | Eintracht Frankfurt 15:301899 HoffenheimRegular Season - 10 | — |
| 28 de nov. | Bundesliga | 1899 Hoffenheim15:30 FC AugsburgRegular Season - 11 | — |
| desembre del 202605 de des. | Bundesliga | SC Freiburg 15:301899 HoffenheimRegular Season - 12 | — |
| 12 de des. | Bundesliga | 1899 Hoffenheim15:30 Bayern MünchenRegular Season - 13 | — |
| 19 de des. | Bundesliga | Union Berlin 15:301899 HoffenheimRegular Season - 14 | — |
| gener del 202709 de gen. | Bundesliga | 1899 Hoffenheim15:30 SV ElversbergRegular Season - 15 | — |
| 13 de gen. | Bundesliga | FSV Mainz 05 20:301899 HoffenheimRegular Season - 16 | — |
| 16 de gen. | Bundesliga | 1899 Hoffenheim15:30 RB LeipzigRegular Season - 17 | — |
| 23 de gen. | Bundesliga | 1899 Hoffenheim15:301. FC KölnRegular Season - 18 | — |
| 30 de gen. | Bundesliga | Borussia Dortmund15:301899 HoffenheimRegular Season - 19 | — |
| febrer del 202706 de febr. | Bundesliga | VfB Stuttgart15:301899 HoffenheimRegular Season - 20 | — |
| 13 de febr. | Bundesliga | 1899 Hoffenheim15:30SC Paderborn 07Regular Season - 21 | — |
| 20 de febr. | Bundesliga | Hamburger SV15:301899 HoffenheimRegular Season - 22 | — |
| 27 de febr. | Bundesliga | 1899 Hoffenheim15:30Borussia MönchengladbachRegular Season - 23 | — |
| març del 202703 de març | Bundesliga | Bayer Leverkusen20:301899 HoffenheimRegular Season - 24 | — |
| 06 de març | Bundesliga | 1899 Hoffenheim15:30Werder BremenRegular Season - 25 | — |
| 13 de març | Bundesliga | FC Schalke 0415:301899 HoffenheimRegular Season - 26 | — |
| 20 de març | Bundesliga | 1899 Hoffenheim15:30Eintracht FrankfurtRegular Season - 27 | — |
| abril del 202703 d’abr. | Bundesliga | FC Augsburg15:301899 HoffenheimRegular Season - 28 | — |
| 10 d’abr. | Bundesliga | 1899 Hoffenheim15:30SC FreiburgRegular Season - 29 | — |
| 17 d’abr. | Bundesliga | Bayern München15:301899 HoffenheimRegular Season - 30 | — |
| 24 d’abr. | Bundesliga | 1899 Hoffenheim15:30Union BerlinRegular Season - 31 | — |
| maig del 202708 de maig | Bundesliga | SV Elversberg15:301899 HoffenheimRegular Season - 32 | — |
| 15 de maig | Bundesliga | 1899 Hoffenheim15:30FSV Mainz 05Regular Season - 33 | — |
| 22 de maig | Bundesliga | RB Leipzig15:301899 HoffenheimRegular Season - 34 | — |
