| agost del 202108 d’ag. |  Ligue 1 | Nice 0–0 ReimsRegular Season - 1 | E |
| 14 d’ag. | Ligue 1 | Lille 0–4NiceRegular Season - 2 | V |
| 28 d’ag. | Ligue 1 | Nice4–0 BordeauxRegular Season - 4 | V |
| setembre del 202112 de set. | Ligue 1 | Nantes 0–2NiceRegular Season - 5 | V |
| 19 de set. | Ligue 1 | Nice2–2 MonacoRegular Season - 6 | E |
| 22 de set. | Ligue 1 | Lorient 1–0NiceRegular Season - 7 | D |
| 25 de set. | Ligue 1 | Saint Etienne 0–3NiceRegular Season - 8 | V |
| octubre del 202102 d’oct. | Ligue 1 | Nice2–1 Stade Brestois 29Regular Season - 9 | V |
| 17 d’oct. | Ligue 1 | Estac Troyes 1–0NiceRegular Season - 10 | D |
| 24 d’oct. | Ligue 1 | Nice3–2 LyonRegular Season - 11 | V |
| 27 d’oct. | Ligue 1 | Nice1–1 MarseilleRegular Season - 3 | E |
| 31 d’oct. | Ligue 1 | Angers 1–2NiceRegular Season - 12 | V |
| novembre del 202107 de nov. | Ligue 1 | Nice0–1 MontpellierRegular Season - 13 | D |
| 21 de nov. | Ligue 1 | Clermont Foot 1–2NiceRegular Season - 14 | V |
| 27 de nov. | Ligue 1 | Nice0–1 MetzRegular Season - 15 | D |
| desembre del 202101 de des. | Ligue 1 | Paris Saint Germain 0–0NiceRegular Season - 16 | E |
| 05 de des. | Ligue 1 | Nice0–3 StrasbourgRegular Season - 17 | D |
| 12 de des. | Ligue 1 | Rennes 1–2NiceRegular Season - 18 | V |
| 22 de des. | Ligue 1 | Nice2–1 LensRegular Season - 19 | V |
| gener del 202209 de gen. | Ligue 1 | Stade Brestois 290–3NiceRegular Season - 20 | V |
| 14 de gen. | Ligue 1 | Nice2–1NantesRegular Season - 21 | V |
| 23 de gen. | Ligue 1 | Metz0–2NiceRegular Season - 22 | V |
| febrer del 202206 de febr. | Ligue 1 | Nice0–1Clermont FootRegular Season - 23 | D |
| 12 de febr. | Ligue 1 | Lyon2–0NiceRegular Season - 24 | D |
| 20 de febr. | Ligue 1 | Nice1–0AngersRegular Season - 25 | V |
| 26 de febr. | Ligue 1 | Strasbourg0–0NiceRegular Season - 26 | E |
| març del 202205 de març | Ligue 1 | Nice1–0Paris Saint GermainRegular Season - 27 | V |
| 12 de març | Ligue 1 | Montpellier0–0NiceRegular Season - 28 | E |
| 20 de març | Ligue 1 | Marseille2–1NiceRegular Season - 29 | D |
| abril del 202202 d’abr. | Ligue 1 | Nice1–1RennesRegular Season - 30 | E |
| 10 d’abr. | Ligue 1 | Lens3–0NiceRegular Season - 31 | D |
| 17 d’abr. | Ligue 1 | Nice2–1LorientRegular Season - 32 | V |
| 20 d’abr. | Ligue 1 | Monaco1–0NiceRegular Season - 33 | D |
| 24 d’abr. | Ligue 1 | Nice1–0Estac TroyesRegular Season - 34 | V |
| maig del 202201 de maig | Ligue 1 | Bordeaux0–1NiceRegular Season - 35 | V |
| 11 de maig | Ligue 1 | Nice4–2Saint EtienneRegular Season - 36 | V |
| 14 de maig | Ligue 1 | Nice1–3LilleRegular Season - 37 | D |
| 21 de maig | Ligue 1 | Reims2–3NiceRegular Season - 38 | V |
