| August 2021Aug 08 |  Ligue 1 | Nice 0–0 ReimsRegular Season - 1 | D |
| Aug 14 | Ligue 1 | Lille 0–4NiceRegular Season - 2 | W |
| Aug 28 | Ligue 1 | Nice4–0 BordeauxRegular Season - 4 | W |
| September 2021Sep 12 | Ligue 1 | Nantes 0–2NiceRegular Season - 5 | W |
| Sep 19 | Ligue 1 | Nice2–2 MonacoRegular Season - 6 | D |
| Sep 22 | Ligue 1 | Lorient 1–0NiceRegular Season - 7 | L |
| Sep 25 | Ligue 1 | Saint Etienne 0–3NiceRegular Season - 8 | W |
| October 2021Oct 02 | Ligue 1 | Nice2–1 Stade Brestois 29Regular Season - 9 | W |
| Oct 17 | Ligue 1 | Estac Troyes 1–0NiceRegular Season - 10 | L |
| Oct 24 | Ligue 1 | Nice3–2 LyonRegular Season - 11 | W |
| Oct 27 | Ligue 1 | Nice1–1 MarseilleRegular Season - 3 | D |
| Oct 31 | Ligue 1 | Angers 1–2NiceRegular Season - 12 | W |
| November 2021Nov 07 | Ligue 1 | Nice0–1 MontpellierRegular Season - 13 | L |
| Nov 21 | Ligue 1 | Clermont Foot 1–2NiceRegular Season - 14 | W |
| Nov 27 | Ligue 1 | Nice0–1 MetzRegular Season - 15 | L |
| December 2021Dec 01 | Ligue 1 | Paris Saint Germain 0–0NiceRegular Season - 16 | D |
| Dec 05 | Ligue 1 | Nice0–3 StrasbourgRegular Season - 17 | L |
| Dec 12 | Ligue 1 | Rennes 1–2NiceRegular Season - 18 | W |
| Dec 22 | Ligue 1 | Nice2–1 LensRegular Season - 19 | W |
| January 2022Jan 09 | Ligue 1 | Stade Brestois 290–3NiceRegular Season - 20 | W |
| Jan 14 | Ligue 1 | Nice2–1NantesRegular Season - 21 | W |
| Jan 23 | Ligue 1 | Metz0–2NiceRegular Season - 22 | W |
| February 2022Feb 06 | Ligue 1 | Nice0–1Clermont FootRegular Season - 23 | L |
| Feb 12 | Ligue 1 | Lyon2–0NiceRegular Season - 24 | L |
| Feb 20 | Ligue 1 | Nice1–0AngersRegular Season - 25 | W |
| Feb 26 | Ligue 1 | Strasbourg0–0NiceRegular Season - 26 | D |
| March 2022Mar 05 | Ligue 1 | Nice1–0Paris Saint GermainRegular Season - 27 | W |
| Mar 12 | Ligue 1 | Montpellier0–0NiceRegular Season - 28 | D |
| Mar 20 | Ligue 1 | Marseille2–1NiceRegular Season - 29 | L |
| April 2022Apr 02 | Ligue 1 | Nice1–1RennesRegular Season - 30 | D |
| Apr 10 | Ligue 1 | Lens3–0NiceRegular Season - 31 | L |
| Apr 17 | Ligue 1 | Nice2–1LorientRegular Season - 32 | W |
| Apr 20 | Ligue 1 | Monaco1–0NiceRegular Season - 33 | L |
| Apr 24 | Ligue 1 | Nice1–0Estac TroyesRegular Season - 34 | W |
| May 2022May 01 | Ligue 1 | Bordeaux0–1NiceRegular Season - 35 | W |
| May 11 | Ligue 1 | Nice4–2Saint EtienneRegular Season - 36 | W |
| May 14 | Ligue 1 | Nice1–3LilleRegular Season - 37 | L |
| May 21 | Ligue 1 | Reims2–3NiceRegular Season - 38 | W |
