| August 2020Aug 23 |  Ligue 1 | Nice 2–1 LensRegular Season - 1 | W |
| Aug 29 | Ligue 1 | Strasbourg 0–2NiceRegular Season - 2 | W |
| September 2020Sep 12 | Ligue 1 | Montpellier 3–1NiceRegular Season - 3 | L |
| Sep 20 | Ligue 1 | Nice0–3 Paris Saint GermainRegular Season - 4 | L |
| Sep 27 | Ligue 1 | Bordeaux 0–0NiceRegular Season - 5 | D |
| October 2020Oct 03 | Ligue 1 | Nice2–1 NantesRegular Season - 6 | W |
| Oct 18 | Ligue 1 | Saint Etienne 1–3NiceRegular Season - 7 | W |
| Oct 22 |  Europa League | Bayer Leverkusen 6–2NiceGroup C - 1 | L |
| Oct 25 | Ligue 1 | Nice1–1 LilleRegular Season - 8 | D |
| Oct 29 | Europa League | Nice1–0 Hapoel Beer ShevaGroup C - 2 | W |
| November 2020Nov 01 | Ligue 1 | Angers 0–3NiceRegular Season - 9 | W |
| Nov 05 | Europa League | Slavia Praha 3–2NiceGroup C - 3 | L |
| Nov 08 | Ligue 1 | Nice1–2 MonacoRegular Season - 10 | L |
| Nov 26 | Europa League | Nice1–3Slavia PrahaGroup C - 4 | L |
| Nov 29 | Ligue 1 | Nice1–3 DijonRegular Season - 12 | L |
| December 2020Dec 03 | Europa League | Nice2–3Bayer LeverkusenGroup C - 5 | L |
| Dec 06 | Ligue 1 | Reims 0–0NiceRegular Season - 13 | D |
| Dec 10 | Europa League | Hapoel Beer Sheva1–0NiceGroup C - 6 | L |
| Dec 13 | Ligue 1 | Nice0–1 RennesRegular Season - 14 | L |
| Dec 16 | Ligue 1 | Nimes 0–2NiceRegular Season - 15 | W |
| Dec 19 | Ligue 1 | Nice1–4 LyonRegular Season - 16 | L |
| Dec 23 | Ligue 1 | Nice2–2 LorientRegular Season - 17 | D |
| January 2021Jan 06 | Ligue 1 | Stade Brestois 29 2–0NiceRegular Season - 18 | L |
| Jan 09 | Ligue 1 | Metz 1–1NiceRegular Season - 19 | D |
| Jan 17 | Ligue 1 | Nice0–3BordeauxRegular Season - 20 | L |
| Jan 23 | Ligue 1 | Lens0–1NiceRegular Season - 21 | W |
| Jan 31 | Ligue 1 | Nice0–1Saint EtienneRegular Season - 22 | L |
| February 2021Feb 03 | Ligue 1 | Monaco2–1NiceRegular Season - 23 | L |
| Feb 07 | Ligue 1 | Nice3–0AngersRegular Season - 24 | W |
| Feb 13 | Ligue 1 | Paris Saint Germain2–1NiceRegular Season - 25 | L |
| Feb 17 | Ligue 1 | Marseille 3–2NiceRegular Season - 11 | L |
| Feb 21 | Ligue 1 | Nice1–2MetzRegular Season - 26 | L |
| Feb 26 | Ligue 1 | Rennes1–2NiceRegular Season - 27 | W |
| March 2021Mar 03 | Ligue 1 | Nice2–1NimesRegular Season - 28 | W |
| Mar 14 | Ligue 1 | Lorient1–1NiceRegular Season - 29 | D |
| Mar 20 | Ligue 1 | Nice3–0MarseilleRegular Season - 30 | W |
| April 2021Apr 04 | Ligue 1 | Nantes1–2NiceRegular Season - 31 | W |
| Apr 11 | Ligue 1 | Nice0–0ReimsRegular Season - 32 | D |
| Apr 18 | Ligue 1 | Dijon2–0NiceRegular Season - 33 | L |
| Apr 25 | Ligue 1 | Nice3–1MontpellierRegular Season - 34 | W |
| May 2021May 01 | Ligue 1 | Lille2–0NiceRegular Season - 35 | L |
| May 09 | Ligue 1 | Nice3–2Stade Brestois 29Regular Season - 36 | W |
| May 16 | Ligue 1 | Nice0–2StrasbourgRegular Season - 37 | L |
| May 23 | Ligue 1 | Lyon2–3NiceRegular Season - 38 | W |
