| August 2020Aug 22 |  Ligue 1 | Dijon 0–1 AngersRegular Season - 1 | W |
| Aug 30 | Ligue 1 | Angers0–2 BordeauxRegular Season - 2 | L |
| September 2020Sep 13 | Ligue 1 | Angers1–0 ReimsRegular Season - 3 | W |
| Sep 20 | Ligue 1 | Montpellier 4–1AngersRegular Season - 4 | L |
| Sep 27 | Ligue 1 | Angers3–2 Stade Brestois 29Regular Season - 5 | W |
| October 2020Oct 02 | Ligue 1 | Paris Saint Germain 6–1AngersRegular Season - 6 | L |
| Oct 18 | Ligue 1 | Angers1–1 MetzRegular Season - 7 | D |
| Oct 23 | Ligue 1 | Rennes 1–2AngersRegular Season - 8 | W |
| November 2020Nov 01 | Ligue 1 | Angers0–3 NiceRegular Season - 9 | L |
| Nov 08 | Ligue 1 | Nimes 1–5AngersRegular Season - 10 | W |
| Nov 22 | Ligue 1 | Angers0–1 LyonRegular Season - 11 | L |
| Nov 29 | Ligue 1 | Lens 1–3AngersRegular Season - 12 | W |
| December 2020Dec 06 | Ligue 1 | Angers2–0 LorientRegular Season - 13 | W |
| Dec 11 | Ligue 1 | Saint Etienne 0–0AngersRegular Season - 14 | D |
| Dec 16 | Ligue 1 | Angers0–2 StrasbourgRegular Season - 15 | L |
| Dec 20 | Ligue 1 | Nantes 1–1AngersRegular Season - 16 | D |
| Dec 23 | Ligue 1 | Angers2–1 MarseilleRegular Season - 17 | W |
| January 2021Jan 06 | Ligue 1 | Lille 1–2AngersRegular Season - 18 | W |
| Jan 09 | Ligue 1 | Monaco 3–0AngersRegular Season - 19 | L |
| Jan 16 | Ligue 1 | Angers0–1Paris Saint GermainRegular Season - 20 | L |
| Jan 24 | Ligue 1 | Bordeaux2–1AngersRegular Season - 21 | L |
| Jan 31 | Ligue 1 | Angers3–1NimesRegular Season - 22 | W |
| February 2021Feb 03 | Ligue 1 | Reims0–0AngersRegular Season - 23 | D |
| Feb 07 | Ligue 1 | Nice3–0AngersRegular Season - 24 | L |
| Feb 14 | Ligue 1 | Angers1–3NantesRegular Season - 25 | L |
| Feb 21 | Ligue 1 | Strasbourg0–0AngersRegular Season - 26 | D |
| Feb 28 | Ligue 1 | Angers2–2LensRegular Season - 27 | D |
| March 2021Mar 03 | Ligue 1 | Metz0–1AngersRegular Season - 28 | W |
| Mar 13 | Ligue 1 | Angers0–1Saint EtienneRegular Season - 29 | L |
| Mar 21 | Ligue 1 | Stade Brestois 290–0AngersRegular Season - 30 | D |
| April 2021Apr 04 | Ligue 1 | Angers1–1MontpellierRegular Season - 31 | D |
| Apr 11 | Ligue 1 | Lyon3–0AngersRegular Season - 32 | L |
| Apr 17 | Ligue 1 | Angers0–3RennesRegular Season - 33 | L |
| Apr 25 | Ligue 1 | Angers0–1MonacoRegular Season - 34 | L |
| May 2021May 02 | Ligue 1 | Lorient2–0AngersRegular Season - 35 | L |
| May 09 | Ligue 1 | Angers3–0DijonRegular Season - 36 | W |
| May 16 | Ligue 1 | Marseille3–2AngersRegular Season - 37 | L |
| May 23 | Ligue 1 | Angers1–2LilleRegular Season - 38 | L |
