| August 2024Aug 17 |  Serie A | Empoli 0–0 MonzaRegular Season - 1 | D |
| Aug 25 | Serie A | AS Roma 1–2EmpoliRegular Season - 2 | W |
| Aug 31 | Serie A | Bologna 1–1EmpoliRegular Season - 3 | D |
| September 2024Sep 14 | Serie A | Empoli0–0 JuventusRegular Season - 4 | D |
| Sep 20 | Serie A | Cagliari 0–2EmpoliRegular Season - 5 | W |
| Sep 29 | Serie A | Empoli0–0 FiorentinaRegular Season - 6 | D |
| October 2024Oct 06 | Serie A | Lazio 2–1EmpoliRegular Season - 7 | L |
| Oct 20 | Serie A | Empoli0–1 NapoliRegular Season - 8 | L |
| Oct 27 | Serie A | Parma 1–1EmpoliRegular Season - 9 | D |
| Oct 30 | Serie A | Empoli0–3 InterRegular Season - 10 | L |
| November 2024Nov 04 | Serie A | Empoli1–0 ComoRegular Season - 11 | W |
| Nov 08 | Serie A | Lecce 1–1EmpoliRegular Season - 12 | D |
| Nov 25 | Serie A | Empoli1–1 UdineseRegular Season - 13 | D |
| Nov 30 | Serie A | AC Milan 3–0EmpoliRegular Season - 14 | L |
| December 2024Dec 08 | Serie A | Hellas Verona 1–4EmpoliRegular Season - 15 | W |
| Dec 13 | Serie A | Empoli0–1 TorinoRegular Season - 16 | L |
| Dec 22 | Serie A | Atalanta 3–2EmpoliRegular Season - 17 | L |
| Dec 28 | Serie A | Empoli1–2 GenoaRegular Season - 18 | L |
| January 2025Jan 04 | Serie A | Venezia 1–1EmpoliRegular Season - 19 | D |
| Jan 11 | Serie A | Empoli1–3LecceRegular Season - 20 | L |
| Jan 19 | Serie A | Inter3–1EmpoliRegular Season - 21 | L |
| Jan 25 | Serie A | Empoli1–1BolognaRegular Season - 22 | D |
| February 2025Feb 02 | Serie A | Juventus4–1EmpoliRegular Season - 23 | L |
| Feb 08 | Serie A | Empoli0–2AC MilanRegular Season - 24 | L |
| Feb 16 | Serie A | Udinese3–0EmpoliRegular Season - 25 | L |
| Feb 23 | Serie A | Empoli0–5AtalantaRegular Season - 26 | L |
| March 2025Mar 02 | Serie A | Genoa1–1EmpoliRegular Season - 27 | D |
| Mar 09 | Serie A | Empoli0–1AS RomaRegular Season - 28 | L |
| Mar 15 | Serie A | Torino1–0EmpoliRegular Season - 29 | L |
| Mar 29 | Serie A | Como1–1EmpoliRegular Season - 30 | D |
| April 2025Apr 06 | Serie A | Empoli0–0CagliariRegular Season - 31 | D |
| Apr 14 | Serie A | Napoli3–0EmpoliRegular Season - 32 | L |
| Apr 20 | Serie A | Empoli2–2VeneziaRegular Season - 33 | D |
| Apr 27 | Serie A | Fiorentina2–1EmpoliRegular Season - 34 | L |
| May 2025May 04 | Serie A | Empoli0–1LazioRegular Season - 35 | L |
| May 10 | Serie A | Empoli2–1ParmaRegular Season - 36 | W |
| May 18 | Serie A | Monza1–3EmpoliRegular Season - 37 | W |
| May 25 | Serie A | Empoli1–2Hellas VeronaRegular Season - 38 | L |
