| February 2022Feb 13 |  Liga Profesional Argentina | Estudiantes L.P. 2–1 Independiente1st Phase - 1 | L |
| Feb 15 | Liga Profesional Argentina | Independiente1–0 Arsenal Sarandi1st Phase - 2 | W |
| Feb 20 | Liga Profesional Argentina | Velez Sarsfield 0–0Independiente1st Phase - 3 | D |
| Feb 27 | Liga Profesional Argentina | Independiente2–2 Boca Juniors1st Phase - 4 | D |
| March 2022Mar 07 | Liga Profesional Argentina | Godoy Cruz 3–3Independiente1st Phase - 5 | D |
| Mar 15 | Liga Profesional Argentina | Independiente1–1 Central Cordoba de Santiago1st Phase - 6 | D |
| Mar 20 | Liga Profesional Argentina | Independiente1–2 Racing Club1st Phase - 7 | L |
| Mar 26 |  Copa Argentina | Independiente1–1 Central Norte1st Round | D |
| April 2022Apr 02 | Liga Profesional Argentina | Barracas Central 0–1Independiente1st Phase - 8 | W |
| Apr 06 |  Copa Sudamericana | Ceara 2–1IndependienteGroup Stage - 1 | L |
| Apr 10 | Liga Profesional Argentina | Independiente1–1 Tigre1st Phase - 9 | D |
| Apr 13 | Copa Sudamericana | Independiente2–0 General CaballeroGroup Stage - 2 | W |
| Apr 16 | Liga Profesional Argentina | Colon Santa Fe 2–2Independiente1st Phase - 10 | D |
| Apr 20 | Liga Profesional Argentina | Independiente1–1 Aldosivi1st Phase - 11 | D |
| Apr 23 | Liga Profesional Argentina | Rosario Central 3–0Independiente1st Phase - 12 | L |
| Apr 27 | Copa Sudamericana | Deportivo La Guaira 0–2IndependienteGroup Stage - 3 | W |
| May 2022May 01 | Liga Profesional Argentina | Lanus 1–0Independiente1st Phase - 13 | L |
| May 04 | Copa Sudamericana | General Caballero0–4IndependienteGroup Stage - 4 | W |
| May 07 | Liga Profesional Argentina | Independiente3–0 Huracan1st Phase - 14 | W |
| May 20 | Copa Sudamericana | Independiente4–0Deportivo La GuairaGroup Stage - 5 | W |
| May 26 | Copa Sudamericana | Independiente0–2CearaGroup Stage - 6 | L |
| June 2022Jun 04 | Liga Profesional Argentina | San Lorenzo 1–1Independiente2nd Phase - 1 | D |
| Jun 11 | Liga Profesional Argentina | Independiente1–0 Talleres Cordoba2nd Phase - 2 | W |
| Jun 17 | Liga Profesional Argentina | Argentinos JRS 2–1Independiente2nd Phase - 3 | L |
| Jun 21 | Liga Profesional Argentina | Independiente2–1Estudiantes L.P.2nd Phase - 4 | W |
| Jun 24 | Copa Argentina | Atletico Tucuman 0–1IndependienteRound of 32 | W |
| Jun 27 | Liga Profesional Argentina | Patronato 3–1Independiente2nd Phase - 5 | L |
| July 2022Jul 05 | Liga Profesional Argentina | Independiente1–3 Platense2nd Phase - 6 | L |
| Jul 10 | Liga Profesional Argentina | Racing Club1–0Independiente2nd Phase - 7 | L |
| Jul 16 | Liga Profesional Argentina | Independiente0–0Rosario Central2nd Phase - 8 | D |
| Jul 21 | Liga Profesional Argentina | Defensa Y Justicia 2–1Independiente2nd Phase - 9 | L |
| Jul 24 | Liga Profesional Argentina | Independiente0–1Atletico Tucuman2nd Phase - 10 | L |
| August 2022Aug 02 | Liga Profesional Argentina | Colon Santa Fe0–3Independiente2nd Phase - 11 | W |
| Aug 07 | Liga Profesional Argentina | Independiente0–1 River Plate2nd Phase - 12 | L |
| Aug 13 | Liga Profesional Argentina | Lanus1–1Independiente2nd Phase - 13 | D |
| Aug 17 | Liga Profesional Argentina | Independiente1–1Huracan2nd Phase - 14 | D |
| Aug 21 | Liga Profesional Argentina | Godoy Cruz1–1Independiente2nd Phase - 15 | D |
| Aug 28 | Liga Profesional Argentina | Independiente1–1Velez Sarsfield2nd Phase - 16 | D |
| September 2022Sep 04 | Liga Profesional Argentina | Gimnasia L.P. 3–1Independiente2nd Phase - 17 | L |
| Sep 08 | Liga Profesional Argentina | Independiente3–0Aldosivi2nd Phase - 18 | W |
| Sep 12 | Liga Profesional Argentina | Sarmiento Junin 1–2Independiente2nd Phase - 19 | W |
| Sep 16 | Copa Argentina | Velez Sarsfield0–2IndependienteRound of 16 | W |
| Sep 20 | Liga Profesional Argentina | Union Santa Fe 0–1Independiente2nd Phase - 20 | W |
| Sep 25 | Liga Profesional Argentina | Independiente1–0 Newells Old Boys2nd Phase - 21 | W |
| Sep 28 | Copa Argentina | Independiente0–0Talleres CordobaQuarter-finals | D |
| October 2022Oct 02 | Liga Profesional Argentina | Arsenal Sarandi0–1Independiente2nd Phase - 22 | W |
| Oct 06 | Liga Profesional Argentina | Independiente1–2Central Cordoba de Santiago2nd Phase - 23 | L |
| Oct 09 | Liga Profesional Argentina | Tigre2–1Independiente2nd Phase - 24 | L |
| Oct 13 | Liga Profesional Argentina | Independiente2–2Barracas Central2nd Phase - 25 | D |
| Oct 16 | Liga Profesional Argentina | Independiente1–0 Banfield2nd Phase - 26 | W |
| Oct 23 | Liga Profesional Argentina | Boca Juniors2–2Independiente2nd Phase - 27 | D |
