| January 2023Jan 27 |  Liga Profesional Argentina | Talleres Cordoba 0–1 IndependienteRound - 1 | W |
| February 2023Feb 05 | Liga Profesional Argentina | Independiente1–2 PlatenseRound - 2 | L |
| Feb 12 | Liga Profesional Argentina | Velez Sarsfield 0–0IndependienteRound - 3 | D |
| Feb 20 | Liga Profesional Argentina | Independiente0–2 Defensa Y JusticiaRound - 4 | L |
| Feb 27 | Liga Profesional Argentina | Banfield 0–0IndependienteRound - 5 | D |
| March 2023Mar 05 | Liga Profesional Argentina | Independiente2–2 Instituto CordobaRound - 6 | D |
| Mar 10 | Liga Profesional Argentina | Barracas Central 1–1IndependienteRound - 7 | D |
| Mar 18 | Liga Profesional Argentina | Independiente2–2 Colon Santa FeRound - 8 | D |
| Mar 26 |  Copa Argentina | Independiente3–0 Ciudad de Bolívar1st Round | W |
| April 2023Apr 02 | Liga Profesional Argentina | San Lorenzo 0–0IndependienteRound - 9 | D |
| Apr 09 | Liga Profesional Argentina | Independiente1–2 Estudiantes L.P.Round - 10 | L |
| Apr 13 | Liga Profesional Argentina | Rosario Central 1–0IndependienteRound - 11 | L |
| Apr 16 | Liga Profesional Argentina | Independiente1–1 Racing ClubRound - 12 | D |
| Apr 24 | Liga Profesional Argentina | River Plate 2–0IndependienteRound - 13 | L |
| Apr 30 | Liga Profesional Argentina | Independiente2–0 Belgrano CordobaRound - 14 | W |
| May 2023May 07 | Liga Profesional Argentina | Argentinos JRS 2–2IndependienteRound - 15 | D |
| May 13 | Liga Profesional Argentina | Independiente2–1 TigreRound - 16 | W |
| May 19 | Liga Profesional Argentina | Arsenal Sarandi 2–1IndependienteRound - 17 | L |
| May 28 | Liga Profesional Argentina | Independiente1–1 LanusRound - 18 | D |
| June 2023Jun 04 | Liga Profesional Argentina | Godoy Cruz 2–1IndependienteRound - 19 | L |
| Jun 10 | Liga Profesional Argentina | Independiente2–0 Sarmiento JuninRound - 20 | W |
| Jun 24 | Liga Profesional Argentina | Union Santa Fe 3–0IndependienteRound - 21 | L |
| July 2023Jul 02 | Liga Profesional Argentina | Independiente1–0 HuracanRound - 22 | W |
| Jul 08 | Liga Profesional Argentina | Gimnasia L.P. 1–1IndependienteRound - 23 | D |
| Jul 12 | Liga Profesional Argentina | Independiente0–2 Newells Old BoysRound - 24 | L |
| Jul 17 | Liga Profesional Argentina | Central Cordoba de Santiago 0–1IndependienteRound - 25 | W |
| Jul 23 | Liga Profesional Argentina | Atletico Tucuman 1–0IndependienteRound - 26 | L |
| Jul 29 | Liga Profesional Argentina | Independiente0–2 Boca JuniorsRound - 27 | L |
| August 2023Aug 16 | Copa Argentina | Independiente0–0Central Cordoba de SantiagoRound of 32 | D |
| September 2023Sep 09 | Copa Argentina | Independiente1–1Estudiantes L.P.Round of 16 | D |
