| August 2024Aug 18 |  Serie A | Lazio 3–1 VeneziaRegular Season - 1 | W |
| Aug 24 | Serie A | Udinese 2–1LazioRegular Season - 2 | L |
| Aug 31 | Serie A | Lazio2–2 AC MilanRegular Season - 3 | D |
| September 2024Sep 16 | Serie A | Lazio2–1 Hellas VeronaRegular Season - 4 | W |
| Sep 22 | Serie A | Fiorentina 2–1LazioRegular Season - 5 | L |
| Sep 25 |  Europa League | Dynamo Kyiv 0–3LazioLeague Stage - 1 | W |
| Sep 29 | Serie A | Torino 2–3LazioRegular Season - 6 | W |
| October 2024Oct 03 | Europa League | Lazio4–1 NiceLeague Stage - 2 | W |
| Oct 06 | Serie A | Lazio2–1 EmpoliRegular Season - 7 | W |
| Oct 19 | Serie A | Juventus 1–0LazioRegular Season - 8 | L |
| Oct 24 | Europa League | Twente 0–2LazioLeague Stage - 3 | W |
| Oct 27 | Serie A | Lazio3–0 GenoaRegular Season - 9 | W |
| Oct 31 | Serie A | Como 1–5LazioRegular Season - 10 | W |
| November 2024Nov 04 | Serie A | Lazio2–1 CagliariRegular Season - 11 | W |
| Nov 07 | Europa League | Lazio2–1 FC PortoLeague Stage - 4 | W |
| Nov 10 | Serie A | Monza 0–1LazioRegular Season - 12 | W |
| Nov 24 | Serie A | Lazio3–0 BolognaRegular Season - 13 | W |
| Nov 28 | Europa League | Lazio0–0 LudogoretsLeague Stage - 5 | D |
| December 2024Dec 01 | Serie A | Parma 3–1LazioRegular Season - 14 | L |
| Dec 08 | Serie A | Napoli 0–1LazioRegular Season - 15 | W |
| Dec 12 | Europa League | Ajax 1–3LazioLeague Stage - 6 | W |
| Dec 16 | Serie A | Lazio0–6 InterRegular Season - 16 | L |
| Dec 21 | Serie A | Lecce 1–2LazioRegular Season - 17 | W |
| Dec 28 | Serie A | Lazio1–1 AtalantaRegular Season - 18 | D |
| January 2025Jan 05 | Serie A | AS Roma 2–0LazioRegular Season - 19 | L |
| Jan 10 | Serie A | Lazio1–1ComoRegular Season - 20 | D |
| Jan 19 | Serie A | Hellas Verona0–3LazioRegular Season - 21 | W |
| Jan 23 | Europa League | Lazio3–1 Real SociedadLeague Stage - 7 | W |
| Jan 26 | Serie A | Lazio1–2FiorentinaRegular Season - 22 | L |
| Jan 30 | Europa League | SC Braga 1–0LazioLeague Stage - 8 | L |
| February 2025Feb 03 | Serie A | Cagliari1–2LazioRegular Season - 23 | W |
| Feb 09 | Serie A | Lazio5–1MonzaRegular Season - 24 | W |
| Feb 15 | Serie A | Lazio2–2NapoliRegular Season - 25 | D |
| Feb 22 | Serie A | Venezia0–0LazioRegular Season - 26 | D |
| March 2025Mar 02 | Serie A | AC Milan1–2LazioRegular Season - 27 | W |
| Mar 06 | Europa League | Plzen 1–2LazioRound of 16 | W |
| Mar 10 | Serie A | Lazio1–1UdineseRegular Season - 28 | D |
| Mar 13 | Europa League | Lazio1–1PlzenRound of 16 | D |
| Mar 16 | Serie A | Bologna5–0LazioRegular Season - 29 | L |
| Mar 31 | Serie A | Lazio1–1TorinoRegular Season - 30 | D |
| April 2025Apr 06 | Serie A | Atalanta0–1LazioRegular Season - 31 | W |
| Apr 10 | Europa League | Bodo/Glimt 2–0LazioQuarter-finals | L |
| Apr 13 | Serie A | Lazio1–1AS RomaRegular Season - 32 | D |
| Apr 17 | Europa League | Lazio3–1Bodo/GlimtQuarter-finals | W |
| Apr 23 | Serie A | Genoa0–2LazioRegular Season - 33 | W |
| Apr 28 | Serie A | Lazio2–2ParmaRegular Season - 34 | D |
| May 2025May 04 | Serie A | Empoli0–1LazioRegular Season - 35 | W |
| May 10 | Serie A | Lazio1–1JuventusRegular Season - 36 | D |
| May 18 | Serie A | Inter2–2LazioRegular Season - 37 | D |
| May 25 | Serie A | Lazio0–1LecceRegular Season - 38 | L |
