| August 2025Aug 24 |  Serie A | Como 2–0 LazioRegular Season - 1 | L |
| Aug 31 | Serie A | Lazio4–0 Hellas VeronaRegular Season - 2 | W |
| September 2025Sep 14 | Serie A | Sassuolo 1–0LazioRegular Season - 3 | L |
| Sep 21 | Serie A | Lazio0–1 AS RomaRegular Season - 4 | L |
| Sep 29 | Serie A | Genoa 0–3LazioRegular Season - 5 | W |
| October 2025Oct 04 | Serie A | Lazio3–3 TorinoRegular Season - 6 | D |
| Oct 19 | Serie A | Atalanta 0–0LazioRegular Season - 7 | D |
| Oct 26 | Serie A | Lazio1–0 JuventusRegular Season - 8 | W |
| Oct 30 | Serie A | Pisa 0–0LazioRegular Season - 9 | D |
| November 2025Nov 03 | Serie A | Lazio2–0 CagliariRegular Season - 10 | W |
| Nov 09 | Serie A | Inter 2–0LazioRegular Season - 11 | L |
| Nov 23 | Serie A | Lazio2–0 LecceRegular Season - 12 | W |
| Nov 29 | Serie A | AC Milan 1–0LazioRegular Season - 13 | L |
| December 2025Dec 07 | Serie A | Lazio1–1 BolognaRegular Season - 14 | D |
| Dec 13 | Serie A | Parma 0–1LazioRegular Season - 15 | W |
| Dec 20 | Serie A | Lazio0–0 CremoneseRegular Season - 16 | D |
| Dec 27 | Serie A | Udinese 1–1LazioRegular Season - 17 | D |
| January 2026Jan 04 | Serie A | Lazio0–2 NapoliRegular Season - 18 | L |
| Jan 07 | Serie A | Lazio2–2 FiorentinaRegular Season - 19 | D |
| Jan 11 | Serie A | Hellas Verona0–1LazioRegular Season - 20 | W |
| Jan 19 | Serie A | Lazio0–3ComoRegular Season - 21 | L |
| Jan 24 | Serie A | Lecce0–0LazioRegular Season - 22 | D |
| Jan 30 | Serie A | Lazio3–2GenoaRegular Season - 23 | W |
| February 2026Feb 08 | Serie A | Juventus2–2LazioRegular Season - 24 | D |
| Feb 14 | Serie A | Lazio0–2AtalantaRegular Season - 25 | L |
| Feb 21 | Serie A | Cagliari0–0LazioRegular Season - 26 | D |
| March 2026Mar 01 | Serie A | Torino2–0LazioRegular Season - 27 | L |
| Mar 09 | Serie A | Lazio2–1SassuoloRegular Season - 28 | W |
| Mar 15 | Serie A | Lazio1–0AC MilanRegular Season - 29 | W |
| Mar 22 | Serie A | Bologna0–2LazioRegular Season - 30 | W |
| April 2026Apr 04 | Serie A | Lazio1–1ParmaRegular Season - 31 | D |
| Apr 13 | Serie A | Fiorentina1–0LazioRegular Season - 32 | L |
| Apr 18 | Serie A | Napoli0–2LazioRegular Season - 33 | W |
| Apr 27 | Serie A | Lazio3–3UdineseRegular Season - 34 | D |
| May 2026May 04 | Serie A | Cremonese1–2LazioRegular Season - 35 | W |
| May 09 | Serie A | Lazio0–3InterRegular Season - 36 | L |
| May 17 | Serie A | AS Roma2–0LazioRegular Season - 37 | L |
| May 23 | Serie A | Lazio2–1PisaRegular Season - 38 | W |
