| August 2025Aug 16 |  Ligue 1 | Lens 0–1 LyonRegular Season - 1 | W |
| Aug 23 | Ligue 1 | Lyon3–0 MetzRegular Season - 2 | W |
| Aug 31 | Ligue 1 | Lyon1–0 MarseilleRegular Season - 3 | W |
| September 2025Sep 14 | Ligue 1 | Rennes 3–1LyonRegular Season - 4 | L |
| Sep 19 | Ligue 1 | Lyon1–0 AngersRegular Season - 5 | W |
| Sep 25 |  Europa League | Utrecht 0–1LyonLeague Stage - 1 | W |
| Sep 28 | Ligue 1 | Lille 0–1LyonRegular Season - 6 | W |
| October 2025Oct 02 | Europa League | Lyon2–0 Red Bull SalzburgLeague Stage - 2 | W |
| Oct 05 | Ligue 1 | Lyon1–2 ToulouseRegular Season - 7 | L |
| Oct 18 | Ligue 1 | Nice 3–2LyonRegular Season - 8 | L |
| Oct 23 | Europa League | Lyon2–0 FC Basel 1893League Stage - 3 | W |
| Oct 26 | Ligue 1 | Lyon2–1 StrasbourgRegular Season - 9 | W |
| Oct 29 | Ligue 1 | Paris FC 3–3LyonRegular Season - 10 | D |
| November 2025Nov 02 | Ligue 1 | Stade Brestois 29 0–0LyonRegular Season - 11 | D |
| Nov 06 | Europa League | Real Betis 2–0LyonLeague Stage - 4 | L |
| Nov 09 | Ligue 1 | Lyon2–3 Paris Saint GermainRegular Season - 12 | L |
| Nov 23 | Ligue 1 | Auxerre 0–0LyonRegular Season - 13 | D |
| Nov 27 | Europa League | Maccabi Tel Aviv 0–6LyonLeague Stage - 5 | W |
| Nov 30 | Ligue 1 | Lyon3–0 NantesRegular Season - 14 | W |
| December 2025Dec 07 | Ligue 1 | Lorient 1–0LyonRegular Season - 15 | L |
| Dec 11 | Europa League | Lyon2–1 GO Ahead EaglesLeague Stage - 6 | W |
| Dec 14 | Ligue 1 | Lyon1–0 Le HavreRegular Season - 16 | W |
| January 2026Jan 03 | Ligue 1 | Monaco 1–3LyonRegular Season - 17 | W |
| Jan 18 | Ligue 1 | Lyon2–1Stade Brestois 29Regular Season - 18 | W |
| Jan 22 | Europa League | BSC Young Boys 0–1LyonLeague Stage - 7 | W |
| Jan 25 | Ligue 1 | Metz2–5LyonRegular Season - 19 | W |
| Jan 29 | Europa League | Lyon4–2 PAOKLeague Stage - 8 | W |
| February 2026Feb 01 | Ligue 1 | Lyon1–0LilleRegular Season - 20 | W |
| Feb 07 | Ligue 1 | Nantes0–1LyonRegular Season - 21 | W |
| Feb 15 | Ligue 1 | Lyon2–0NiceRegular Season - 22 | W |
| Feb 22 | Ligue 1 | Strasbourg3–1LyonRegular Season - 23 | L |
| March 2026Mar 01 | Ligue 1 | Marseille3–2LyonRegular Season - 24 | L |
| Mar 08 | Ligue 1 | Lyon1–1Paris FCRegular Season - 25 | D |
| Mar 12 | Europa League | Celta Vigo 1–1LyonRound of 16 | D |
| Mar 15 | Ligue 1 | Le Havre0–0LyonRegular Season - 26 | D |
| Mar 19 | Europa League | Lyon0–2Celta VigoRound of 16 | L |
| Mar 22 | Ligue 1 | Lyon1–2MonacoRegular Season - 27 | L |
| April 2026Apr 05 | Ligue 1 | Angers0–0LyonRegular Season - 28 | D |
| Apr 12 | Ligue 1 | Lyon2–0LorientRegular Season - 29 | W |
| Apr 19 | Ligue 1 | Paris Saint Germain1–2LyonRegular Season - 30 | W |
| Apr 25 | Ligue 1 | Lyon3–2AuxerreRegular Season - 31 | W |
| May 2026May 03 | Ligue 1 | Lyon4–2RennesRegular Season - 32 | W |
| May 10 | Ligue 1 | Toulouse2–1LyonRegular Season - 33 | L |
| May 17 | Ligue 1 | Lyon0–4LensRegular Season - 34 | L |
