| August 2025Aug 16 |  Premier League | Aston Villa 0–0 NewcastleRegular Season - 1 | D |
| Aug 25 | Premier League | Newcastle2–3 LiverpoolRegular Season - 2 | L |
| Aug 30 | Premier League | Leeds 0–0NewcastleRegular Season - 3 | D |
| September 2025Sep 13 | Premier League | Newcastle1–0 WolvesRegular Season - 4 | W |
| Sep 18 |  Champions League | Newcastle1–2 BarcelonaLeague Stage - 1 | L |
| Sep 21 | Premier League | Bournemouth 0–0NewcastleRegular Season - 5 | D |
| Sep 28 | Premier League | Newcastle1–2 ArsenalRegular Season - 6 | L |
| October 2025Oct 01 | Champions League | Union St. Gilloise 0–4NewcastleLeague Stage - 2 | W |
| Oct 05 | Premier League | Newcastle2–0 Nottingham ForestRegular Season - 7 | W |
| Oct 18 | Premier League | Brighton 2–1NewcastleRegular Season - 8 | L |
| Oct 21 | Champions League | Newcastle3–0 BenficaLeague Stage - 3 | W |
| Oct 25 | Premier League | Newcastle2–1 FulhamRegular Season - 9 | W |
| November 2025Nov 02 | Premier League | West Ham 3–1NewcastleRegular Season - 10 | L |
| Nov 05 | Champions League | Newcastle2–0 Athletic ClubLeague Stage - 4 | W |
| Nov 09 | Premier League | Brentford 3–1NewcastleRegular Season - 11 | L |
| Nov 22 | Premier League | Newcastle2–1 Manchester CityRegular Season - 12 | W |
| Nov 25 | Champions League | Marseille 2–1NewcastleLeague Stage - 5 | L |
| Nov 29 | Premier League | Everton 1–4NewcastleRegular Season - 13 | W |
| December 2025Dec 02 | Premier League | Newcastle2–2 TottenhamRegular Season - 14 | D |
| Dec 06 | Premier League | Newcastle2–1 BurnleyRegular Season - 15 | W |
| Dec 10 | Champions League | Bayer Leverkusen 2–2NewcastleLeague Stage - 6 | D |
| Dec 14 | Premier League | Sunderland 1–0NewcastleRegular Season - 16 | L |
| Dec 20 | Premier League | Newcastle2–2 ChelseaRegular Season - 17 | D |
| Dec 26 | Premier League | Manchester United 1–0NewcastleRegular Season - 18 | L |
| Dec 30 | Premier League | Burnley1–3NewcastleRegular Season - 19 | W |
| January 2026Jan 04 | Premier League | Newcastle2–0 Crystal PalaceRegular Season - 20 | W |
| Jan 07 | Premier League | Newcastle4–3LeedsRegular Season - 21 | W |
| Jan 18 | Premier League | Wolves0–0NewcastleRegular Season - 22 | D |
| Jan 21 | Champions League | Newcastle3–0 PSV EindhovenLeague Stage - 7 | W |
| Jan 25 | Premier League | Newcastle0–2Aston VillaRegular Season - 23 | L |
| Jan 28 | Champions League | Paris Saint Germain 1–1NewcastleLeague Stage - 8 | D |
| Jan 31 | Premier League | Liverpool4–1NewcastleRegular Season - 24 | L |
| February 2026Feb 07 | Premier League | Newcastle2–3BrentfordRegular Season - 25 | L |
| Feb 10 | Premier League | Tottenham1–2NewcastleRegular Season - 26 | W |
| Feb 18 | Champions League | Qarabag 1–6NewcastleRound of 32 | W |
| Feb 21 | Premier League | Manchester City2–1NewcastleRegular Season - 27 | L |
| Feb 24 | Champions League | Newcastle3–2QarabagRound of 32 | W |
| Feb 28 | Premier League | Newcastle2–3EvertonRegular Season - 28 | L |
| March 2026Mar 04 | Premier League | Newcastle2–1Manchester UnitedRegular Season - 29 | W |
| Mar 10 | Champions League | Newcastle1–1BarcelonaRound of 16 | D |
| Mar 14 | Premier League | Chelsea0–1NewcastleRegular Season - 30 | W |
| Mar 18 | Champions League | Barcelona7–2NewcastleRound of 16 | L |
| Mar 22 | Premier League | Newcastle1–2SunderlandRegular Season - 31 | L |
| April 2026Apr 12 | Premier League | Crystal Palace2–1NewcastleRegular Season - 32 | L |
| Apr 18 | Premier League | Newcastle1–2BournemouthRegular Season - 33 | L |
| Apr 25 | Premier League | Arsenal1–0NewcastleRegular Season - 34 | L |
| May 2026May 02 | Premier League | Newcastle3–1BrightonRegular Season - 35 | W |
| May 10 | Premier League | Nottingham Forest1–1NewcastleRegular Season - 36 | D |
| May 17 | Premier League | Newcastle3–1West HamRegular Season - 37 | W |
| May 24 | Premier League | Fulham2–0NewcastleRegular Season - 38 | L |
