| August 2022Aug 06 |  Coppa Italia | Empoli 1–2 Spal1st Round | W |
| Aug 14 |  Serie B | Spal1–3 RegginaRegular Season - 1 | L |
| Aug 20 | Serie B | Ascoli 1–1SpalRegular Season - 2 | D |
| Aug 27 | Serie B | Spal1–0 CagliariRegular Season - 3 | W |
| September 2022Sep 03 | Serie B | Bari 2–2SpalRegular Season - 4 | D |
| Sep 11 | Serie B | Spal2–0 VeneziaRegular Season - 5 | W |
| Sep 17 | Serie B | Como 3–3SpalRegular Season - 6 | D |
| October 2022Oct 01 | Serie B | Spal0–2 GenoaRegular Season - 7 | L |
| Oct 08 | Serie B | Frosinone 2–0SpalRegular Season - 8 | L |
| Oct 15 | Serie B | Cittadella 0–0SpalRegular Season - 9 | D |
| Oct 18 | Coppa Italia | Genoa1–0Spal2nd Round | L |
| Oct 22 | Serie B | Spal5–0 CosenzaRegular Season - 10 | W |
| Oct 29 | Serie B | Spal1–1 SudtirolRegular Season - 11 | D |
| November 2022Nov 05 | Serie B | Ternana 0–0SpalRegular Season - 12 | D |
| Nov 12 | Serie B | Spal1–2 BeneventoRegular Season - 13 | L |
| Nov 27 | Serie B | Brescia 2–0SpalRegular Season - 14 | L |
| December 2022Dec 04 | Serie B | Spal2–3 ModenaRegular Season - 15 | L |
| Dec 08 | Serie B | Perugia 0–0SpalRegular Season - 16 | D |
| Dec 11 | Serie B | Spal1–1 PalermoRegular Season - 17 | D |
| Dec 18 | Serie B | Parma 0–1SpalRegular Season - 18 | W |
| Dec 26 | Serie B | Spal0–1 PisaRegular Season - 19 | L |
| January 2023Jan 14 | Serie B | Reggina0–1SpalRegular Season - 20 | W |
| Jan 21 | Serie B | Spal1–1AscoliRegular Season - 21 | D |
| Jan 27 | Serie B | Cagliari2–1SpalRegular Season - 22 | L |
| February 2023Feb 04 | Serie B | Spal3–4BariRegular Season - 23 | L |
| Feb 11 | Serie B | Venezia2–1SpalRegular Season - 24 | L |
| Feb 18 | Serie B | Spal1–1ComoRegular Season - 25 | D |
| Feb 25 | Serie B | Genoa3–0SpalRegular Season - 26 | L |
| March 2023Mar 01 | Serie B | Spal0–2FrosinoneRegular Season - 27 | L |
| Mar 05 | Serie B | Spal2–1CittadellaRegular Season - 28 | W |
| Mar 12 | Serie B | Cosenza1–0SpalRegular Season - 29 | L |
| Mar 18 | Serie B | Sudtirol2–0SpalRegular Season - 30 | L |
| April 2023Apr 01 | Serie B | Spal1–1TernanaRegular Season - 31 | D |
| Apr 10 | Serie B | Benevento1–3SpalRegular Season - 32 | W |
| Apr 15 | Serie B | Spal2–2BresciaRegular Season - 33 | D |
| Apr 22 | Serie B | Modena0–0SpalRegular Season - 34 | D |
| Apr 30 | Serie B | Spal1–1PerugiaRegular Season - 35 | D |
| May 2023May 06 | Serie B | Palermo2–1SpalRegular Season - 36 | L |
| May 13 | Serie B | Spal0–1ParmaRegular Season - 37 | L |
| May 19 | Serie B | Pisa1–2SpalRegular Season - 38 | W |
