| August 2017Aug 20 |  Serie A | Lazio 0–0 SpalRegular Season - 1 | D |
| Aug 27 | Serie A | Spal3–2 UdineseRegular Season - 2 | W |
| September 2017Sep 10 | Serie A | Inter 2–0SpalRegular Season - 3 | L |
| Sep 17 | Serie A | Spal0–2 CagliariRegular Season - 4 | L |
| Sep 20 | Serie A | AC Milan 2–0SpalRegular Season - 5 | L |
| Sep 23 | Serie A | Spal2–3 NapoliRegular Season - 6 | L |
| October 2017Oct 01 | Serie A | Spal1–1 CrotoneRegular Season - 7 | D |
| Oct 15 | Serie A | Bologna 2–1SpalRegular Season - 8 | L |
| Oct 22 | Serie A | Spal0–1 SassuoloRegular Season - 9 | L |
| Oct 25 | Serie A | Juventus 4–1SpalRegular Season - 10 | L |
| Oct 29 | Serie A | Spal1–0 GenoaRegular Season - 11 | W |
| November 2017Nov 05 | Serie A | Atalanta 1–1SpalRegular Season - 12 | D |
| Nov 19 | Serie A | Spal1–1 FiorentinaRegular Season - 13 | D |
| Nov 25 | Serie A | Chievo 2–1SpalRegular Season - 14 | L |
| December 2017Dec 01 | Serie A | AS Roma 3–1SpalRegular Season - 15 | L |
| Dec 10 | Serie A | Spal2–2 Hellas VeronaRegular Season - 16 | D |
| Dec 17 | Serie A | Benevento 1–2SpalRegular Season - 17 | W |
| Dec 23 | Serie A | Spal2–2 TorinoRegular Season - 18 | D |
| Dec 30 | Serie A | Sampdoria 2–0SpalRegular Season - 19 | L |
| January 2018Jan 06 | Serie A | Spal2–5LazioRegular Season - 20 | L |
| Jan 21 | Serie A | Udinese1–1SpalRegular Season - 21 | D |
| Jan 28 | Serie A | Spal1–1InterRegular Season - 22 | D |
| February 2018Feb 04 | Serie A | Cagliari2–0SpalRegular Season - 23 | L |
| Feb 10 | Serie A | Spal0–4AC MilanRegular Season - 24 | L |
| Feb 18 | Serie A | Napoli1–0SpalRegular Season - 25 | L |
| Feb 25 | Serie A | Crotone2–3SpalRegular Season - 26 | W |
| March 2018Mar 03 | Serie A | Spal1–0BolognaRegular Season - 27 | W |
| Mar 11 | Serie A | Sassuolo1–1SpalRegular Season - 28 | D |
| Mar 17 | Serie A | Spal0–0JuventusRegular Season - 29 | D |
| Mar 31 | Serie A | Genoa1–1SpalRegular Season - 30 | D |
| April 2018Apr 07 | Serie A | Spal1–1AtalantaRegular Season - 31 | D |
| Apr 15 | Serie A | Fiorentina0–0SpalRegular Season - 32 | D |
| Apr 18 | Serie A | Spal0–0ChievoRegular Season - 33 | D |
| Apr 21 | Serie A | Spal0–3AS RomaRegular Season - 34 | L |
| Apr 29 | Serie A | Hellas Verona1–3SpalRegular Season - 35 | W |
| May 2018May 06 | Serie A | Spal2–0BeneventoRegular Season - 36 | W |
| May 13 | Serie A | Torino2–1SpalRegular Season - 37 | L |
| May 20 | Serie A | Spal3–1SampdoriaRegular Season - 38 | W |
