| agost del 202121 d’ag. |  Serie A | Inter 4–0 GenoaRegular Season - 1 | V |
| 27 d’ag. | Serie A | Hellas Verona 1–3InterRegular Season - 2 | V |
| setembre del 202112 de set. | Serie A | Sampdoria 2–2InterRegular Season - 3 | E |
| 15 de set. |  Champions League | Inter0–1 Real MadridGroup Stage - 1 | D |
| 18 de set. | Serie A | Inter6–1 BolognaRegular Season - 4 | V |
| 21 de set. | Serie A | Fiorentina 1–3InterRegular Season - 5 | V |
| 25 de set. | Serie A | Inter2–2 AtalantaRegular Season - 6 | E |
| 28 de set. | Champions League | Shakhtar Donetsk 0–0InterGroup Stage - 2 | E |
| octubre del 202102 d’oct. | Serie A | Sassuolo 1–2InterRegular Season - 7 | V |
| 16 d’oct. | Serie A | Lazio 3–1InterRegular Season - 8 | D |
| 19 d’oct. | Champions League | Inter3–1 Sheriff TiraspolGroup Stage - 3 | V |
| 24 d’oct. | Serie A | Inter1–1 JuventusRegular Season - 9 | E |
| 27 d’oct. | Serie A | Empoli 0–2InterRegular Season - 10 | V |
| 31 d’oct. | Serie A | Inter2–0 UdineseRegular Season - 11 | V |
| novembre del 202103 de nov. | Champions League | Sheriff Tiraspol1–3InterGroup Stage - 4 | V |
| 07 de nov. | Serie A | AC Milan 1–1InterRegular Season - 12 | E |
| 21 de nov. | Serie A | Inter3–2 NapoliRegular Season - 13 | V |
| 24 de nov. | Champions League | Inter2–0Shakhtar DonetskGroup Stage - 5 | V |
| 27 de nov. | Serie A | Venezia 0–2InterRegular Season - 14 | V |
| desembre del 202101 de des. | Serie A | Inter2–0 SpeziaRegular Season - 15 | V |
| 04 de des. | Serie A | AS Roma 0–3InterRegular Season - 16 | V |
| 07 de des. | Champions League | Real Madrid2–0InterGroup Stage - 6 | D |
| 12 de des. | Serie A | Inter4–0 CagliariRegular Season - 17 | V |
| 17 de des. | Serie A | Salernitana 0–5InterRegular Season - 18 | V |
| 22 de des. | Serie A | Inter1–0 TorinoRegular Season - 19 | V |
| gener del 202209 de gen. | Serie A | Inter2–1LazioRegular Season - 21 | V |
| 16 de gen. | Serie A | Atalanta0–0InterRegular Season - 22 | E |
| 22 de gen. | Serie A | Inter2–1VeneziaRegular Season - 23 | V |
| febrer del 202205 de febr. | Serie A | Inter1–2AC MilanRegular Season - 24 | D |
| 12 de febr. | Serie A | Napoli1–1InterRegular Season - 25 | E |
| 16 de febr. | Champions League | Inter0–2 LiverpoolRound of 16 | D |
| 20 de febr. | Serie A | Inter0–2SassuoloRegular Season - 26 | D |
| 25 de febr. | Serie A | Genoa0–0InterRegular Season - 27 | E |
| març del 202204 de març | Serie A | Inter5–0SalernitanaRegular Season - 28 | V |
| 08 de març | Champions League | Liverpool0–1InterRound of 16 | V |
| 13 de març | Serie A | Torino1–1InterRegular Season - 29 | E |
| 19 de març | Serie A | Inter1–1FiorentinaRegular Season - 30 | E |
| abril del 202203 d’abr. | Serie A | Juventus0–1InterRegular Season - 31 | V |
| 09 d’abr. | Serie A | Inter2–0Hellas VeronaRegular Season - 32 | V |
| 15 d’abr. | Serie A | Spezia1–3InterRegular Season - 33 | V |
| 23 d’abr. | Serie A | Inter3–1AS RomaRegular Season - 34 | V |
| 27 d’abr. | Serie A | Bologna2–1InterRegular Season - 20 | D |
| maig del 202201 de maig | Serie A | Udinese1–2InterRegular Season - 35 | V |
| 06 de maig | Serie A | Inter4–2EmpoliRegular Season - 36 | V |
| 15 de maig | Serie A | Cagliari1–3InterRegular Season - 37 | V |
| 22 de maig | Serie A | Inter3–0SampdoriaRegular Season - 38 | V |
