| août 202121 août |  Serie A | Inter 4–0 GenoaRegular Season - 1 | V |
| 27 août | Serie A | Hellas Verona 1–3InterRegular Season - 2 | V |
| septembre 202112 sept. | Serie A | Sampdoria 2–2InterRegular Season - 3 | N |
| 18 sept. | Serie A | Inter6–1 BolognaRegular Season - 4 | V |
| 21 sept. | Serie A | Fiorentina 1–3InterRegular Season - 5 | V |
| 25 sept. | Serie A | Inter2–2 AtalantaRegular Season - 6 | N |
| octobre 202102 oct. | Serie A | Sassuolo 1–2InterRegular Season - 7 | V |
| 16 oct. | Serie A | Lazio 3–1InterRegular Season - 8 | D |
| 24 oct. | Serie A | Inter1–1 JuventusRegular Season - 9 | N |
| 27 oct. | Serie A | Empoli 0–2InterRegular Season - 10 | V |
| 31 oct. | Serie A | Inter2–0 UdineseRegular Season - 11 | V |
| novembre 202107 nov. | Serie A | AC Milan 1–1InterRegular Season - 12 | N |
| 21 nov. | Serie A | Inter3–2 NapoliRegular Season - 13 | V |
| 27 nov. | Serie A | Venezia 0–2InterRegular Season - 14 | V |
| décembre 202101 déc. | Serie A | Inter2–0 SpeziaRegular Season - 15 | V |
| 04 déc. | Serie A | AS Roma 0–3InterRegular Season - 16 | V |
| 12 déc. | Serie A | Inter4–0 CagliariRegular Season - 17 | V |
| 17 déc. | Serie A | Salernitana 0–5InterRegular Season - 18 | V |
| 22 déc. | Serie A | Inter1–0 TorinoRegular Season - 19 | V |
| janvier 202209 janv. | Serie A | Inter2–1LazioRegular Season - 21 | V |
| 16 janv. | Serie A | Atalanta0–0InterRegular Season - 22 | N |
| 22 janv. | Serie A | Inter2–1VeneziaRegular Season - 23 | V |
| février 202205 févr. | Serie A | Inter1–2AC MilanRegular Season - 24 | D |
| 12 févr. | Serie A | Napoli1–1InterRegular Season - 25 | N |
| 20 févr. | Serie A | Inter0–2SassuoloRegular Season - 26 | D |
| 25 févr. | Serie A | Genoa0–0InterRegular Season - 27 | N |
| mars 202204 mars | Serie A | Inter5–0SalernitanaRegular Season - 28 | V |
| 13 mars | Serie A | Torino1–1InterRegular Season - 29 | N |
| 19 mars | Serie A | Inter1–1FiorentinaRegular Season - 30 | N |
| avril 202203 avr. | Serie A | Juventus0–1InterRegular Season - 31 | V |
| 09 avr. | Serie A | Inter2–0Hellas VeronaRegular Season - 32 | V |
| 15 avr. | Serie A | Spezia1–3InterRegular Season - 33 | V |
| 23 avr. | Serie A | Inter3–1AS RomaRegular Season - 34 | V |
| 27 avr. | Serie A | Bologna2–1InterRegular Season - 20 | D |
| mai 202201 mai | Serie A | Udinese1–2InterRegular Season - 35 | V |
| 06 mai | Serie A | Inter4–2EmpoliRegular Season - 36 | V |
| 15 mai | Serie A | Cagliari1–3InterRegular Season - 37 | V |
| 22 mai | Serie A | Inter3–0SampdoriaRegular Season - 38 | V |
