| August 2021Aug 21 |  Serie A | Inter 4–0 GenoaRegular Season - 1 | W |
| Aug 27 | Serie A | Hellas Verona 1–3InterRegular Season - 2 | W |
| September 2021Sep 12 | Serie A | Sampdoria 2–2InterRegular Season - 3 | D |
| Sep 18 | Serie A | Inter6–1 BolognaRegular Season - 4 | W |
| Sep 21 | Serie A | Fiorentina 1–3InterRegular Season - 5 | W |
| Sep 25 | Serie A | Inter2–2 AtalantaRegular Season - 6 | D |
| October 2021Oct 02 | Serie A | Sassuolo 1–2InterRegular Season - 7 | W |
| Oct 16 | Serie A | Lazio 3–1InterRegular Season - 8 | L |
| Oct 24 | Serie A | Inter1–1 JuventusRegular Season - 9 | D |
| Oct 27 | Serie A | Empoli 0–2InterRegular Season - 10 | W |
| Oct 31 | Serie A | Inter2–0 UdineseRegular Season - 11 | W |
| November 2021Nov 07 | Serie A | AC Milan 1–1InterRegular Season - 12 | D |
| Nov 21 | Serie A | Inter3–2 NapoliRegular Season - 13 | W |
| Nov 27 | Serie A | Venezia 0–2InterRegular Season - 14 | W |
| December 2021Dec 01 | Serie A | Inter2–0 SpeziaRegular Season - 15 | W |
| Dec 04 | Serie A | AS Roma 0–3InterRegular Season - 16 | W |
| Dec 12 | Serie A | Inter4–0 CagliariRegular Season - 17 | W |
| Dec 17 | Serie A | Salernitana 0–5InterRegular Season - 18 | W |
| Dec 22 | Serie A | Inter1–0 TorinoRegular Season - 19 | W |
| January 2022Jan 09 | Serie A | Inter2–1LazioRegular Season - 21 | W |
| Jan 16 | Serie A | Atalanta0–0InterRegular Season - 22 | D |
| Jan 22 | Serie A | Inter2–1VeneziaRegular Season - 23 | W |
| February 2022Feb 05 | Serie A | Inter1–2AC MilanRegular Season - 24 | L |
| Feb 12 | Serie A | Napoli1–1InterRegular Season - 25 | D |
| Feb 20 | Serie A | Inter0–2SassuoloRegular Season - 26 | L |
| Feb 25 | Serie A | Genoa0–0InterRegular Season - 27 | D |
| March 2022Mar 04 | Serie A | Inter5–0SalernitanaRegular Season - 28 | W |
| Mar 13 | Serie A | Torino1–1InterRegular Season - 29 | D |
| Mar 19 | Serie A | Inter1–1FiorentinaRegular Season - 30 | D |
| April 2022Apr 03 | Serie A | Juventus0–1InterRegular Season - 31 | W |
| Apr 09 | Serie A | Inter2–0Hellas VeronaRegular Season - 32 | W |
| Apr 15 | Serie A | Spezia1–3InterRegular Season - 33 | W |
| Apr 23 | Serie A | Inter3–1AS RomaRegular Season - 34 | W |
| Apr 27 | Serie A | Bologna2–1InterRegular Season - 20 | L |
| May 2022May 01 | Serie A | Udinese1–2InterRegular Season - 35 | W |
| May 06 | Serie A | Inter4–2EmpoliRegular Season - 36 | W |
| May 15 | Serie A | Cagliari1–3InterRegular Season - 37 | W |
| May 22 | Serie A | Inter3–0SampdoriaRegular Season - 38 | W |
