| agost del 201614 d’ag. |  Ligue 1 | Nancy 0–3 LyonRegular Season - 1 | V |
| 19 d’ag. | Ligue 1 | Lyon2–0 CaenRegular Season - 2 | V |
| 27 d’ag. | Ligue 1 | Dijon 4–2LyonRegular Season - 3 | D |
| setembre del 201610 de set. | Ligue 1 | Lyon1–3 BordeauxRegular Season - 4 | D |
| 14 de set. |  Champions League | Lyon3–0 Dinamo ZagrebGroup Stage - 1 | V |
| 18 de set. | Ligue 1 | Marseille 0–0LyonRegular Season - 5 | E |
| 21 de set. | Ligue 1 | Lyon5–1 MontpellierRegular Season - 6 | V |
| 24 de set. | Ligue 1 | Lorient 1–0LyonRegular Season - 7 | D |
| 27 de set. | Champions League | Sevilla 1–0LyonGroup Stage - 2 | D |
| octubre del 201602 d’oct. | Ligue 1 | Lyon2–0 Saint EtienneRegular Season - 8 | V |
| 14 d’oct. | Ligue 1 | Nice 2–0LyonRegular Season - 9 | D |
| 18 d’oct. | Champions League | Lyon0–1 JuventusGroup Stage - 3 | D |
| 22 d’oct. | Ligue 1 | Lyon1–3 GuingampRegular Season - 10 | D |
| 29 d’oct. | Ligue 1 | Toulouse 1–2LyonRegular Season - 11 | V |
| novembre del 201602 de nov. | Champions League | Juventus1–1LyonGroup Stage - 4 | E |
| 05 de nov. | Ligue 1 | Lyon2–1 BastiaRegular Season - 12 | V |
| 18 de nov. | Ligue 1 | Lille 0–1LyonRegular Season - 13 | V |
| 22 de nov. | Champions League | Dinamo Zagreb0–1LyonGroup Stage - 5 | V |
| 27 de nov. | Ligue 1 | Lyon1–2 Paris Saint GermainRegular Season - 14 | D |
| 30 de nov. | Ligue 1 | Nantes 0–6LyonRegular Season - 15 | V |
| desembre del 201607 de des. | Champions League | Lyon0–0SevillaGroup Stage - 6 | E |
| 11 de des. | Ligue 1 | Lyon1–0 RennesRegular Season - 17 | V |
| 18 de des. | Ligue 1 | Monaco 1–3LyonRegular Season - 18 | V |
| 21 de des. | Ligue 1 | Lyon2–0 AngersRegular Season - 19 | V |
| gener del 201715 de gen. | Ligue 1 | Caen3–2LyonRegular Season - 20 | D |
| 22 de gen. | Ligue 1 | Lyon3–1MarseilleRegular Season - 21 | V |
| 28 de gen. | Ligue 1 | Lyon1–2LilleRegular Season - 22 | D |
| febrer del 201705 de febr. | Ligue 1 | Saint Etienne2–0LyonRegular Season - 23 | D |
| 08 de febr. | Ligue 1 | Lyon4–0NancyRegular Season - 24 | V |
| 11 de febr. | Ligue 1 | Guingamp2–1LyonRegular Season - 25 | D |
| 16 de febr. |  Europa League | AZ Alkmaar 1–4Lyon16th Finals | V |
| 19 de febr. | Ligue 1 | Lyon4–2DijonRegular Season - 26 | V |
| 23 de febr. | Europa League | Lyon7–1AZ Alkmaar16th Finals | V |
| 26 de febr. | Ligue 1 | Lyon5–0 MetzRegular Season - 27 | V |
| març del 201703 de març | Ligue 1 | Bordeaux1–1LyonRegular Season - 28 | E |
| 09 de març | Europa League | Lyon4–2 AS Roma8th Finals | V |
| 12 de març | Ligue 1 | Lyon4–0ToulouseRegular Season - 29 | V |
| 16 de març | Europa League | AS Roma2–1Lyon8th Finals | D |
| 19 de març | Ligue 1 | Paris Saint Germain2–1LyonRegular Season - 30 | D |
| abril del 201702 d’abr. | Ligue 1 | Rennes1–1LyonRegular Season - 31 | E |
| 05 d’abr. | Ligue 1 | Metz0–3LyonRegular Season - 16 | V |
| 08 d’abr. | Ligue 1 | Lyon1–4LorientRegular Season - 32 | D |
| 13 d’abr. | Europa League | Lyon2–1 BeşiktaşQuarter-finals | V |
| 16 d’abr. | Ligue 1 | Bastia0–0LyonRegular Season - 33 | E |
| 20 d’abr. | Europa League | Beşiktaş4–2LyonQuarter-finals | D |
| 23 d’abr. | Ligue 1 | Lyon1–2MonacoRegular Season - 34 | D |
| 28 d’abr. | Ligue 1 | Angers1–2LyonRegular Season - 35 | V |
| maig del 201703 de maig | Europa League | Ajax 4–1LyonSemi-finals | D |
| 07 de maig | Ligue 1 | Lyon3–2NantesRegular Season - 36 | V |
| 11 de maig | Europa League | Lyon3–1AjaxSemi-finals | V |
| 14 de maig | Ligue 1 | Montpellier1–3LyonRegular Season - 37 | V |
| 20 de maig | Ligue 1 | Lyon3–3NiceRegular Season - 38 | E |
