| August 2016Aug 14 |  Ligue 1 | Nancy 0–3 LyonRegular Season - 1 | W |
| Aug 19 | Ligue 1 | Lyon2–0 CaenRegular Season - 2 | W |
| Aug 27 | Ligue 1 | Dijon 4–2LyonRegular Season - 3 | L |
| September 2016Sep 10 | Ligue 1 | Lyon1–3 BordeauxRegular Season - 4 | L |
| Sep 14 |  Champions League | Lyon3–0 Dinamo ZagrebGroup Stage - 1 | W |
| Sep 18 | Ligue 1 | Marseille 0–0LyonRegular Season - 5 | D |
| Sep 21 | Ligue 1 | Lyon5–1 MontpellierRegular Season - 6 | W |
| Sep 24 | Ligue 1 | Lorient 1–0LyonRegular Season - 7 | L |
| Sep 27 | Champions League | Sevilla 1–0LyonGroup Stage - 2 | L |
| October 2016Oct 02 | Ligue 1 | Lyon2–0 Saint EtienneRegular Season - 8 | W |
| Oct 14 | Ligue 1 | Nice 2–0LyonRegular Season - 9 | L |
| Oct 18 | Champions League | Lyon0–1 JuventusGroup Stage - 3 | L |
| Oct 22 | Ligue 1 | Lyon1–3 GuingampRegular Season - 10 | L |
| Oct 29 | Ligue 1 | Toulouse 1–2LyonRegular Season - 11 | W |
| November 2016Nov 02 | Champions League | Juventus1–1LyonGroup Stage - 4 | D |
| Nov 05 | Ligue 1 | Lyon2–1 BastiaRegular Season - 12 | W |
| Nov 18 | Ligue 1 | Lille 0–1LyonRegular Season - 13 | W |
| Nov 22 | Champions League | Dinamo Zagreb0–1LyonGroup Stage - 5 | W |
| Nov 27 | Ligue 1 | Lyon1–2 Paris Saint GermainRegular Season - 14 | L |
| Nov 30 | Ligue 1 | Nantes 0–6LyonRegular Season - 15 | W |
| December 2016Dec 07 | Champions League | Lyon0–0SevillaGroup Stage - 6 | D |
| Dec 11 | Ligue 1 | Lyon1–0 RennesRegular Season - 17 | W |
| Dec 18 | Ligue 1 | Monaco 1–3LyonRegular Season - 18 | W |
| Dec 21 | Ligue 1 | Lyon2–0 AngersRegular Season - 19 | W |
| January 2017Jan 15 | Ligue 1 | Caen3–2LyonRegular Season - 20 | L |
| Jan 22 | Ligue 1 | Lyon3–1MarseilleRegular Season - 21 | W |
| Jan 28 | Ligue 1 | Lyon1–2LilleRegular Season - 22 | L |
| February 2017Feb 05 | Ligue 1 | Saint Etienne2–0LyonRegular Season - 23 | L |
| Feb 08 | Ligue 1 | Lyon4–0NancyRegular Season - 24 | W |
| Feb 11 | Ligue 1 | Guingamp2–1LyonRegular Season - 25 | L |
| Feb 16 |  Europa League | AZ Alkmaar 1–4Lyon16th Finals | W |
| Feb 19 | Ligue 1 | Lyon4–2DijonRegular Season - 26 | W |
| Feb 23 | Europa League | Lyon7–1AZ Alkmaar16th Finals | W |
| Feb 26 | Ligue 1 | Lyon5–0 MetzRegular Season - 27 | W |
| March 2017Mar 03 | Ligue 1 | Bordeaux1–1LyonRegular Season - 28 | D |
| Mar 09 | Europa League | Lyon4–2 AS Roma8th Finals | W |
| Mar 12 | Ligue 1 | Lyon4–0ToulouseRegular Season - 29 | W |
| Mar 16 | Europa League | AS Roma2–1Lyon8th Finals | L |
| Mar 19 | Ligue 1 | Paris Saint Germain2–1LyonRegular Season - 30 | L |
| April 2017Apr 02 | Ligue 1 | Rennes1–1LyonRegular Season - 31 | D |
| Apr 05 | Ligue 1 | Metz0–3LyonRegular Season - 16 | W |
| Apr 08 | Ligue 1 | Lyon1–4LorientRegular Season - 32 | L |
| Apr 13 | Europa League | Lyon2–1 BeşiktaşQuarter-finals | W |
| Apr 16 | Ligue 1 | Bastia0–0LyonRegular Season - 33 | D |
| Apr 20 | Europa League | Beşiktaş4–2LyonQuarter-finals | L |
| Apr 23 | Ligue 1 | Lyon1–2MonacoRegular Season - 34 | L |
| Apr 28 | Ligue 1 | Angers1–2LyonRegular Season - 35 | W |
| May 2017May 03 | Europa League | Ajax 4–1LyonSemi-finals | L |
| May 07 | Ligue 1 | Lyon3–2NantesRegular Season - 36 | W |
| May 11 | Europa League | Lyon3–1AjaxSemi-finals | W |
| May 14 | Ligue 1 | Montpellier1–3LyonRegular Season - 37 | W |
| May 20 | Ligue 1 | Lyon3–3NiceRegular Season - 38 | D |
