| August 2022Aug 05 |  Ligue 1 | Lyon 2–1 AjaccioRegular Season - 1 | W |
| Aug 19 | Ligue 1 | Lyon4–1 Estac TroyesRegular Season - 3 | W |
| Aug 28 | Ligue 1 | Reims 1–1LyonRegular Season - 4 | D |
| Aug 31 | Ligue 1 | Lyon2–1 AuxerreRegular Season - 5 | W |
| September 2022Sep 03 | Ligue 1 | Lyon5–0 AngersRegular Season - 6 | W |
| Sep 07 | Ligue 1 | Lorient 3–1LyonRegular Season - 2 | L |
| Sep 11 | Ligue 1 | Monaco 2–1LyonRegular Season - 7 | L |
| Sep 18 | Ligue 1 | Lyon0–1 Paris Saint GermainRegular Season - 8 | L |
| October 2022Oct 02 | Ligue 1 | Lens 1–0LyonRegular Season - 9 | L |
| Oct 07 | Ligue 1 | Lyon1–1 ToulouseRegular Season - 10 | D |
| Oct 16 | Ligue 1 | Rennes 3–2LyonRegular Season - 11 | L |
| Oct 22 | Ligue 1 | Montpellier 1–2LyonRegular Season - 12 | W |
| Oct 30 | Ligue 1 | Lyon1–0 LilleRegular Season - 13 | W |
| November 2022Nov 06 | Ligue 1 | Marseille 1–0LyonRegular Season - 14 | L |
| Nov 11 | Ligue 1 | Lyon1–1 NiceRegular Season - 15 | D |
| December 2022Dec 28 | Ligue 1 | Stade Brestois 29 2–4LyonRegular Season - 16 | W |
| January 2023Jan 01 | Ligue 1 | Lyon0–1 Clermont FootRegular Season - 17 | L |
| Jan 07 |  Coupe de France | Lyon2–1 MetzRound of 64 | W |
| Jan 11 | Ligue 1 | Nantes 0–0LyonRegular Season - 18 | D |
| Jan 14 | Ligue 1 | Lyon1–2 StrasbourgRegular Season - 19 | L |
| Jan 21 | Coupe de France | Chambéry 0–3LyonRound of 32 | W |
| Jan 29 | Ligue 1 | Ajaccio0–2LyonRegular Season - 20 | W |
| February 2023Feb 01 | Ligue 1 | Lyon0–0Stade Brestois 29Regular Season - 21 | D |
| Feb 04 | Ligue 1 | Estac Troyes1–3LyonRegular Season - 22 | W |
| Feb 08 | Coupe de France | Lyon2–2LilleRound of 16 | D |
| Feb 12 | Ligue 1 | Lyon2–1LensRegular Season - 23 | W |
| Feb 17 | Ligue 1 | Auxerre2–1LyonRegular Season - 24 | L |
| Feb 25 | Ligue 1 | Angers1–3LyonRegular Season - 25 | W |
| Feb 28 | Coupe de France | Lyon2–1 GrenobleQuarter-finals | W |
| March 2023Mar 05 | Ligue 1 | Lyon0–0LorientRegular Season - 26 | D |
| Mar 10 | Ligue 1 | Lille3–3LyonRegular Season - 27 | D |
| Mar 17 | Ligue 1 | Lyon1–1NantesRegular Season - 28 | D |
| April 2023Apr 02 | Ligue 1 | Paris Saint Germain0–1LyonRegular Season - 29 | W |
| Apr 05 | Coupe de France | Nantes1–0LyonSemi-finals | L |
| Apr 09 | Ligue 1 | Lyon3–1RennesRegular Season - 30 | W |
| Apr 14 | Ligue 1 | Toulouse1–2LyonRegular Season - 31 | W |
| Apr 23 | Ligue 1 | Lyon1–2MarseilleRegular Season - 32 | L |
| Apr 28 | Ligue 1 | Strasbourg1–2LyonRegular Season - 33 | W |
| May 2023May 07 | Ligue 1 | Lyon5–4MontpellierRegular Season - 34 | W |
| May 14 | Ligue 1 | Clermont Foot2–1LyonRegular Season - 35 | L |
| May 19 | Ligue 1 | Lyon3–1MonacoRegular Season - 36 | W |
| May 27 | Ligue 1 | Lyon3–0ReimsRegular Season - 37 | W |
| June 2023Jun 03 | Ligue 1 | Nice3–1LyonRegular Season - 38 | L |
