| August 2017Aug 05 |  Ligue 1 | Lyon 4–0 StrasbourgRegular Season - 1 | W |
| Aug 11 | Ligue 1 | Rennes 1–2LyonRegular Season - 2 | W |
| Aug 19 | Ligue 1 | Lyon3–3 BordeauxRegular Season - 3 | D |
| Aug 26 | Ligue 1 | Nantes 0–0LyonRegular Season - 4 | D |
| September 2017Sep 10 | Ligue 1 | Lyon2–1 GuingampRegular Season - 5 | W |
| Sep 14 |  Europa League | Apollon Limassol 1–1LyonGroup Stage - 1 | D |
| Sep 17 | Ligue 1 | Paris Saint Germain 2–0LyonRegular Season - 6 | L |
| Sep 23 | Ligue 1 | Lyon3–3 DijonRegular Season - 7 | D |
| Sep 28 | Europa League | Lyon1–1 AtalantaGroup Stage - 2 | D |
| October 2017Oct 01 | Ligue 1 | Angers 3–3LyonRegular Season - 8 | D |
| Oct 13 | Ligue 1 | Lyon3–2 MonacoRegular Season - 9 | W |
| Oct 19 | Europa League | Everton 1–2LyonGroup Stage - 3 | W |
| Oct 22 | Ligue 1 | Estac Troyes 0–5LyonRegular Season - 10 | W |
| Oct 29 | Ligue 1 | Lyon2–0 MetzRegular Season - 11 | W |
| November 2017Nov 02 | Europa League | Lyon3–0EvertonGroup Stage - 4 | W |
| Nov 05 | Ligue 1 | Saint Etienne 0–5LyonRegular Season - 12 | W |
| Nov 19 | Ligue 1 | Lyon0–0 MontpellierRegular Season - 13 | D |
| Nov 23 | Europa League | Lyon4–0Apollon LimassolGroup Stage - 5 | W |
| Nov 26 | Ligue 1 | Nice 0–5LyonRegular Season - 14 | W |
| Nov 29 | Ligue 1 | Lyon1–2 LilleRegular Season - 15 | L |
| December 2017Dec 03 | Ligue 1 | Caen 1–2LyonRegular Season - 16 | W |
| Dec 07 | Europa League | Atalanta1–0LyonGroup Stage - 6 | L |
| Dec 10 | Ligue 1 | Amiens 1–2LyonRegular Season - 17 | W |
| Dec 17 | Ligue 1 | Lyon2–0 MarseilleRegular Season - 18 | W |
| Dec 20 | Ligue 1 | Toulouse 1–2LyonRegular Season - 19 | W |
| January 2018Jan 14 | Ligue 1 | Lyon1–1AngersRegular Season - 20 | D |
| Jan 17 | Ligue 1 | Guingamp0–2LyonRegular Season - 21 | W |
| Jan 21 | Ligue 1 | Lyon2–1Paris Saint GermainRegular Season - 22 | W |
| Jan 28 | Ligue 1 | Bordeaux3–1LyonRegular Season - 23 | L |
| February 2018Feb 04 | Ligue 1 | Monaco3–2LyonRegular Season - 24 | L |
| Feb 11 | Ligue 1 | Lyon0–2RennesRegular Season - 25 | L |
| Feb 15 | Europa League | Lyon3–1 Villarreal16th Finals | W |
| Feb 18 | Ligue 1 | Lille2–2LyonRegular Season - 26 | D |
| Feb 22 | Europa League | Villarreal0–1Lyon16th Finals | W |
| Feb 25 | Ligue 1 | Lyon1–1Saint EtienneRegular Season - 27 | D |
| March 2018Mar 04 | Ligue 1 | Montpellier1–1LyonRegular Season - 28 | D |
| Mar 08 | Europa League | CSKA Moscow 0–1Lyon8th Finals | W |
| Mar 11 | Ligue 1 | Lyon1–0CaenRegular Season - 29 | W |
| Mar 15 | Europa League | Lyon2–3CSKA Moscow8th Finals | L |
| Mar 18 | Ligue 1 | Marseille2–3LyonRegular Season - 30 | W |
| April 2018Apr 01 | Ligue 1 | Lyon2–0ToulouseRegular Season - 31 | W |
| Apr 08 | Ligue 1 | Metz0–5LyonRegular Season - 32 | W |
| Apr 14 | Ligue 1 | Lyon3–0AmiensRegular Season - 33 | W |
| Apr 20 | Ligue 1 | Dijon2–5LyonRegular Season - 34 | W |
| Apr 28 | Ligue 1 | Lyon2–0NantesRegular Season - 35 | W |
| May 2018May 06 | Ligue 1 | Lyon3–0Estac TroyesRegular Season - 36 | W |
| May 12 | Ligue 1 | Strasbourg3–2LyonRegular Season - 37 | L |
| May 19 | Ligue 1 | Lyon3–2NiceRegular Season - 38 | W |
