| agosto de 202523 ago |  Serie A | Genoa 0–0 LecceRegular Season - 1 | E |
| 29 ago | Serie A | Lecce0–2 AC MilanRegular Season - 2 | D |
| septiembre de 202514 sept | Serie A | Atalanta 4–1LecceRegular Season - 3 | D |
| 19 sept | Serie A | Lecce1–2 CagliariRegular Season - 4 | D |
| 28 sept | Serie A | Lecce2–2 BolognaRegular Season - 5 | E |
| octubre de 202504 oct | Serie A | Parma 0–1LecceRegular Season - 6 | V |
| 18 oct | Serie A | Lecce0–0 SassuoloRegular Season - 7 | E |
| 25 oct | Serie A | Udinese 3–2LecceRegular Season - 8 | D |
| 28 oct | Serie A | Lecce0–1 NapoliRegular Season - 9 | D |
| noviembre de 202502 nov | Serie A | Fiorentina 0–1LecceRegular Season - 10 | V |
| 08 nov | Serie A | Lecce0–0 Hellas VeronaRegular Season - 11 | E |
| 23 nov | Serie A | Lazio 2–0LecceRegular Season - 12 | D |
| 30 nov | Serie A | Lecce2–1 TorinoRegular Season - 13 | V |
| diciembre de 202507 dic | Serie A | Cremonese 2–0LecceRegular Season - 14 | D |
| 12 dic | Serie A | Lecce1–0 PisaRegular Season - 15 | V |
| 27 dic | Serie A | Lecce0–3 ComoRegular Season - 17 | D |
| enero de 202603 ene | Serie A | Juventus 1–1LecceRegular Season - 18 | E |
| 06 ene | Serie A | Lecce0–2 AS RomaRegular Season - 19 | D |
| 11 ene | Serie A | Lecce1–2ParmaRegular Season - 20 | D |
| 14 ene | Serie A | Inter 1–0LecceRegular Season - 16 | D |
| 18 ene | Serie A | AC Milan1–0LecceRegular Season - 21 | D |
| 24 ene | Serie A | Lecce0–0LazioRegular Season - 22 | E |
| febrero de 202601 feb | Serie A | Torino1–0LecceRegular Season - 23 | D |
| 08 feb | Serie A | Lecce2–1UdineseRegular Season - 24 | V |
| 16 feb | Serie A | Cagliari0–2LecceRegular Season - 25 | V |
| 21 feb | Serie A | Lecce0–2InterRegular Season - 26 | D |
| 28 feb | Serie A | Como3–1LecceRegular Season - 27 | D |
| marzo de 202608 mar | Serie A | Lecce2–1CremoneseRegular Season - 28 | V |
| 14 mar | Serie A | Napoli2–1LecceRegular Season - 29 | D |
| 22 mar | Serie A | AS Roma1–0LecceRegular Season - 30 | D |
| abril de 202606 abr | Serie A | Lecce0–3AtalantaRegular Season - 31 | D |
| 12 abr | Serie A | Bologna2–0LecceRegular Season - 32 | D |
| 20 abr | Serie A | Lecce1–1FiorentinaRegular Season - 33 | E |
| 25 abr | Serie A | Hellas Verona0–0LecceRegular Season - 34 | E |
| mayo de 202601 may | Serie A | Pisa1–2LecceRegular Season - 35 | V |
| 09 may | Serie A | Lecce0–1JuventusRegular Season - 36 | D |
| 17 may | Serie A | Sassuolo2–3LecceRegular Season - 37 | V |
| 24 may | Serie A | Lecce1–0GenoaRegular Season - 38 | V |
