| août 202523 août |  Serie A | Genoa 0–0 LecceRegular Season - 1 | N |
| 29 août | Serie A | Lecce0–2 AC MilanRegular Season - 2 | D |
| septembre 202514 sept. | Serie A | Atalanta 4–1LecceRegular Season - 3 | D |
| 19 sept. | Serie A | Lecce1–2 CagliariRegular Season - 4 | D |
| 28 sept. | Serie A | Lecce2–2 BolognaRegular Season - 5 | N |
| octobre 202504 oct. | Serie A | Parma 0–1LecceRegular Season - 6 | V |
| 18 oct. | Serie A | Lecce0–0 SassuoloRegular Season - 7 | N |
| 25 oct. | Serie A | Udinese 3–2LecceRegular Season - 8 | D |
| 28 oct. | Serie A | Lecce0–1 NapoliRegular Season - 9 | D |
| novembre 202502 nov. | Serie A | Fiorentina 0–1LecceRegular Season - 10 | V |
| 08 nov. | Serie A | Lecce0–0 Hellas VeronaRegular Season - 11 | N |
| 23 nov. | Serie A | Lazio 2–0LecceRegular Season - 12 | D |
| 30 nov. | Serie A | Lecce2–1 TorinoRegular Season - 13 | V |
| décembre 202507 déc. | Serie A | Cremonese 2–0LecceRegular Season - 14 | D |
| 12 déc. | Serie A | Lecce1–0 PisaRegular Season - 15 | V |
| 27 déc. | Serie A | Lecce0–3 ComoRegular Season - 17 | D |
| janvier 202603 janv. | Serie A | Juventus 1–1LecceRegular Season - 18 | N |
| 06 janv. | Serie A | Lecce0–2 AS RomaRegular Season - 19 | D |
| 11 janv. | Serie A | Lecce1–2ParmaRegular Season - 20 | D |
| 14 janv. | Serie A | Inter 1–0LecceRegular Season - 16 | D |
| 18 janv. | Serie A | AC Milan1–0LecceRegular Season - 21 | D |
| 24 janv. | Serie A | Lecce0–0LazioRegular Season - 22 | N |
| février 202601 févr. | Serie A | Torino1–0LecceRegular Season - 23 | D |
| 08 févr. | Serie A | Lecce2–1UdineseRegular Season - 24 | V |
| 16 févr. | Serie A | Cagliari0–2LecceRegular Season - 25 | V |
| 21 févr. | Serie A | Lecce0–2InterRegular Season - 26 | D |
| 28 févr. | Serie A | Como3–1LecceRegular Season - 27 | D |
| mars 202608 mars | Serie A | Lecce2–1CremoneseRegular Season - 28 | V |
| 14 mars | Serie A | Napoli2–1LecceRegular Season - 29 | D |
| 22 mars | Serie A | AS Roma1–0LecceRegular Season - 30 | D |
| avril 202606 avr. | Serie A | Lecce0–3AtalantaRegular Season - 31 | D |
| 12 avr. | Serie A | Bologna2–0LecceRegular Season - 32 | D |
| 20 avr. | Serie A | Lecce1–1FiorentinaRegular Season - 33 | N |
| 25 avr. | Serie A | Hellas Verona0–0LecceRegular Season - 34 | N |
| mai 202601 mai | Serie A | Pisa1–2LecceRegular Season - 35 | V |
| 09 mai | Serie A | Lecce0–1JuventusRegular Season - 36 | D |
| 17 mai | Serie A | Sassuolo2–3LecceRegular Season - 37 | V |
| 24 mai | Serie A | Lecce1–0GenoaRegular Season - 38 | V |
