| août 202419 août |  Serie A | Lecce 0–4 AtalantaRegular Season - 1 | D |
| 24 août | Serie A | Inter 2–0LecceRegular Season - 2 | D |
| 31 août | Serie A | Lecce1–0 CagliariRegular Season - 3 | V |
| septembre 202415 sept. | Serie A | Torino 0–0LecceRegular Season - 4 | N |
| 21 sept. | Serie A | Lecce2–2 ParmaRegular Season - 5 | N |
| 27 sept. | Serie A | AC Milan 3–0LecceRegular Season - 6 | D |
| octobre 202405 oct. | Serie A | Udinese 1–0LecceRegular Season - 7 | D |
| 20 oct. | Serie A | Lecce0–6 FiorentinaRegular Season - 8 | D |
| 26 oct. | Serie A | Napoli 1–0LecceRegular Season - 9 | D |
| 29 oct. | Serie A | Lecce1–0 Hellas VeronaRegular Season - 10 | V |
| novembre 202402 nov. | Serie A | Bologna 1–0LecceRegular Season - 11 | D |
| 08 nov. | Serie A | Lecce1–1 EmpoliRegular Season - 12 | N |
| 25 nov. | Serie A | Venezia 0–1LecceRegular Season - 13 | V |
| décembre 202401 déc. | Serie A | Lecce1–1 JuventusRegular Season - 14 | N |
| 07 déc. | Serie A | AS Roma 4–1LecceRegular Season - 15 | D |
| 15 déc. | Serie A | Lecce2–1 MonzaRegular Season - 16 | V |
| 21 déc. | Serie A | Lecce1–2 LazioRegular Season - 17 | D |
| 30 déc. | Serie A | Como 2–0LecceRegular Season - 18 | D |
| janvier 202505 janv. | Serie A | Lecce0–0 GenoaRegular Season - 19 | N |
| 11 janv. | Serie A | Empoli1–3LecceRegular Season - 20 | V |
| 19 janv. | Serie A | Cagliari4–1LecceRegular Season - 21 | D |
| 26 janv. | Serie A | Lecce0–4InterRegular Season - 22 | D |
| 31 janv. | Serie A | Parma1–3LecceRegular Season - 23 | V |
| février 202509 févr. | Serie A | Lecce0–0BolognaRegular Season - 24 | N |
| 16 févr. | Serie A | Monza0–0LecceRegular Season - 25 | N |
| 21 févr. | Serie A | Lecce0–1UdineseRegular Season - 26 | D |
| 28 févr. | Serie A | Fiorentina1–0LecceRegular Season - 27 | D |
| mars 202508 mars | Serie A | Lecce2–3AC MilanRegular Season - 28 | D |
| 14 mars | Serie A | Genoa2–1LecceRegular Season - 29 | D |
| 29 mars | Serie A | Lecce0–1AS RomaRegular Season - 30 | D |
| avril 202506 avr. | Serie A | Lecce1–1VeneziaRegular Season - 31 | N |
| 12 avr. | Serie A | Juventus2–1LecceRegular Season - 32 | D |
| 19 avr. | Serie A | Lecce0–3ComoRegular Season - 33 | D |
| 27 avr. | Serie A | Atalanta1–1LecceRegular Season - 34 | N |
| mai 202503 mai | Serie A | Lecce0–1NapoliRegular Season - 35 | D |
| 11 mai | Serie A | Hellas Verona1–1LecceRegular Season - 36 | N |
| 18 mai | Serie A | Lecce1–0TorinoRegular Season - 37 | V |
| 25 mai | Serie A | Lazio0–1LecceRegular Season - 38 | V |
