| août 202623 août |  Serie A | Venezia 18:30 LecceRegular Season - 1 | — |
| 31 août | Serie A | Lecce18:30 AS RomaRegular Season - 2 | — |
| septembre 202607 sept. | Serie A | Cagliari 18:00LecceRegular Season - 3 | — |
| 13 sept. | Serie A | Lecce15:00 MonzaRegular Season - 4 | — |
| 20 sept. | Serie A | AC Milan 20:45LecceRegular Season - 5 | — |
| octobre 202611 oct. | Serie A | Lecce18:30 BolognaRegular Season - 6 | — |
| 18 oct. | Serie A | Udinese 18:30LecceRegular Season - 7 | — |
| 25 oct. | Serie A | Lecce18:30 JuventusRegular Season - 8 | — |
| 28 oct. | Serie A | Frosinone 18:30LecceRegular Season - 9 | — |
| novembre 202601 nov. | Serie A | Lecce18:30 GenoaRegular Season - 10 | — |
| 08 nov. | Serie A | Torino 18:30LecceRegular Season - 11 | — |
| 22 nov. | Serie A | Lazio 18:30LecceRegular Season - 12 | — |
| 29 nov. | Serie A | Lecce18:30 AtalantaRegular Season - 13 | — |
| décembre 202606 déc. | Serie A | Napoli 18:30LecceRegular Season - 14 | — |
| 13 déc. | Serie A | Lecce18:30 SassuoloRegular Season - 15 | — |
| 20 déc. | Serie A | Lecce18:30 InterRegular Season - 16 | — |
| janvier 202703 janv. | Serie A | Como 18:30LecceRegular Season - 17 | — |
| 06 janv. | Serie A | Lecce18:30 ParmaRegular Season - 18 | — |
| 10 janv. | Serie A | Fiorentina 18:30LecceRegular Season - 19 | — |
| 17 janv. | Serie A | Lecce18:30UdineseRegular Season - 20 | — |
| 24 janv. | Serie A | Lecce18:30TorinoRegular Season - 21 | — |
| 31 janv. | Serie A | Genoa18:30LecceRegular Season - 22 | — |
| février 202707 févr. | Serie A | Lecce18:30NapoliRegular Season - 23 | — |
| 14 févr. | Serie A | Monza18:30LecceRegular Season - 24 | — |
| 21 févr. | Serie A | Lecce18:30FrosinoneRegular Season - 25 | — |
| 28 févr. | Serie A | Bologna18:30LecceRegular Season - 26 | — |
| mars 202707 mars | Serie A | Lecce18:30ComoRegular Season - 27 | — |
| 14 mars | Serie A | Parma18:30LecceRegular Season - 28 | — |
| 21 mars | Serie A | AS Roma18:30LecceRegular Season - 29 | — |
| avril 202704 avr. | Serie A | Lecce18:30LazioRegular Season - 30 | — |
| 11 avr. | Serie A | Juventus18:30LecceRegular Season - 31 | — |
| 18 avr. | Serie A | Sassuolo18:30LecceRegular Season - 32 | — |
| 25 avr. | Serie A | Lecce18:30AC MilanRegular Season - 33 | — |
| mai 202702 mai | Serie A | Lecce18:30CagliariRegular Season - 34 | — |
| 09 mai | Serie A | Inter18:30LecceRegular Season - 35 | — |
| 16 mai | Serie A | Lecce18:30FiorentinaRegular Season - 36 | — |
| 23 mai | Serie A | Atalanta18:30LecceRegular Season - 37 | — |
| 30 mai | Serie A | Lecce18:30VeneziaRegular Season - 38 | — |
