| août 202320 août |  Serie A | Lecce 2–1 LazioRegular Season - 1 | V |
| 27 août | Serie A | Fiorentina 2–2LecceRegular Season - 2 | N |
| septembre 202303 sept. | Serie A | Lecce2–0 SalernitanaRegular Season - 3 | V |
| 17 sept. | Serie A | Monza 1–1LecceRegular Season - 4 | N |
| 22 sept. | Serie A | Lecce1–0 GenoaRegular Season - 5 | V |
| 26 sept. | Serie A | Juventus 1–0LecceRegular Season - 6 | D |
| 30 sept. | Serie A | Lecce0–4 NapoliRegular Season - 7 | D |
| octobre 202306 oct. | Serie A | Lecce1–1 SassuoloRegular Season - 8 | N |
| 23 oct. | Serie A | Udinese 1–1LecceRegular Season - 9 | N |
| 28 oct. | Serie A | Lecce0–1 TorinoRegular Season - 10 | D |
| novembre 202305 nov. | Serie A | AS Roma 2–1LecceRegular Season - 11 | D |
| 11 nov. | Serie A | Lecce2–2 AC MilanRegular Season - 12 | N |
| 27 nov. | Serie A | Hellas Verona 2–2LecceRegular Season - 13 | N |
| décembre 202303 déc. | Serie A | Lecce1–1 BolognaRegular Season - 14 | N |
| 11 déc. | Serie A | Empoli 1–1LecceRegular Season - 15 | N |
| 16 déc. | Serie A | Lecce2–1 FrosinoneRegular Season - 16 | V |
| 23 déc. | Serie A | Inter 2–0LecceRegular Season - 17 | D |
| 30 déc. | Serie A | Atalanta 1–0LecceRegular Season - 18 | D |
| janvier 202406 janv. | Serie A | Lecce1–1 CagliariRegular Season - 19 | N |
| 14 janv. | Serie A | Lazio1–0LecceRegular Season - 20 | D |
| 21 janv. | Serie A | Lecce0–3JuventusRegular Season - 21 | D |
| 28 janv. | Serie A | Genoa2–1LecceRegular Season - 22 | D |
| février 202402 févr. | Serie A | Lecce3–2FiorentinaRegular Season - 23 | V |
| 11 févr. | Serie A | Bologna4–0LecceRegular Season - 24 | D |
| 16 févr. | Serie A | Torino2–0LecceRegular Season - 25 | D |
| 25 févr. | Serie A | Lecce0–4InterRegular Season - 26 | D |
| mars 202403 mars | Serie A | Frosinone1–1LecceRegular Season - 27 | N |
| 10 mars | Serie A | Lecce0–1Hellas VeronaRegular Season - 28 | D |
| 16 mars | Serie A | Salernitana0–1LecceRegular Season - 29 | V |
| avril 202401 avr. | Serie A | Lecce0–0AS RomaRegular Season - 30 | N |
| 06 avr. | Serie A | AC Milan3–0LecceRegular Season - 31 | D |
| 13 avr. | Serie A | Lecce1–0EmpoliRegular Season - 32 | V |
| 21 avr. | Serie A | Sassuolo0–3LecceRegular Season - 33 | V |
| 27 avr. | Serie A | Lecce1–1MonzaRegular Season - 34 | N |
| mai 202405 mai | Serie A | Cagliari1–1LecceRegular Season - 35 | N |
| 13 mai | Serie A | Lecce0–2UdineseRegular Season - 36 | D |
| 18 mai | Serie A | Lecce0–2AtalantaRegular Season - 37 | D |
| 26 mai | Serie A | Napoli0–0LecceRegular Season - 38 | N |
