| August 2023Aug 20 |  Serie A | Lecce 2–1 LazioRegular Season - 1 | W |
| Aug 27 | Serie A | Fiorentina 2–2LecceRegular Season - 2 | D |
| September 2023Sep 03 | Serie A | Lecce2–0 SalernitanaRegular Season - 3 | W |
| Sep 17 | Serie A | Monza 1–1LecceRegular Season - 4 | D |
| Sep 22 | Serie A | Lecce1–0 GenoaRegular Season - 5 | W |
| Sep 26 | Serie A | Juventus 1–0LecceRegular Season - 6 | L |
| Sep 30 | Serie A | Lecce0–4 NapoliRegular Season - 7 | L |
| October 2023Oct 06 | Serie A | Lecce1–1 SassuoloRegular Season - 8 | D |
| Oct 23 | Serie A | Udinese 1–1LecceRegular Season - 9 | D |
| Oct 28 | Serie A | Lecce0–1 TorinoRegular Season - 10 | L |
| November 2023Nov 05 | Serie A | AS Roma 2–1LecceRegular Season - 11 | L |
| Nov 11 | Serie A | Lecce2–2 AC MilanRegular Season - 12 | D |
| Nov 27 | Serie A | Hellas Verona 2–2LecceRegular Season - 13 | D |
| December 2023Dec 03 | Serie A | Lecce1–1 BolognaRegular Season - 14 | D |
| Dec 11 | Serie A | Empoli 1–1LecceRegular Season - 15 | D |
| Dec 16 | Serie A | Lecce2–1 FrosinoneRegular Season - 16 | W |
| Dec 23 | Serie A | Inter 2–0LecceRegular Season - 17 | L |
| Dec 30 | Serie A | Atalanta 1–0LecceRegular Season - 18 | L |
| January 2024Jan 06 | Serie A | Lecce1–1 CagliariRegular Season - 19 | D |
| Jan 14 | Serie A | Lazio1–0LecceRegular Season - 20 | L |
| Jan 21 | Serie A | Lecce0–3JuventusRegular Season - 21 | L |
| Jan 28 | Serie A | Genoa2–1LecceRegular Season - 22 | L |
| February 2024Feb 02 | Serie A | Lecce3–2FiorentinaRegular Season - 23 | W |
| Feb 11 | Serie A | Bologna4–0LecceRegular Season - 24 | L |
| Feb 16 | Serie A | Torino2–0LecceRegular Season - 25 | L |
| Feb 25 | Serie A | Lecce0–4InterRegular Season - 26 | L |
| March 2024Mar 03 | Serie A | Frosinone1–1LecceRegular Season - 27 | D |
| Mar 10 | Serie A | Lecce0–1Hellas VeronaRegular Season - 28 | L |
| Mar 16 | Serie A | Salernitana0–1LecceRegular Season - 29 | W |
| April 2024Apr 01 | Serie A | Lecce0–0AS RomaRegular Season - 30 | D |
| Apr 06 | Serie A | AC Milan3–0LecceRegular Season - 31 | L |
| Apr 13 | Serie A | Lecce1–0EmpoliRegular Season - 32 | W |
| Apr 21 | Serie A | Sassuolo0–3LecceRegular Season - 33 | W |
| Apr 27 | Serie A | Lecce1–1MonzaRegular Season - 34 | D |
| May 2024May 05 | Serie A | Cagliari1–1LecceRegular Season - 35 | D |
| May 13 | Serie A | Lecce0–2UdineseRegular Season - 36 | L |
| May 18 | Serie A | Lecce0–2AtalantaRegular Season - 37 | L |
| May 26 | Serie A | Napoli0–0LecceRegular Season - 38 | D |
